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MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

Pharmaceutical research, 2015-06, Vol.32 (6), p.1975-1992

2015

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Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials

Clinical pharmacology and therapeutics, 2017-12, Vol.102 (6), p.961-969

2017

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Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters

Clinical pharmacology and therapeutics, 2017-04, Vol.101 (4), p.501-509

2017

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Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym®, a Mechanistic Model of Drug‐Induced Liver Injury

CPT: pharmacometrics and systems pharmacology, 2016-01, Vol.5 (1), p.31-39

2016

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A Mechanistic Model of Drug‐Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

CPT: pharmacometrics and systems pharmacology, 2014-02, Vol.3 (2), p.1-8

2014

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De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption

The American journal of clinical nutrition, 1999-11, Vol.70 (5), p.928-936

1999

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Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

CPT: pharmacometrics and systems pharmacology, 2014-07, Vol.3 (7), p.1-8

2014

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Advances in the Stable Isotope–Mass Spectrometric Measurement of DNA Synthesis and Cell Proliferation

Analytical biochemistry, 2001-11, Vol.298 (2), p.189-195

2001

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The inhibition of gluconeogenesis following alcohol in humans

American journal of physiology: endocrinology and metabolism, 1998-11, Vol.275 (5), p.E897-E907

1998

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VLDL-triglyceride production after alcohol ingestion, studied using [2-13C1] glycerol

Journal of lipid research, 1998-12, Vol.39 (12), p.2319-2328

1998

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The inhibition of gluconeogenesis following alcohol in humans

American journal of physiology: endocrinology and metabolism, 1998-11, Vol.38 (5), p.E897-E907

1998

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Applications of Quantitative Systems Pharmacology (QSP) in Drug Development for NAFLD and NASH and Its Regulatory Application

Pharmaceutical research, 2022-08, Vol.39 (8), p.1789-1802

Siler, Scott Q.

2022

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Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

Toxicological sciences, 2022-06, Vol.188 (1), p.108-116

2022

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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

Toxicological sciences, 2017-01, Vol.155 (1), p.61-74

2017

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Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)

Clinical pharmacology and therapeutics, 2023-02, Vol.113 (2), p.275-297

2023

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Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.443-459

2016

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Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

Pharmaceutical research, 2019-03, Vol.36 (3), p.48-12, Article 48

2019

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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

International journal of molecular sciences, 2023-06, Vol.24 (11), p.9692

2023

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Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition

Frontiers in pharmacology, 2023-01, Vol.13, p.1085621

2023

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The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury

Drug metabolism and pharmacokinetics, 2017-02, Vol.32 (1), p.40-45

2017

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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Toxicological sciences, 2019-02, Vol.167 (2), p.458-467

2019

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Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

Frontiers in pharmacology, 2014, Vol.5, p.240-240

2014

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Syllable processing is organized in discrete subregions of the human superior temporal gyrus

PLoS biology, 2024-09, Vol.22 (9), p.e3002774

2024

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Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

Biopharmaceutics & drug disposition, 2014-01, Vol.35 (1), p.33-49

2014

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MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials

Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters

Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym®, a Mechanistic Model of Drug‐Induced Liver Injury

A Mechanistic Model of Drug‐Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

Advances in the Stable Isotope–Mass Spectrometric Measurement of DNA Synthesis and Cell Proliferation

The inhibition of gluconeogenesis following alcohol in humans

VLDL-triglyceride production after alcohol ingestion, studied using [2-13C1] glycerol

The inhibition of gluconeogenesis following alcohol in humans

Applications of Quantitative Systems Pharmacology (QSP) in Drug Development for NAFLD and NASH and Its Regulatory Application

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

Phylogenetic partitioning of the third-largest vertebrate genus in the world, Cyrtodactylus Gray, 1827 (Reptilia; Squamata; Gekkonidae) and its relevance to taxonomy and conservation

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition

The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

Syllable processing is organized in discrete subregions of the human superior temporal gyrus

Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

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