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Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.16101-16106

2012

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Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

Molecular neurodegeneration, 2023-11, Vol.18 (1), p.79-79, Article 79

2023

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TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer

Oncogene, 2023-03, Vol.42 (14), p.1132-1143

2023

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Targeting Cell Surface Alpha(v)beta(3) Integrin Increases Therapeutic Efficacies of a Legumain Protease-Activated Auristatin Prodrug

Molecular pharmaceutics, 2012-01, Vol.9 (1), p.168-175

2012

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Chemically Programmed Bispecific Antibodies in Diabody Format

The Journal of biological chemistry, 2016-09, Vol.291 (37), p.19661-19673

2016

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Tissue Factor-Activated Coagulation Cascade in the Tumor Microenvironment Is Critical for Tumor Progression and an Effective Target for Therapy

Cancer research (Chicago, Ill.), 2011-10, Vol.71 (20), p.6492-6502

2011

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Ahnak in the prefrontal cortex mediates behavioral correlates of stress resilience and rapid antidepressant action in mice

Frontiers in molecular neuroscience, 2024-05, Vol.17, p.1350716

2024

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Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

Molecular neurodegeneration, 2024-06, Vol.19 (1), p.51-19, Article 51

2024

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The Legumain Protease-Activated Auristatin Prodrugs Suppress Tumor Growth and Metastasis without Toxicity

ChemMedChem, 2011-01, Vol.6 (1), p.54-59

2011

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SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth

Chemical communications (Cambridge, England), 2017, Vol.53 (30), p.4234-4237

2017

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Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells

Journal for immunotherapy of cancer, 2020-08, Vol.8 (2), p.e000494

2020

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Instant immunity through chemically programmable vaccination and covalent self-assembly

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (11), p.4378-4383

2009

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Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression

Biological psychiatry (1969), 2020-09, Vol.88 (5), p.405-414

2020

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Genetic Incorporation of Multiple Unnatural Amino Acids into Proteins in Mammalian Cells

Angewandte Chemie (International ed.), 2013-12, Vol.52 (52), p.14080-14083

International ed. in English, 2013

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Semiquinone and Cluster N6 Signals in His-tagged Proton-translocating NADH:Ubiquinone Oxidoreductase (Complex I) from Escherichia coli

The Journal of biological chemistry, 2013-05, Vol.288 (20), p.14310-14319

2013

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Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience

Nature neuroscience, 2023-05, Vol.26 (5), p.737

2023

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Mathematical modeling and simulation of nonlinear spacecraft rendezvous and formation flying problems via averaging method

Communications in nonlinear science & numerical simulation, 2021-04, Vol.95, p.105668, Article 105668

2021

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Activation of respiratory Complex I from Escherichia coli studied by fluorescent probes

Heliyon, 2017-01, Vol.3 (1), p.e00224-e00224, Article e00224

2017

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An efficient chemical approach to bispecific antibodies and antibodies of high valency

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (14), p.3716-3720

2009

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Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development

Cancer letters, 2021-09, Vol.515, p.1-13

2021

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Development of Gleevec Analogues for Reducing Production of β‑Amyloid Peptides through Shifting β‑Cleavage of Amyloid Precursor Proteins

Journal of medicinal chemistry, 2019-03, Vol.62 (6), p.3122-3134

2019

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MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

Oncogene, 2021-10, Vol.40 (43), p.6153-6165

2021

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Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (6), p.1389-1394

2017

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AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

Science translational medicine, 2021-12, Vol.13 (622), p.eabe3947

2021

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Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels

ACS chemical biology, 2024-01, Vol.19 (1), p.37-47

2024

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Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer

Targeting Cell Surface Alpha(v)beta(3) Integrin Increases Therapeutic Efficacies of a Legumain Protease-Activated Auristatin Prodrug

Chemically Programmed Bispecific Antibodies in Diabody Format

Tissue Factor-Activated Coagulation Cascade in the Tumor Microenvironment Is Critical for Tumor Progression and an Effective Target for Therapy

Ahnak in the prefrontal cortex mediates behavioral correlates of stress resilience and rapid antidepressant action in mice

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

The Legumain Protease-Activated Auristatin Prodrugs Suppress Tumor Growth and Metastasis without Toxicity

SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth

Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells

Instant immunity through chemically programmable vaccination and covalent self-assembly

Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression

Genetic Incorporation of Multiple Unnatural Amino Acids into Proteins in Mammalian Cells

Semiquinone and Cluster N6 Signals in His-tagged Proton-translocating NADH:Ubiquinone Oxidoreductase (Complex I) from Escherichia coli

Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience

Mathematical modeling and simulation of nonlinear spacecraft rendezvous and formation flying problems via averaging method

Activation of respiratory Complex I from Escherichia coli studied by fluorescent probes

An efficient chemical approach to bispecific antibodies and antibodies of high valency

Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development

Development of Gleevec Analogues for Reducing Production of β‑Amyloid Peptides through Shifting β‑Cleavage of Amyloid Precursor Proteins

MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage

AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels

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