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Role of LCAT in Atherosclerosis

Journal of Atherosclerosis and Thrombosis, 2016/02/01, Vol.23(2), pp.119-127

2016

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Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease

Atherosclerosis, 2012-06, Vol.222 (2), p.299-306

2012

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HDL and atherosclerosis: Insights from inherited HDL disorders

Biochimica et biophysica acta, 2015-01, Vol.1851 (1), p.13-18

2015

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The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro

Frontiers in neuroscience, 2019-05, Vol.13, p.419

2019

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Small Discoidal Pre-β1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1

Biochemistry (Easton), 2009-11, Vol.48 (46), p.11067-11074

2009

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Depletion in LpA-I:A-II particles enhances HDL-mediated endothelial protection in familial LCAT deficiency[S]

Journal of lipid research, 2017-05, Vol.58 (5), p.994-1001

2017

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Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease

Journal of clinical medicine, 2020-07, Vol.9 (7), p.2289

2020

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Paradoxical fall in proteinuria during pregnancy in an LCAT-deficient patient—A case report

Journal of clinical lipidology, 2018-09, Vol.12 (5), p.1151-1156

2018

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Differential effects of fenofibrate and extended-release niacin on high-density lipoprotein particle size distribution and cholesterol efflux capacity in dyslipidemic patients

Journal of clinical lipidology, 2013-09, Vol.7 (5), p.414-422

2013

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Distant homology modeling of LCAT and its validation through in silico targeting and in vitro and in vivo assays

PloS one, 2014-04, Vol.9 (4), p.e95044-e95044

2014

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Plasma lecithin:cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk

Journal of lipid research, 2011-08, Vol.52 (8), p.1569-1574

2011

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Indicators of Cardiovascular Risk in Metabolic Syndrome: Long Term Follow-up in Italian Patients

Current vascular pharmacology, 2017-05, Vol.15 (3), p.248

2017

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Effect of the amyloidogenic L75P apolipoprotein A-I variant on HDL subpopulations

Clinica chimica acta, 2011-06, Vol.412 (13), p.1262-1265

2011

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Activation of Naturally Occurring Lecithin:Cholesterol Acyltransferase Mutants by a Novel Activator Compound

The Journal of pharmacology and experimental therapeutics, 2020-12, Vol.375 (3), p.463

2020

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Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia

Journal of clinical lipidology, 2012-05, Vol.6 (3), p.244-250

2012

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CER-001 ameliorates lipid profile and kidney disease in a mouse model of familial LCAT deficiency

Metabolism, clinical and experimental, 2021-03, Vol.116, p.154464-154464, Article 154464

2021

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Abdominal obesity negatively influences key metrics of reverse cholesterol transport

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2022-02, Vol.1867 (2), p.159087, Article 159087

2022

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Complete and Partial Lecithin: Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

Circulation (New York, N.Y.), 2018-09, Vol.138 (10), p.1000-1007

2018

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Recombinant LCAT (Lecithin:Cholesterol Acyltransferase) Rescues Defective HDL (High-Density Lipoprotein)-Mediated Endothelial Protection in Acute Coronary Syndrome

Arteriosclerosis, thrombosis, and vascular biology, 2019-05, Vol.39 (5), p.915

2019

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Topiramate protects apoE-deficient mice from kidney damage without affecting plasma lipids

Pharmacological research, 2019-03, Vol.141, p.189-200

2019

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A proteomic approach to identify novel disease biomarkers in LCAT deficiency

Journal of proteomics, 2019-04, Vol.198, p.113-118

2019

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Plasma PCSK9 levels and lipoprotein distribution are preserved in carriers of genetic HDL disorders

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2018-09, Vol.1863 (9), p.991-997

2018

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Persistent changes in lipoprotein lipids after a single infusion of ascending doses of MDCO-216 (apoA-IMilano/POPC) in healthy volunteers and stable coronary artery disease patients

Atherosclerosis, 2016-12, Vol.255, p.17-24

2016

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Characterization of three kindreds with familial combined hypolipidemia caused by loss-of-function mutations of ANGPTL3

Circulation. Cardiovascular genetics, 2012-02, Vol.5 (1), p.42

2012

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Role of LCAT in Atherosclerosis

Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease

HDL and atherosclerosis: Insights from inherited HDL disorders

The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro

Small Discoidal Pre-β1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1

Depletion in LpA-I:A-II particles enhances HDL-mediated endothelial protection in familial LCAT deficiency[S]

Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease

Paradoxical fall in proteinuria during pregnancy in an LCAT-deficient patient—A case report

Differential effects of fenofibrate and extended-release niacin on high-density lipoprotein particle size distribution and cholesterol efflux capacity in dyslipidemic patients

Distant homology modeling of LCAT and its validation through in silico targeting and in vitro and in vivo assays

Plasma lecithin:cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk

Indicators of Cardiovascular Risk in Metabolic Syndrome: Long Term Follow-up in Italian Patients

The Association between HDL-C and Subclinical Atherosclerosis Depends on CETP Plasma Concentration: Insights from the IMPROVE Study

Effect of the amyloidogenic L75P apolipoprotein A-I variant on HDL subpopulations

Activation of Naturally Occurring Lecithin:Cholesterol Acyltransferase Mutants by a Novel Activator Compound

Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia

CER-001 ameliorates lipid profile and kidney disease in a mouse model of familial LCAT deficiency

Abdominal obesity negatively influences key metrics of reverse cholesterol transport

Complete and Partial Lecithin: Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

Recombinant LCAT (Lecithin:Cholesterol Acyltransferase) Rescues Defective HDL (High-Density Lipoprotein)-Mediated Endothelial Protection in Acute Coronary Syndrome

Topiramate protects apoE-deficient mice from kidney damage without affecting plasma lipids

A proteomic approach to identify novel disease biomarkers in LCAT deficiency

Plasma PCSK9 levels and lipoprotein distribution are preserved in carriers of genetic HDL disorders

Persistent changes in lipoprotein lipids after a single infusion of ascending doses of MDCO-216 (apoA-IMilano/POPC) in healthy volunteers and stable coronary artery disease patients

Characterization of three kindreds with familial combined hypolipidemia caused by loss-of-function mutations of ANGPTL3

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