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Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

Clinical cancer research, 2011-12, Vol.17 (24), p.7614-7624

2011

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The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A‐Dependent

Journal of bone and mineral research, 2017-12, Vol.32 (12), p.2489-2499

2017

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Antitumor Activity of the Investigational Proteasome Inhibitor MLN9708 in Mouse Models of B-cell and Plasma Cell Malignancies

Clinical cancer research, 2011-12, Vol.17 (23), p.7313-7323

2011

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The relationship among tumor architecture, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in mouse xenograft models

Molecular cancer therapeutics, 2009-12, Vol.8 (12), p.3234-3243

2009

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Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain

Magnetic resonance in medicine, 2002-11, Vol.48 (5), p.826-837

2002

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Multimodal imaging with (18)F-FDG PET and Cerenkov luminescence imaging after MLN4924 treatment in a human lymphoma xenograft model

The Journal of nuclear medicine (1978), 2011-11, Vol.52 (11), p.1764-1769

2011

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Molecular Simulation of Receptor Occupancy and Tumor Penetration of an Antibody and Smaller Scaffolds: Application to Molecular Imaging

Molecular imaging and biology, 2017-10, Vol.19 (5), p.656-664

2017

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A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer

Cancer research (Chicago, Ill.), 2004-11, Vol.64 (21), p.7995-8001

2004

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Assessing antibody pharmacokinetics in mice with in vivo imaging

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.350-358

2011

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Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery

JCI insight, 2016-02, Vol.1 (2), p.e85311-e85311

2016

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Response-Derived Input Function Estimation for Dynamic Contrast-Enhanced MRI Demonstrated by Anti-DLL4 Treatment in a Murine U87 Xenograft Model

Molecular imaging and biology, 2017-10, Vol.19 (5), p.673-682

2017

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Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology

Stroke (1970), 2000-04, Vol.31 (4), p.946-954

2000

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Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis

Molecular imaging, 2006-10, Vol.5 (4), p.475-484

2006

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Perspectives on molecular and anatomical imaging in drug discovery

BioTechniques, 2005-12, Vol.39 (6), p.S26-S32

2005

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Evaluation of the antitumor effects of rilotumumab by PET imaging in a U-87 MG mouse xenograft model

Nuclear medicine and biology, 2013-05, Vol.40 (4), p.458-463

2013

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The macrosphere model: Evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats

Journal of neuroscience methods, 2003-01, Vol.122 (2), p.201-211

2003

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Regional, kinetic [(18)F]FDG PET imaging of a unilateral Parkinsonian animal model

American journal of nuclear medicine and molecular imaging, 2013-01, Vol.3 (2), p.129-141

2013

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Multispectral analysis of the temporal evolution of cerebral ischemia in the rat brain

Journal of magnetic resonance imaging, 2000-12, Vol.12 (6), p.842-858

2000

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Quantitative Analysis of Micro-CT Imaging and Histopathological Signatures of Experimental Arthritis in Rats

Molecular imaging, 2004-10, Vol.3 (4), p.312-318

2004

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Acute Postischemic Renormalization of the Apparent Diffusion Coefficient of Water is not Associated with Reversal of Astrocytic Swelling and Neuronal Shrinkage in Rats

American journal of neuroradiology : AJNR, 2002-02, Vol.23 (2), p.180-188

2002

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Spiculated periosteal response induced by intraosseous injection of 22Rv1 prostate cancer cells resembles subset of bone metastases in prostate cancer patients

The Prostate, 2005-12, Vol.65 (4), p.347-354

2005

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Longitudinally quantitative 2-deoxy-2-[18F]fluoro-D-glucose micro positron emission tomography imaging for efficacy of new anticancer drugs: a case study with bortezomib in prostate cancer murine model

Molecular imaging and biology, 2006-09, Vol.8 (5), p.300-308

2006

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Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (adc) maps with histology in focal cerebral ischemia of rats

Magnetic resonance imaging, 2004-06, Vol.22 (5), p.653-659

2004

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MRI in preclinical drug development

Methods in molecular medicine, 2006, Vol.124, p.299

2006

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Multimodal Imaging with 18 F-FDG PET and Cerenkov Luminescence Imaging After MLN4924 Treatment in a Human Lymphoma Xenograft Model

Journal of Nuclear Medicine, 2011-11, Vol.52 (11), p.1764-1769

2011

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Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A‐Dependent

Antitumor Activity of the Investigational Proteasome Inhibitor MLN9708 in Mouse Models of B-cell and Plasma Cell Malignancies

The relationship among tumor architecture, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in mouse xenograft models

Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain

Multimodal imaging with (18)F-FDG PET and Cerenkov luminescence imaging after MLN4924 treatment in a human lymphoma xenograft model

Molecular Simulation of Receptor Occupancy and Tumor Penetration of an Antibody and Smaller Scaffolds: Application to Molecular Imaging

A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer

Assessing antibody pharmacokinetics in mice with in vivo imaging

Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery

Response-Derived Input Function Estimation for Dynamic Contrast-Enhanced MRI Demonstrated by Anti-DLL4 Treatment in a Murine U87 Xenograft Model

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology

Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis

Perspectives on molecular and anatomical imaging in drug discovery

Evaluation of the antitumor effects of rilotumumab by PET imaging in a U-87 MG mouse xenograft model

The macrosphere model: Evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats

Regional, kinetic [(18)F]FDG PET imaging of a unilateral Parkinsonian animal model

Multispectral analysis of the temporal evolution of cerebral ischemia in the rat brain

Quantitative Analysis of Micro-CT Imaging and Histopathological Signatures of Experimental Arthritis in Rats

Acute Postischemic Renormalization of the Apparent Diffusion Coefficient of Water is not Associated with Reversal of Astrocytic Swelling and Neuronal Shrinkage in Rats

Spiculated periosteal response induced by intraosseous injection of 22Rv1 prostate cancer cells resembles subset of bone metastases in prostate cancer patients

Longitudinally quantitative 2-deoxy-2-[18F]fluoro-D-glucose micro positron emission tomography imaging for efficacy of new anticancer drugs: a case study with bortezomib in prostate cancer murine model

Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (adc) maps with histology in focal cerebral ischemia of rats

MRI in preclinical drug development

Multimodal Imaging with 18 F-FDG PET and Cerenkov Luminescence Imaging After MLN4924 Treatment in a Human Lymphoma Xenograft Model

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