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Metabolic Activation and Binding of Mitotane in Adrenal Cortex Homogenates

Journal of pharmaceutical sciences, 1995-02, Vol.84 (2), p.134-138

1995

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Adrenal proteins bound by a reactive intermediate of mitotane

Cancer chemotherapy and pharmacology, 1997, Vol.39 (6), p.537-540

1997

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Base-pair mutations caused by six aliphatic epoxides in salmonella typhimurium TA100, TA104, TA4001, and TA4006

Environmental and molecular mutagenesis, 1993, Vol.21 (3), p.253-257

1993

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Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma

Cancer chemotherapy and pharmacology, 1993, Vol.31 (6), p.459-466

1993

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Molecular analysis of hypoxanthine phosphoribosyl transferase mutants induced by glycidyl 1-naphthyl ether in mouse spleen cells in vivo

Environmental and molecular mutagenesis, 1993, Vol.22 (2), p.71-77

1993

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Gas chromatographic-electron capture determination of 2,4′-dichlorodiphenylacetic acid from in-vitro adrenal transformations of mitotane and its analogs

Journal of pharmaceutical and biomedical analysis, 1996-05, Vol.14 (7), p.861-866

1996

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Genotoxicity of chryseno[4,5-bcd]thiophene and its sulfone derivative

Environmental and molecular mutagenesis, 1992, Vol.19 (3), p.259-264

1992

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Comparison of the isolation of adducts of 2'-deoxycytidine and 2'-deoxyguanosine with phenylglycidyl ether by high-performance liquid chromatography on a reversed-phase column and a polystyrene-divinylbenzene column

Journal of chromatography, 1991-03, Vol.541 (1-2), p.317-331

1991

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Mitotane (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane) metabolism in perfusion studies with dog adrenal glands

Drug metabolism and disposition, 1987-03, Vol.15 (2), p.267

1987

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Bovine adrenal cortex transformations of mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; o, p′-DDD] and its p, p′- and m, p′-isomers

Biochemical pharmacology, 1995-05, Vol.49 (10), p.1483-1489

1995

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Adduct formation identification between phenyl glycidyl ether and 2′-deoxyadenosine and thymidine by chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy

Journal of Chromatography A, 1990, Vol.504 (1), p.113-128

1990

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Mutagenicity in salmonella and sister chromatid exchange in mice for 1,4-, 1,3-, 2,4-, and 3,4-dimethylphenanthrenes

Environmental and molecular mutagenesis, 1991, Vol.17 (2), p.93-97

1991

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Detoxication of aliphatic epoxides by diol formation and glutathione conjugation

Chemico-biological interactions, 1987, Vol.63 (1), p.75-90

1987

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High-performance thin-layer chromatography assay for epoxide hydrolase activity and the determination of phenoxypropane-1,2-diols

Journal of Chromatography A, 1985-01, Vol.318 (2), p.343-349

1985

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Enantioselective detoxication of optical isomers of glycidyl ethers

Chirality (New York, N.Y.), 1993, Vol.5 (7), p.501-504

1993

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Mutagenicity in Salmonella and sister chromatid exchange in mice for the bay-region syn-and anti-diol epoxides of 1, 4-dimethylphenanthrene

Carcinogenesis (New York), 1989-06, Vol.10 (6), p.1123-1126

1989

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Reactivity of propylene oxides towards deoxycytidine and identification of reaction products

Chemico-biological interactions, 1984-01, Vol.50 (2), p.219-231

1984

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Mitotane ( o, p′-DDD) emulsion and tablet analysis by high-performance liquid chromatography

Journal of Chromatography A, 1985-01, Vol.319 (3), p.467-470

1985

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A sensitive fluorimetric procedure for the determination of aliphatic epoxides under physiological conditions

Analytical biochemistry, 1981-07, Vol.115 (1), p.151-157

1981

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Direct Chloride Measurement of [4-36Cl]Chlorobiphenyl and [4,4′-36Cl]Dichlorobiphenyl Dechlorination in the Rat

Journal of pharmaceutical sciences, 1984-08, Vol.73 (8), p.1171-1172

1984

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In Vitro Dehalogenation of para-Substituted Aromatic Halides in Rat Liver Preparations

Journal of pharmaceutical sciences, 1984-08, Vol.73 (8), p.1101-1104

1984

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Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives

Toxicology letters, 1985-01, Vol.25 (3), p.265-271

1985

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Structure-mutagenicity relationships of benzidine analogues

Environmental and molecular mutagenesis, 1987, Vol.10 (3), p.263-274

1987

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Characterization and quantitation of 3-alkylthymidines from reactions of mutagenic propylene oxides with thymidine

Chemico-biological interactions, 1984-01, Vol.52 (2), p.243-253

1984

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Comparison of the alkylation of nicotinamide and 4-(p-nitrobenzyl)pyridine for the determination of aliphatic epoxides

Analytical chemistry (Washington), 1982-02, Vol.54 (2), p.213-216

1982

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Metabolic Activation and Binding of Mitotane in Adrenal Cortex Homogenates

Adrenal proteins bound by a reactive intermediate of mitotane

Base-pair mutations caused by six aliphatic epoxides in salmonella typhimurium TA100, TA104, TA4001, and TA4006

Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma

Molecular analysis of hypoxanthine phosphoribosyl transferase mutants induced by glycidyl 1-naphthyl ether in mouse spleen cells in vivo

Gas chromatographic-electron capture determination of 2,4′-dichlorodiphenylacetic acid from in-vitro adrenal transformations of mitotane and its analogs

Genotoxicity of chryseno[4,5-bcd]thiophene and its sulfone derivative

Comparison of the isolation of adducts of 2'-deoxycytidine and 2'-deoxyguanosine with phenylglycidyl ether by high-performance liquid chromatography on a reversed-phase column and a polystyrene-divinylbenzene column

Mitotane (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane) metabolism in perfusion studies with dog adrenal glands

Bovine adrenal cortex transformations of mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; o, p′-DDD] and its p, p′- and m, p′-isomers

Adduct formation identification between phenyl glycidyl ether and 2′-deoxyadenosine and thymidine by chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy

Mutagenicity in salmonella and sister chromatid exchange in mice for 1,4-, 1,3-, 2,4-, and 3,4-dimethylphenanthrenes

Detoxication of aliphatic epoxides by diol formation and glutathione conjugation

High-performance thin-layer chromatography assay for epoxide hydrolase activity and the determination of phenoxypropane-1,2-diols

Enantioselective detoxication of optical isomers of glycidyl ethers

Mutagenicity in Salmonella and sister chromatid exchange in mice for the bay-region syn-and anti-diol epoxides of 1, 4-dimethylphenanthrene

Reactivity of propylene oxides towards deoxycytidine and identification of reaction products

Mitotane ( o, p′-DDD) emulsion and tablet analysis by high-performance liquid chromatography

A sensitive fluorimetric procedure for the determination of aliphatic epoxides under physiological conditions

Direct Chloride Measurement of [4-36Cl]Chlorobiphenyl and [4,4′-36Cl]Dichlorobiphenyl Dechlorination in the Rat

In Vitro Dehalogenation of para-Substituted Aromatic Halides in Rat Liver Preparations

Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives

Structure-mutagenicity relationships of benzidine analogues

Characterization and quantitation of 3-alkylthymidines from reactions of mutagenic propylene oxides with thymidine

Comparison of the alkylation of nicotinamide and 4-(p-nitrobenzyl)pyridine for the determination of aliphatic epoxides

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