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Gene Disruption Confirms a Critical Role for the Cysteine Protease Falcipain-2 in Hemoglobin Hydrolysis by Plasmodium falciparum

Proceedings of the National Academy of Sciences - PNAS, 2004-03, Vol.101 (13), p.4384-4389

2004

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Oleuropein activates autophagy to circumvent anti-plasmodial defense

iScience, 2024-04, Vol.27 (4), p.109463-109463, Article 109463

2024

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The Plasmodium falciparum Cysteine Protease Falcipain-2 Captures Its Substrate, Hemoglobin, via a Unique Motif

Proceedings of the National Academy of Sciences - PNAS, 2005-06, Vol.102 (26), p.9138-9143

2005

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The Ionic and hydrophobic interactions are required for the auto activation of cysteine proteases of Plasmodium falciparum

PloS one, 2012-10, Vol.7 (10), p.e47227

2012

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Structural Basis for Unique Mechanisms of Folding and Hemoglobin Binding by a Malarial Protease

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (31), p.11503-11508

2006

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Falcipain Cysteine Proteases Require Bipartite Motifs for Trafficking to the Plasmodium falciparum Food Vacuole

The Journal of biological chemistry, 2007-08, Vol.282 (34), p.24961-24969

2007

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Plasmodium falciparum Cysteine Protease Falcipain-1 Is Not Essential in Erythrocytic Stage Malaria Parasites

Proceedings of the National Academy of Sciences - PNAS, 2004-06, Vol.101 (23), p.8721-8726

2004

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Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum

Molecular and biochemical parasitology, 2006-11, Vol.150 (1), p.96-106

2006

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Independent Intramolecular Mediators of Folding, Activity, and Inhibition for the Plasmodium falciparum Cysteine Protease Falcipain-2

The Journal of biological chemistry, 2004-01, Vol.279 (5), p.3484-3491

2004

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Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax

Biochemical journal, 2004-03, Vol.378 (Pt 2), p.529-538

2004

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Folding of the Plasmodium falciparum Cysteine Protease Falcipain-2 Is Mediated by a Chaperone-like Peptide and Not the Prodomain

The Journal of biological chemistry, 2002-04, Vol.277 (17), p.14910-14915

2002

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Plasmodium falciparum: Biochemical characterization of the cysteine protease falcipain-2

Experimental parasitology, 2006-03, Vol.112 (3), p.187-192

2006

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A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2

Protein engineering, design and selection, 2007-04, Vol.20 (4), p.171-177

2007

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Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites

Biochemical journal, 2002-11, Vol.368 (Pt 1), p.273-281

2002

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Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum

The Journal of biological chemistry, 2000-09, Vol.275 (37), p.29000-29010

2000

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Cysteine proteases of malaria parasites: targets for chemotherapy

Current pharmaceutical design, 2002-08, Vol.8 (18), p.1659-1672

2002

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Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

Biochemical journal, 2001-12, Vol.360 (2), p.481-489

2001

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Characterization of Native and Recombinant Falcipain-2, a Principal Trophozoite Cysteine Protease and Essential Hemoglobinase ofPlasmodium falciparum

The Journal of biological chemistry, 2000-09, Vol.275 (37), p.29000-29010

2000

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Systematic Optimization of Expression and Refolding of the Plasmodium falciparum Cysteine Protease Falcipain-2

Protein expression and purification, 2001-06, Vol.22 (1), p.128-134

2001

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Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1

Molecular and biochemical parasitology, 2001-08, Vol.116 (1), p.95-99

2001

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Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodum falciparum

Proceedings of the National Academy of Sciences - PNAS, 2004-03, Vol.101 (13), p.4384

2004

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Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

Biochemical journal, 2001-12, Vol.360 (Pt 2), p.481-489

2001

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Cysteine Proteases

Reference Module in Life Sciences, 2017

2017

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Interaction with complement proteins and dendritic cells implicates LCCL domain-containing proteins (CCps) of malaria parasites in immunomodulation

Biochemical journal, 2018-11, Vol.475 (21), p.3311-3314

Sijwali, Puran Singh

2018

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Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity

PLoS pathogens, 2024-02, Vol.20 (2), p.e1012045-e1012045

2024

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Gene Disruption Confirms a Critical Role for the Cysteine Protease Falcipain-2 in Hemoglobin Hydrolysis by Plasmodium falciparum

Oleuropein activates autophagy to circumvent anti-plasmodial defense

The Plasmodium falciparum Cysteine Protease Falcipain-2 Captures Its Substrate, Hemoglobin, via a Unique Motif

The Ionic and hydrophobic interactions are required for the auto activation of cysteine proteases of Plasmodium falciparum

Structural Basis for Unique Mechanisms of Folding and Hemoglobin Binding by a Malarial Protease

Falcipain Cysteine Proteases Require Bipartite Motifs for Trafficking to the Plasmodium falciparum Food Vacuole

Plasmodium falciparum Cysteine Protease Falcipain-1 Is Not Essential in Erythrocytic Stage Malaria Parasites

Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum

Independent Intramolecular Mediators of Folding, Activity, and Inhibition for the Plasmodium falciparum Cysteine Protease Falcipain-2

Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax

Folding of the Plasmodium falciparum Cysteine Protease Falcipain-2 Is Mediated by a Chaperone-like Peptide and Not the Prodomain

Plasmodium falciparum: Biochemical characterization of the cysteine protease falcipain-2

A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2

Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites

Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum

Cysteine proteases of malaria parasites: targets for chemotherapy

Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

Characterization of Native and Recombinant Falcipain-2, a Principal Trophozoite Cysteine Protease and Essential Hemoglobinase ofPlasmodium falciparum

Systematic Optimization of Expression and Refolding of the Plasmodium falciparum Cysteine Protease Falcipain-2

Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1

Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodum falciparum

Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

Cysteine Proteases

Interaction with complement proteins and dendritic cells implicates LCCL domain-containing proteins (CCps) of malaria parasites in immunomodulation

Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity

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