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Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (25), p.10619-10624

2007

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Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass

The Journal of biological chemistry, 2003-01, Vol.278 (3), p.1998-2007

2003

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A Nonprostanoid EP4 Receptor Selective Prostaglandin E2 Agonist Restores Bone Mass and Strength in Aged, Ovariectomized Rats

Journal of bone and mineral research, 2006-04, Vol.21 (4), p.565-575

2006

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Discovery and Preclinical Pharmacology of a Novel, Potent, Nonsteroidal Estrogen Receptor Agonist/Antagonist, CP-336156, a Diaryltetrahydronaphthalene

Journal of medicinal chemistry, 1998-07, Vol.41 (16), p.2928-2931

1998

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Long-Term Treatment of Lasofoxifene Preserves Bone Mass and Bone Strength and Does Not Adversely Affect the Uterus in Ovariectomized Rats

Endocrinology (Philadelphia), 2004-04, Vol.145 (4), p.1996-2005

2004

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Parathyroid Hormone-Related Protein of Malignancy: Active Synthetic Fragments

Science (American Association for the Advancement of Science), 1987-12, Vol.238 (4833), p.1568-1570

1987

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A New Vitamin D Analog, 2MD, Restores Trabecular and Cortical Bone Mass and Strength in Ovariectomized Rats With Established Osteopenia

Journal of bone and mineral research, 2005-10, Vol.20 (10), p.1742-1755

2005

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Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor beta and androgen receptor in rats

Menopause (New York, N.Y.), 2006-07, Vol.13 (4), p.609-620

2006

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Effects of CP-336,156, a New, Nonsteroidal Estrogen Agonist/Antagonist, on Bone, Serum Cholesterol, Uterus, and Body Composition in Rat Models

Endocrinology (Philadelphia), 1998-04, Vol.139 (4), p.2068-2076

1998

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Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leukocytes

Science (American Association for the Advancement of Science), 1972-09, Vol.177 (4051), p.793-795

1972

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Lasofoxifene (CP-336,156), a Selective Estrogen Receptor Modulator, Prevents Bone Loss Induced by Aging and Orchidectomy in the Adult Rat

Endocrinology (Philadelphia), 2000-04, Vol.141 (4), p.1338-1344

2000

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Complement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption

Science (American Association for the Advancement of Science), 1974-08, Vol.185 (4153), p.789-791

1974

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The Effects of Parathyroid Hormone, Colchicine, and Calcitonin on the Ultrastructure and the Activity of Osteoclasts in Organ Culture

The Journal of cell biology, 1974-02, Vol.60 (2), p.346-355

1974

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Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats

Endocrinology (Philadelphia), 1995-06, Vol.136 (6), p.2435-2441

1995

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Effect of prostaglandin endoperoxides and metabolites on bone resorption in vitro

Nature (London), 1977, Vol.267 (5611), p.532-534

1977

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Effects of acid and basic fibroblast growth factor and heparin on resorption of cultured fetal rat long bones

Journal of bone and mineral research, 1991-12, Vol.6 (12), p.1301-1305

1991

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Initiation of bone resorption by the classical and alternative C pathways and its mediation by prostaglandins

The Journal of immunology (1950), 1977-10, Vol.119 (4), p.1378-1381

1977

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Droloxifene prevents ovariectomy‐induced bone loss in tibiae and femora of aged female rats: A dual‐energy X‐ray absorptiometric and histomorphometric study

Journal of bone and mineral research, 1995-08, Vol.10 (8), p.1256-1262

1995

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Effects of prostaglandin F2 alpha on bone formation and resorption in cultured neonatal mouse calvariae: role of prostaglandin E2 production

Endocrinology (Philadelphia), 1990-02, Vol.126 (2), p.1076-1079

1990

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Prostaglandin synthesis by fetal rat bone in vitro: Evidence for a role of prostacyclin

Prostaglandins, 1979-06, Vol.17 (6), p.905-914

1979

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Direct stimulation of bone resorption by epidermal growth factor

Endocrinology (Philadelphia), 1980-07, Vol.107 (1), p.270-273

1980

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Comparison of the effects of amino-terminal synthetic parathyroid hormone-related peptide (PTHrP) of malignancy and parathyroid hormone on resorption of cultured fetal rat long bones

Calcified tissue international, 1990-04, Vol.46 (4), p.233-238

1990

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Effects of Parathyroid Hormone and Cortisol on Prostaglandin Production by Neonatal rat Calvaria in Vitro

Endocrine research, 1985, Vol.11 (1-2), p.59-74

1985

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Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2

Biochemical and biophysical research communications, 1981-10, Vol.102 (4), p.1358-1365

1981

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Comparison of the effects of vitamin D metabolites on collagen synthesis and resportion of fetal rat bone in organ culture

Calcified tissue international, 1980-01, Vol.32 (2), p.135-138

1980

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Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass

A Nonprostanoid EP4 Receptor Selective Prostaglandin E2 Agonist Restores Bone Mass and Strength in Aged, Ovariectomized Rats

Discovery and Preclinical Pharmacology of a Novel, Potent, Nonsteroidal Estrogen Receptor Agonist/Antagonist, CP-336156, a Diaryltetrahydronaphthalene

Long-Term Treatment of Lasofoxifene Preserves Bone Mass and Bone Strength and Does Not Adversely Affect the Uterus in Ovariectomized Rats

Parathyroid Hormone-Related Protein of Malignancy: Active Synthetic Fragments

A New Vitamin D Analog, 2MD, Restores Trabecular and Cortical Bone Mass and Strength in Ovariectomized Rats With Established Osteopenia

Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor beta and androgen receptor in rats

Effects of CP-336,156, a New, Nonsteroidal Estrogen Agonist/Antagonist, on Bone, Serum Cholesterol, Uterus, and Body Composition in Rat Models

Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leukocytes

Lasofoxifene (CP-336,156), a Selective Estrogen Receptor Modulator, Prevents Bone Loss Induced by Aging and Orchidectomy in the Adult Rat

Complement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption

The Effects of Parathyroid Hormone, Colchicine, and Calcitonin on the Ultrastructure and the Activity of Osteoclasts in Organ Culture

Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats

Effect of prostaglandin endoperoxides and metabolites on bone resorption in vitro

Effects of acid and basic fibroblast growth factor and heparin on resorption of cultured fetal rat long bones

Initiation of bone resorption by the classical and alternative C pathways and its mediation by prostaglandins

Droloxifene prevents ovariectomy‐induced bone loss in tibiae and femora of aged female rats: A dual‐energy X‐ray absorptiometric and histomorphometric study

Effects of prostaglandin F2 alpha on bone formation and resorption in cultured neonatal mouse calvariae: role of prostaglandin E2 production

Prostaglandin synthesis by fetal rat bone in vitro: Evidence for a role of prostacyclin

Direct stimulation of bone resorption by epidermal growth factor

Comparison of the effects of amino-terminal synthetic parathyroid hormone-related peptide (PTHrP) of malignancy and parathyroid hormone on resorption of cultured fetal rat long bones

Effects of Parathyroid Hormone and Cortisol on Prostaglandin Production by Neonatal rat Calvaria in Vitro

Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2

Comparison of the effects of vitamin D metabolites on collagen synthesis and resportion of fetal rat bone in organ culture

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