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Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions

Chemical reviews, 2018-04, Vol.118 (7), p.4037-4070

Silverman, Richard B

2018

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From Basic Science to Blockbuster Drug: The Discovery of Lyrica

Angewandte Chemie (International ed.), 2008-04, Vol.47 (19), p.3500-3504

Silverman, Richard B

2008

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Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

Chemical Society reviews, 2014-10, Vol.43 (19), p.6814-6838

2014

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A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease

Science translational medicine, 2019-10, Vol.11 (514)

2019

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Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases

Accounts of chemical research, 2009-03, Vol.42 (3), p.439-451

Silverman, Richard B

2009

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Inactivators of Ornithine Aminotransferase for the Treatment of Hepatocellular Carcinoma

ACS medicinal chemistry letters, 2022-01, Vol.13 (1), p.38-49

Silverman, Richard B

2022

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The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia

PloS one, 2015-01, Vol.10 (1), p.e0116919

2015

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The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

Cell reports (Cambridge), 2012-12, Vol.2 (6), p.1492-1497

2012

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American Academy of Orthopaedic Surgeons Clinical Practice Guideline Case Study: Management of Anterior Cruciate Ligament Injuries

Journal of the American Academy of Orthopaedic Surgeons, 2023-06, Vol.31 (11), p.538

2023

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The 2011 E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances: (1S,3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a GABA Aminotransferase Inactivator and New Treatment for Drug Addiction and Infantile Spasms

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.567-575

Silverman, Richard B

2012

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Potent, Selective, and Membrane Permeable 2‑Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9934-9953

2023

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Improved synthesis and anticancer activity of a potent neuronal nitric oxide synthase inhibitor

Bioorganic & medicinal chemistry letters, 2023-06, Vol.90, p.129329-129329, Article 129329

2023

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Interaction of Candida albicans Cell Wall Als3 Protein with Streptococcus gordonii SspB Adhesin Promotes Development of Mixed-Species Communities

Infection and Immunity, 2010-11, Vol.78 (11), p.4644-4652

2010

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OV329, a novel highly potent γ‐aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala‐kindled rats

Epilepsia (Copenhagen), 2021-12, Vol.62 (12), p.3091-3104

2021

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Revisiting Heme Mechanisms. A Perspective on the Mechanisms of Nitric Oxide Synthase (NOS), Heme Oxygenase (HO), and Cytochrome P450s (CYP450s)

Biochemistry (Easton), 2008-02, Vol.47 (8), p.2231-2243

2008

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Optimization of Blood–Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2‑Aminopyridine Scaffold

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2690-2707

2019

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First Contact: 7‑Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4528-4554

2020

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CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

Nature communications, 2012, Vol.3 (1), p.1146-7, Article 1146

2012

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Editorial Commentary: Preoperative Patient-Reported Outcomes Measurement Information System Scores Predict Which Patients Will Benefit From Arthroscopic Meniscectomy: To Scope or Not to Scope?

Arthroscopy, 2021-03, Vol.37 (3), p.972-975

2021

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2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors

Bioorganic & medicinal chemistry, 2022-09, Vol.69, p.116878-116878, Article 116878

2022

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Synthesis of (S)‑3-Amino-4-(difluoromethylenyl)-cyclopent-1-ene-1-carboxylic Acid (OV329), a Potent Inactivator of γ‑Aminobutyric Acid Aminotransferase

Organic letters, 2018-08, Vol.20 (15), p.4589-4592

2018

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Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)

Scientific reports, 2022-02, Vol.12 (1), p.1701-1701, Article 1701

2022

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Physiological involvement of presynaptic L‐type voltage‐dependent calcium channels in GABA release of cerebellar molecular layer interneurons

Journal of neurochemistry, 2020-11, Vol.155 (4), p.390-402

2020

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Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells

PloS one, 2015-09, Vol.10 (9), p.e0137753-e0137753

2015

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Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase

Biochemistry (Easton), 2024-03, Vol.63 (6), p.788-796

2024

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Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions

From Basic Science to Blockbuster Drug: The Discovery of Lyrica

Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease

Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases

Inactivators of Ornithine Aminotransferase for the Treatment of Hepatocellular Carcinoma

The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

American Academy of Orthopaedic Surgeons Clinical Practice Guideline Case Study: Management of Anterior Cruciate Ligament Injuries

The 2011 E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances: (1S,3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a GABA Aminotransferase Inactivator and New Treatment for Drug Addiction and Infantile Spasms

Potent, Selective, and Membrane Permeable 2‑Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors

Improved synthesis and anticancer activity of a potent neuronal nitric oxide synthase inhibitor

Interaction of Candida albicans Cell Wall Als3 Protein with Streptococcus gordonii SspB Adhesin Promotes Development of Mixed-Species Communities

OV329, a novel highly potent γ‐aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala‐kindled rats

Revisiting Heme Mechanisms. A Perspective on the Mechanisms of Nitric Oxide Synthase (NOS), Heme Oxygenase (HO), and Cytochrome P450s (CYP450s)

Optimization of Blood–Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2‑Aminopyridine Scaffold

First Contact: 7‑Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

Editorial Commentary: Preoperative Patient-Reported Outcomes Measurement Information System Scores Predict Which Patients Will Benefit From Arthroscopic Meniscectomy: To Scope or Not to Scope?

2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors

Synthesis of (S)‑3-Amino-4-(difluoromethylenyl)-cyclopent-1-ene-1-carboxylic Acid (OV329), a Potent Inactivator of γ‑Aminobutyric Acid Aminotransferase

Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)

Physiological involvement of presynaptic L‐type voltage‐dependent calcium channels in GABA release of cerebellar molecular layer interneurons

Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells

Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase

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