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Dissecting transcriptional amplification by MYC

eLife, 2020-07, Vol.9

2020

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Minireview: Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges

Molecular endocrinology (Baltimore, Md.), 2014-02, Vol.28 (2), p.173-182

2014

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Variable steroid receptor responses: Intrinsically disordered AF1 is the key

Molecular and cellular endocrinology, 2013-08, Vol.376 (1-2), p.81-84

2013

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Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

Molecular and Cellular Biology, 2008-03, Vol.28 (6), p.1915-1923

2008

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What goes on behind closed doors: physiological versus pharmacological steroid hormone actions

BioEssays, 2008-08, Vol.30 (8), p.744-756

Simons, S. Stoney Jr

2008

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An Approach to Greater Specificity for Glucocorticoids

Frontiers in endocrinology (Lausanne), 2018-03, Vol.9, p.76-76

2018

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The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events

Critical reviews in toxicology, 2014-08, Vol.44 (S3), p.17-43

2014

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theoretical framework for gene induction and experimental comparisons

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (15), p.7107-7112

2010

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Glucocorticoid receptor cofactors as therapeutic targets

Current opinion in pharmacology, 2010-12, Vol.10 (6), p.613-619

Simons Jr, S Stoney

2010

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Binding of the N-terminal Region of Coactivator TIF2 to the Intrinsically Disordered AF1 Domain of the Glucocorticoid Receptor Is Accompanied by Conformational Reorganizations

The Journal of biological chemistry, 2012-12, Vol.287 (53), p.44546-44560

2012

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Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction

Molecular and cellular endocrinology, 2009-02, Vol.299 (2), p.219-231

2009

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Kinetically-defined component actions in gene repression

PLoS computational biology, 2015-03, Vol.11 (3), p.e1004122-e1004122

2015

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Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction

Molecular and cellular endocrinology, 2012-05, Vol.355 (1), p.121-134

2012

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The road less traveled: New views of steroid receptor action from the path of dose–response curves

Molecular and cellular endocrinology, 2012-01, Vol.348 (2), p.373-382

2012

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Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification

PloS one, 2012-01, Vol.7 (1), p.e30225

2012

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Research Resource: Modulators of Glucocorticoid Receptor Activity Identified by a New High-Throughput Screening Assay

Molecular endocrinology (Baltimore, Md.), 2014-07, Vol.28 (7), p.1194-1206

2014

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A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-regulated Gene Induction Properties

The Journal of biological chemistry, 2013-11, Vol.288 (47), p.34055-34072

2013

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PA1 Protein, a New Competitive Decelerator Acting at More than One Step to Impede Glucocorticoid Receptor-mediated Transactivation

The Journal of biological chemistry, 2013-01, Vol.288 (1), p.42-58

2013

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STAMP, a Novel Predicted Factor Assisting TIF2 Actions in Glucocorticoid Receptor-Mediated Induction and Repression

Molecular and Cellular Biology, 2007-02, Vol.27 (4), p.1467-1485

2007

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Ligand Binding Domain Mutations of the Glucocorticoid Receptor Selectively Modify the Effects with, but Not Binding of, Cofactors

Biochemistry (Easton), 2011-01, Vol.50 (3), p.356-366

2011

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Amino-Terminal Domain of TIF2 Is Involved in Competing for Corepressor Binding to Glucocorticoid and Progesterone Receptors

Biochemistry (Easton), 2007-07, Vol.46 (27), p.8036-8049

2007

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A Kinase-Independent Activity of Cdk9 Modulates Glucocorticoid Receptor-Mediated Gene Induction

Biochemistry (Easton), 2014-03, Vol.53 (11), p.1753-1767

2014

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Differential modulation of glucocorticoid and progesterone receptor transactivation

Molecular and cellular endocrinology, 2008-02, Vol.283 (1), p.114-126

2008

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Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction

The Journal of biological chemistry, 2016-01, Vol.291 (1), p.342-354

2016

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Modulation of transcription parameters in glucocorticoid receptor-mediated repression

Molecular and cellular endocrinology, 2008-11, Vol.295 (1), p.59-69

2008

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Dissecting transcriptional amplification by MYC

Minireview: Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges

Variable steroid receptor responses: Intrinsically disordered AF1 is the key

Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

What goes on behind closed doors: physiological versus pharmacological steroid hormone actions

An Approach to Greater Specificity for Glucocorticoids

The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events

theoretical framework for gene induction and experimental comparisons

Glucocorticoid receptor cofactors as therapeutic targets

Binding of the N-terminal Region of Coactivator TIF2 to the Intrinsically Disordered AF1 Domain of the Glucocorticoid Receptor Is Accompanied by Conformational Reorganizations

Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction

Kinetically-defined component actions in gene repression

Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction

The road less traveled: New views of steroid receptor action from the path of dose–response curves

Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification

Research Resource: Modulators of Glucocorticoid Receptor Activity Identified by a New High-Throughput Screening Assay

A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-regulated Gene Induction Properties

PA1 Protein, a New Competitive Decelerator Acting at More than One Step to Impede Glucocorticoid Receptor-mediated Transactivation

STAMP, a Novel Predicted Factor Assisting TIF2 Actions in Glucocorticoid Receptor-Mediated Induction and Repression

Ligand Binding Domain Mutations of the Glucocorticoid Receptor Selectively Modify the Effects with, but Not Binding of, Cofactors

Amino-Terminal Domain of TIF2 Is Involved in Competing for Corepressor Binding to Glucocorticoid and Progesterone Receptors

A Kinase-Independent Activity of Cdk9 Modulates Glucocorticoid Receptor-Mediated Gene Induction

Differential modulation of glucocorticoid and progesterone receptor transactivation

Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction

Modulation of transcription parameters in glucocorticoid receptor-mediated repression

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