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A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

PLoS computational biology, 2018-01, Vol.14 (1), p.e1005907-e1005907

2018

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Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter

The Journal of biological chemistry, 2018-03, Vol.293 (10), p.3510-3523

2018

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5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release

Scientific reports, 2024-03, Vol.14 (1), p.6541-6541, Article 6541

2024

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A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state

Nature communications, 2016-05, Vol.7 (1), p.11673-11673, Article 11673

2016

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Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release

PLoS computational biology, 2011-10, Vol.7 (10), p.e1002246

2011

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Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter

The Journal of biological chemistry, 2010-03, Vol.285 (11), p.8363-8374

2010

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Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter

Bioorganic & medicinal chemistry, 2016-06, Vol.24 (12), p.2725-2738

2016

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A Dualistic Conformational Response to Substrate Binding in the Human Serotonin Transporter Reveals a High Affinity State for Serotonin

The Journal of biological chemistry, 2015-03, Vol.290 (12), p.7747-7755

2015

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Structural insights into the inhibition of glycine reuptake

Nature (London), 2021-03, Vol.591 (7851), p.677-681

2021

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A review of possible biomarkers for opioid tolerance

Forensic science international, 2024-10, Vol.363, p.112187, Article 112187

2024

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Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies

Neuropharmacology, 2019-12, Vol.161, p.107548-107548, Article 107548

2019

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Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters

Bioorganic & medicinal chemistry, 2007-06, Vol.15 (12), p.4159-4174

2007

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Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT

Proceedings of the National Academy of Sciences - PNAS, 2018-09, Vol.115 (38), p.E8854-E8862

2018

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Nuclear Medicine Preclinical Research: The Role of Cell Cultures

Seminars in nuclear medicine, 2023-09, Vol.53 (5), p.558-569

2023

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Serotonin Signaling through Lipid Membranes

ACS chemical neuroscience, 2024-04, Vol.15 (7), p.1298-1320

2024

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A Photoswitchable Inhibitor of the Human Serotonin Transporter

ACS chemical neuroscience, 2020-05, Vol.11 (9), p.1231-1237

2020

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The Two Enantiomers of Citalopram Bind to the Human Serotonin Transporter in Reversed Orientations

Journal of the American Chemical Society, 2010-02, Vol.132 (4), p.1311-1322

2010

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Comparative Modeling of the Human Monoamine Transporters: Similarities in Substrate Binding

ACS chemical neuroscience, 2013-02, Vol.4 (2), p.295-309

2013

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Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

The Journal of biological chemistry, 2015-06, Vol.290 (23), p.14582-14594

2015

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Binding of Serotonin to the Human Serotonin Transporter. Molecular Modeling and Experimental Validation

Journal of the American Chemical Society, 2008-03, Vol.130 (12), p.3853-3865

2008

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Synthesis of 3,7-Disubstituted Imipramines by Palladium-Catalysed Amination/Cyclisation and Evaluation of Their Inhibition of Monoamine Transporters

Chemistry : a European journal, 2011-09, Vol.17 (38), p.10618-10627

2011

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Binding of mazindol and analogs to the human serotonin and dopamine transporters

Molecular pharmacology, 2014-02, Vol.85 (2), p.208-217

2014

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Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt’s lymphoma

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1220-1224

2013

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Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site

Journal of neurochemistry, 2008-06, Vol.105 (5), p.1794-1805

2008

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Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and [Na.sup.+] ion release

PLoS computational biology, 2011-10, Vol.7 (10)

2011

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A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter

5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release

A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state

Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release

Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter

Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter

A Dualistic Conformational Response to Substrate Binding in the Human Serotonin Transporter Reveals a High Affinity State for Serotonin

Structural insights into the inhibition of glycine reuptake

A review of possible biomarkers for opioid tolerance

Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies

Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT

Nuclear Medicine Preclinical Research: The Role of Cell Cultures

Serotonin Signaling through Lipid Membranes

A Photoswitchable Inhibitor of the Human Serotonin Transporter

The Two Enantiomers of Citalopram Bind to the Human Serotonin Transporter in Reversed Orientations

Comparative Modeling of the Human Monoamine Transporters: Similarities in Substrate Binding

Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

Binding of Serotonin to the Human Serotonin Transporter. Molecular Modeling and Experimental Validation

Synthesis of 3,7-Disubstituted Imipramines by Palladium-Catalysed Amination/Cyclisation and Evaluation of Their Inhibition of Monoamine Transporters

Binding of mazindol and analogs to the human serotonin and dopamine transporters

Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt’s lymphoma

Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site

Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and [Na.sup.+] ion release

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