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PINK1/Parkin Pathway Activation for Mitochondrial Quality Control – Which Is the Best Molecular Target for Therapy?

Frontiers in aging neuroscience, 2022-06, Vol.14, p.890823-890823

Silvian, Laura F.

2022

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ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

PloS one, 2016-11, Vol.11 (11), p.e0165983-e0165983

2016

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Activation of parkin by a molecular glue

Nature communications, 2024-09, Vol.15 (1), p.7707-12, Article 7707

2024

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Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Bioorganic & medicinal chemistry, 2013-07, Vol.21 (14), p.4011-4019

2013

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Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Bioorganic & medicinal chemistry letters, 2023-01, Vol.80, p.129108, Article 129108

2023

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Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

iScience, 2022-01, Vol.25 (1), p.103650-103650, Article 103650

2022

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Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

Protein science, 2010-03, Vol.19 (3), p.429-439

2010

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Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure

Protein science, 2018-03, Vol.27 (3), p.672-680

2018

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Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Scientific reports, 2018-09, Vol.8 (1), p.13438-10, Article 13438

2018

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Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

Protein science, 2010-05, Vol.19 (5), p.954-966

2010

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Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

Structure (London), 2008-05, Vol.16 (5), p.798-808

2008

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Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

BMC structural biology, 2016-06, Vol.16 (1), p.7-7, Article 7

2016

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Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

Protein science, 2017-02, Vol.26 (2), p.152-162

2017

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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus

Nature structural & molecular biology, 2001-11, Vol.8 (11), p.984-989

2001

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Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

ACS chemical biology, 2011-06, Vol.6 (6), p.636-647

2011

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How can the structure of germinal-center kinase-like kinase help us in drug discovery?

Future medicinal chemistry, 2017-09, Vol.9 (14), p.1583-1585

Silvian, Laura

2017

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Formation of Virus-like Clusters Is an Intrinsic Property of the Tumor Necrosis Factor Family Member BAFF (B Cell Activating Factor)

Biochemistry (Easton), 2006-02, Vol.45 (7), p.2006-2013

2006

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How glutaminyl-tRNA synthetase selects glutamine

Structure (London), 1998-04, Vol.6 (4), p.439-449

1998

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A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43780-43788

2004

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New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors

Current topics in medicinal chemistry, 2005-06, Vol.5 (6), p.577-583

2005

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Correction to Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

ACS chemical biology, 2011-07, Vol.6 (7), p.761-761

2011

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Inhibitors of protein–protein interactions: New methodologies to tackle this challenge

Drug discovery today. Technologies, 2013-12, Vol.10 (4), p.e509-e515

2013

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Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA$^{Ile}$ and Mupirocin

Science (American Association for the Advancement of Science), 1999-08, Vol.285 (5430), p.1074-1077

1999

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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (13), p.2905-2913

2019

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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Bioorganic & medicinal chemistry, 2021-08, Vol.44, p.116275-116275, Article 116275

2021

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PINK1/Parkin Pathway Activation for Mitochondrial Quality Control – Which Is the Best Molecular Target for Therapy?

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Activation of parkin by a molecular glue

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

How can the structure of germinal-center kinase-like kinase help us in drug discovery?

Formation of Virus-like Clusters Is an Intrinsic Property of the Tumor Necrosis Factor Family Member BAFF (B Cell Activating Factor)

How glutaminyl-tRNA synthetase selects glutamine

A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin

New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors

Correction to Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

Inhibitors of protein–protein interactions: New methodologies to tackle this challenge

Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA$^{Ile}$ and Mupirocin

Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

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