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Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity

PloS one, 2015-06, Vol.10 (6), p.e0129087

2015

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The therapeutic potential of chemical chaperones in protein folding diseases

Prion, 2014-03, Vol.8 (2), p.197-202

2014

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PrP is cleaved from the surface of mast cells by ADAM10 and proteases released during degranulation

Journal of leukocyte biology, 2024-10, Vol.116 (4), p.838-853

2024

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Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm

PLoS pathogens, 2021-06, Vol.17 (6), p.e1009703-e1009703

2021

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Histamine stimulates human microglia to alter cellular prion protein expression via the HRH2 histamine receptor

Scientific reports, 2024-10, Vol.14 (1), p.25519-18, Article 25519

2024

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The most infectious prion protein particles

Nature, 2005-09, Vol.437 (7056), p.257-261

2005

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Mast Cell Proteases Cleave Prion Proteins and a Recombinant Ig against PrP Can Activate Human Mast Cells

The Journal of immunology (1950), 2023-05, Vol.210 (9), p.1447-1458

2023

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Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein

Nature communications, 2016-06, Vol.7 (1), p.12058-12058, Article 12058

2016

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Early increase and late decrease of purkinje cell dendritic spine density in prion-infected organotypic mouse cerebellar cultures

PloS one, 2013-12, Vol.8 (12), p.e81776-e81776

2013

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Native nanodiscs formed by styrene maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids

The Journal of biological chemistry, 2020-06, Vol.295 (25), p.8460-8469

2020

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The Mechanism of Membrane Disruption by Cytotoxic Amyloid Oligomers Formed by Prion Protein(106–126) Is Dependent on Bilayer Composition

The Journal of biological chemistry, 2014-04, Vol.289 (15), p.10419-10430

2014

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Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils

Neurobiology of aging, 2009-12, Vol.30 (12), p.2031-2042

2009

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From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics

Biomolecules (Basel, Switzerland), 2021-01, Vol.11 (1), p.106

2021

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Prion Disease: Chemotherapeutic Strategies

Infectious disorders drug targets, 2012-04, Vol.12 (2), p.144-160

L. Sim, Valerie

2012

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POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research

Biomolecules (Basel, Switzerland), 2020-07, Vol.10 (7), p.1079

2020

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Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein

Nature methods, 2007-08, Vol.4 (8), p.645-650

2007

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High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice

Antimicrobial agents and chemotherapy, 2018-08, Vol.62 (8)

2018

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In Vitro and In Vivo Evidence towards Fibronectin's Protective Effects against Prion Infection

International journal of molecular sciences, 2023-12, Vol.24 (24), p.17525

2023

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Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease

Journal of virology, 2015-08, Vol.89 (15), p.7660-7672

2015

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Exposure Risk of Chronic Wasting Disease in Humans

Viruses, 2020-12, Vol.12 (12), p.1454

2020

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Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology

Disease models & mechanisms, 2021-10, Vol.14 (10)

2021

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Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

Molecular neurodegeneration, 2024-05, Vol.19 (1), p.42-42, Article 42

2024

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Probing the origin of prion protein misfolding via reconstruction of ancestral proteins

Protein science, 2022-12, Vol.31 (12), p.e4477-n/a

2022

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Recent advances in prion chemotherapeutics

Infectious disorders drug targets, 2009-02, Vol.9 (1), p.81-91

2009

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Infectious prions accumulate to high levels in non proliferative C2C12 myotubes

PLoS pathogens, 2013-11, Vol.9 (11), p.e1003755-e1003755

2013

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Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity

The therapeutic potential of chemical chaperones in protein folding diseases

PrP is cleaved from the surface of mast cells by ADAM10 and proteases released during degranulation

Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm

Histamine stimulates human microglia to alter cellular prion protein expression via the HRH2 histamine receptor

The most infectious prion protein particles

Mast Cell Proteases Cleave Prion Proteins and a Recombinant Ig against PrP Can Activate Human Mast Cells

Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein

Early increase and late decrease of purkinje cell dendritic spine density in prion-infected organotypic mouse cerebellar cultures

Native nanodiscs formed by styrene maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids

The Mechanism of Membrane Disruption by Cytotoxic Amyloid Oligomers Formed by Prion Protein(106–126) Is Dependent on Bilayer Composition

Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils

From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics

Prion Disease: Chemotherapeutic Strategies

POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research

Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein

High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice

In Vitro and In Vivo Evidence towards Fibronectin's Protective Effects against Prion Infection

Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease

Exposure Risk of Chronic Wasting Disease in Humans

Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology

Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

Probing the origin of prion protein misfolding via reconstruction of ancestral proteins

Recent advances in prion chemotherapeutics

Infectious prions accumulate to high levels in non proliferative C2C12 myotubes

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