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Targeting the ATF4 pathway in cancer therapy

Expert opinion on therapeutic targets, 2012-12, Vol.16 (12), p.1189-1202

2012

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Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

Journal of the American Chemical Society, 2014-07, Vol.136 (26), p.9308-9319

2014

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Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

Biochemical journal, 2013-01, Vol.449 (2), p.389-400

2013

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Angewandte Chemie International Edition, 2015-05, Vol.54 (21), p.6217-6221

International ed. in English, 2015

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Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

Cell cycle (Georgetown, Tex.), 2009-12, Vol.8 (23), p.3838-3847

2009

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Therapeutic targeting of the hypoxic tumour microenvironment

Nature reviews. Clinical oncology, 2021-12, Vol.18 (12), p.751-772

2021

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Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer

BMC cancer, 2020-05, Vol.20 (1), p.470-470, Article 470

2020

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N-Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation

Thrombosis and haemostasis, 2020-04, Vol.120 (4), p.671-686

2020

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Clinical relevance and therapeutic predictive ability of hypoxia biomarkers in head and neck cancer tumour models

Molecular oncology, 2024-08, Vol.18 (8), p.1885-1903

2024

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Bystander or no bystander for gene directed enzyme prodrug therapy

Molecules, 2009-11, Vol.14 (11), p.4517-4545

2009

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In vitro breast cancer models for studying mechanisms of resistance to endocrine therapy

Exploration of targeted anti-tumor therapy, 2022, Vol.3 (3), p.297-320

2022

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Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations

Frontiers in oncology, 2018-10, Vol.8, p.425-425

2018

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Megakaryocyte maturation involves activation of the adaptive unfolded protein response

Genes to cells : devoted to molecular & cellular mechanisms, 2024-10, Vol.29 (10), p.889-901

2024

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Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit

Cancer gene therapy, 2022-07, Vol.29 (7), p.1021-1032

2022

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Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer

Cancers, 2020-12, Vol.12 (12), p.3743

2020

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Hypoxia‐Activated Prodrugs of PERK Inhibitors

Chemistry, an Asian journal, 2019-04, Vol.14 (8), p.1238-1248

2019

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Microenvironmental induced essentiality of autophagy

Clinical cancer research, 2013-06, Vol.19 (11), p.2791-2793

2013

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Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis

Oncogene, 2015-09, Vol.34 (36), p.4713-4722

2015

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Angewandte Chemie, 2015-05, Vol.127 (21), p.6315-6319

2015

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Abstract 3561: HIF-1α stabilisation in triple receptor negative breast cancer is sensitive to glutaminase inhibition

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.3561-3561

2020

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Abstract 4333: Identification of glucose-6-phosphate dehydrogenase dependency in IDH1 mutant glioma cells using functional genomics

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.4333-4333

2024

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Abstract 1753: SHOC2 is a genetic dependency in NRAS -mutant melanoma

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1753-1753

2024

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Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

Journal of enzyme inhibition and medicinal chemistry, 2015-01, Vol.30 (5), p.689-721

2015

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Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411 NTR leading to therapeutic benefit

Cancer gene therapy, 2022-07, Vol.29 (7), p.1021

2022

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Abstract 3947: Hypoxic regulation of RIO kinase 3 promotes cell migration and invasion

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.3947-3947

2012

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Targeting the ATF4 pathway in cancer therapy

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

Therapeutic targeting of the hypoxic tumour microenvironment

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer

N-Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation

Clinical relevance and therapeutic predictive ability of hypoxia biomarkers in head and neck cancer tumour models

Bystander or no bystander for gene directed enzyme prodrug therapy

In vitro breast cancer models for studying mechanisms of resistance to endocrine therapy

Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations

Megakaryocyte maturation involves activation of the adaptive unfolded protein response

Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit

Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer

Hypoxia‐Activated Prodrugs of PERK Inhibitors

Microenvironmental induced essentiality of autophagy

Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Abstract 3561: HIF-1α stabilisation in triple receptor negative breast cancer is sensitive to glutaminase inhibition

Abstract 4333: Identification of glucose-6-phosphate dehydrogenase dependency in IDH1 mutant glioma cells using functional genomics

Abstract 1753: SHOC2 is a genetic dependency in NRAS -mutant melanoma

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411 NTR leading to therapeutic benefit

Abstract 3947: Hypoxic regulation of RIO kinase 3 promotes cell migration and invasion

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