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CDK7 inhibitors as anticancer drugs

Cancer and metastasis reviews, 2020-09, Vol.39 (3), p.805-823

2020

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Light-triggered enzymatic reactions in nested vesicle reactors

Nature communications, 2018-03, Vol.9 (1), p.1093-6, Article 1093

2018

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Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

Nature communications, 2017-11, Vol.8 (1), p.1865-15, Article 1865

2017

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Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts

Clinical cancer research, 2017-01, Vol.23 (1), p.88-96

2017

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The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation

Scientific reports, 2017-11, Vol.7 (1), p.16115-12, Article 16115

2017

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ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

Nature communications, 2022-04, Vol.13 (1), p.2011-2011, Article 2011

2022

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Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer

Breast cancer research : BCR, 2020-11, Vol.22 (1), p.126-126, Article 126

2020

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Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

Oncogene, 2022-04, Vol.41 (15), p.2139-2151

2022

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Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

Nature communications, 2022-08, Vol.13 (1), p.4975-4975, Article 4975

2022

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ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Molecular cancer therapeutics, 2018-06, Vol.17 (6), p.1156-1166

2018

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Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer

Clinical chemistry (Baltimore, Md.), 2015-07, Vol.61 (7), p.974-982

2015

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The Evolution of Affordable Technologies in Liquid Biopsy Diagnostics: The Key to Clinical Implementation

Cancers, 2023-11, Vol.15 (22), p.5434

2023

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Detection of Multiple Breast Cancer ESR1 Mutations on an ISFET Based Lab-on-Chip Platform

IEEE transactions on biomedical circuits and systems, 2021-06, Vol.15 (3), p.380-389

2021

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Endocrine-responsive breast cancer and strategies for combating resistance

Nature reviews. Cancer, 2002-02, Vol.2 (2), p.101-112

2002

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Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

Nature communications, 2015-11, Vol.6 (1), p.10044-10044, Article 10044

2015

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p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

Nucleic acids research, 2017-11, Vol.45 (19), p.11056-11069

2017

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Prognostic significance of androgen receptor expression in invasive breast cancer: transcriptomic and protein expression analysis

Breast cancer research and treatment, 2016-09, Vol.159 (2), p.215-227

2016

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The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo

Cancers, 2023-04, Vol.15 (8), p.2211

2023

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Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κB

Oncogene, 2021-02, Vol.40 (6), p.1077-1090

2021

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A Common Deletion in the APOBEC3 Genes and Breast Cancer Risk

JNCI : Journal of the National Cancer Institute, 2013-04, Vol.105 (8), p.573-579

2013

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ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942

Oncogene, 2020-01, Vol.39 (3), p.651-663

2020

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A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p.H1047R breast cancer mutation

Scientific reports, 2020-03, Vol.10 (1), p.4553, Article 4553

2020

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Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes

PloS one, 2016-02, Vol.11 (2), p.e0147990

2016

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Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

Nature communications, 2023-07, Vol.14 (1), p.4444-4444, Article 4444

2023

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Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

Scientific reports, 2024-03, Vol.14 (1), p.6873-6873, Article 6873

2024

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CDK7 inhibitors as anticancer drugs

Light-triggered enzymatic reactions in nested vesicle reactors

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts

The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer

Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer

The Evolution of Affordable Technologies in Liquid Biopsy Diagnostics: The Key to Clinical Implementation

Detection of Multiple Breast Cancer ESR1 Mutations on an ISFET Based Lab-on-Chip Platform

Endocrine-responsive breast cancer and strategies for combating resistance

Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

Prognostic significance of androgen receptor expression in invasive breast cancer: transcriptomic and protein expression analysis

The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo

Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κB

A Common Deletion in the APOBEC3 Genes and Breast Cancer Risk

ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942

A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p.H1047R breast cancer mutation

Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes

Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

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