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Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP‐Dependent Protein Kinase

Chembiochem : a European journal of chemical biology, 2022-04, Vol.23 (7), p.e202100704-n/a

2022

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A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Nature (London), 1989-10, Vol.341 (6244), p.755-757

1989

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Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase

ACS medicinal chemistry letters, 2021-12, Vol.12 (12), p.1962-1967

2021

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Expression, purification and enzymatic characterization of Brugia malayi dihydrofolate reductase

Protein expression and purification, 2016-12, Vol.128, p.81-85

2016

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Imidazopyrimidines, potent inhibitors of p38 MAP kinase

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.347-350

2003

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Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor

AIDS (London), 2004-03, Vol.18 (5), p.739-748

2004

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Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase

RSC medicinal chemistry, 2020-01, Vol.11 (1), p.98-101

2020

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Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

ACS medicinal chemistry letters, 2018-03, Vol.9 (3), p.210-214

2018

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The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses

Molecular and biochemical parasitology, 2011-04, Vol.176 (2), p.90-97

2011

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Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

Experimental parasitology, 2011-06, Vol.128 (2), p.170-175

2011

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RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

The Journal of pharmacology and experimental therapeutics, 1999-11, Vol.291 (2), p.680

1999

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HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

Blood, 2005-09, Vol.106 (6), p.2059-2068

2005

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Apicomplexa, trypanosoma and parasitic nematode protein kinases as antiparasitic therapeutic targets

Current opinion in investigational drugs (London, England : 2000), 2010-02, Vol.11 (2), p.147

2010

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Detergent-salt resistance of LAP2α in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics

The EMBO journal, 1998-08, Vol.17 (16), p.4887-4902

1998

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6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase Inhibitor

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4196-4198

1998

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Characterization of Competitive Inhibitors of P. falciparum cGMP-Dependent Protein Kinase

Chembiochem : a European journal of chemical biology, 2022-02, Vol.23 (7), p.e202100704-e202100704

2022

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Kinetics of small molecule inhibitor binding to p38 kinase

European journal of biochemistry, 2001-11, Vol.268 (22), p.5747-5754

2001

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FK-506 and cyclosporin A : immunosuppressive mechanism of action and beyond

Current opinion in immunology, 1992, Vol.4 (5), p.548-552

1992

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Leishmania mexicana potential drug target

The FASEB journal, 2012-04, Vol.26 (S1)

2012

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Discovery of isoxazolyl-based inhibitors of cGMP-dependent protein kinase

RSC medicinal chemistry, 2020-01, Vol.11 (1), p.98-11

2020

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Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice

The Journal of experimental medicine, 1999-04, Vol.189 (7), p.1129-1138

1999

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Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

The Journal of experimental medicine, 1998-06, Vol.187 (12), p.2073-2079

1998

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p38 alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells

The Journal of immunology (1950), 1999-06, Vol.162 (12), p.7110-7119

1999

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The immunosuppressive and toxic effects of FK-506 are mechanistically related : pharmacology of a novel antagonist of FK-506 and rapamycin

The Journal of experimental medicine, 1992-09, Vol.176 (3), p.751-760

1992

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T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes

The Journal of immunology (1950), 1999-01, Vol.162 (2), p.659-668

1999

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Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP‐Dependent Protein Kinase

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase

Expression, purification and enzymatic characterization of Brugia malayi dihydrofolate reductase

Imidazopyrimidines, potent inhibitors of p38 MAP kinase

Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor

Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis

The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses

Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

Apicomplexa, trypanosoma and parasitic nematode protein kinases as antiparasitic therapeutic targets

Detergent-salt resistance of LAP2α in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics

6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase Inhibitor

Characterization of Competitive Inhibitors of P. falciparum cGMP-Dependent Protein Kinase

Kinetics of small molecule inhibitor binding to p38 kinase

FK-506 and cyclosporin A : immunosuppressive mechanism of action and beyond

Leishmania mexicana potential drug target

Discovery of isoxazolyl-based inhibitors of cGMP-dependent protein kinase

Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

p38 alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells

The immunosuppressive and toxic effects of FK-506 are mechanistically related : pharmacology of a novel antagonist of FK-506 and rapamycin

T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes

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