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New preclinical guidelines on drug effects on ventricular repolarization: Safety pharmacology comes of age

Journal of pharmacological and toxicological methods, 2004-05, Vol.49 (3), p.153-158

2004

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Pathophysiological Roles of Endothelin-1 in Dahl Salt-Sensitive Hypertension

Hypertension (Dallas, Tex. 1979), 1999-09, Vol.34 (3), p.514-519

1999

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Antihypertensive Effects of a Mixed Endothelin-A- and -B-Receptor Antagonist, J-104132, Were Augmented in the Presence of an AT1-Receptor Antagonist, MK-954

Journal of cardiovascular pharmacology, 2000, Vol.36 Suppl 1 (5 Suppl 1), p.S337-S341

2000

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Effects of BQ-123 on renal function and acute cyclosporine-induced renal dysfunction

Kidney international, 1994-01, Vol.45 (1), p.131-136

1994

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Safety pharmacology in 2010 and beyond: Survey of significant events of the past 10years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.7-15

2011

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Antihypertensive Effects of a Mixed Endothelin-A- and -B-Receptor Antagonist, J-104132, Were Augmented in the Presence of an AT1-Receptor Antagonist, MK-954

Journal of cardiovascular pharmacology, 2000, Vol.36 (5 Suppl 1), p.S337-S341

2000

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Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2413-2426

2003

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Pharmacology of losartan, an angiotensin II receptor antagonist, in animal models of hypertension

Journal of hypertension, 1995-07, Vol.13 Suppl 1 (1), p.S15-S21

1995

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Isoproterenol Antagonizes Prolongation of Refractory Period by the Class III Antiarrhythmic Agent E-4031 in Guinea Pig Myocytes Mechanism of Action

Circulation research, 1991-01, Vol.68 (1), p.77-84

1991

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Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2919-2922

1991

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Antithrombotic efficacy of recombinant tick anticoagulant peptide : a potent inhibitor of coagulation factor Xa in a primate model of arterial thrombosis

Circulation (New York, N.Y.), 1991-10, Vol.84 (4), p.1741-1748

1991

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Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts

Journal of molecular and cellular cardiology, 1989-08, Vol.21 (8), p.783-788

1989

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A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3207-3210

1993

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Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes

Journal of medicinal chemistry, 1994-12, Vol.37 (26), p.4464-4478

1994

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Characterization of recombinant tick anticoagulant peptide. A highly selective inhibitor of blood coagulation factor Xa

The Journal of biological chemistry, 1990-10, Vol.265 (29), p.17746-17752

1990

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Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys

American journal of physiology. Renal physiology, 1991-09, Vol.261 (3), p.512-F518

1991

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Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3595-3605

1993

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A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist

Journal of medicinal chemistry, 1994-11, Vol.37 (24), p.4068-4072

1994

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Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles

Journal of medicinal chemistry, 1993-03, Vol.36 (5), p.591-609

1993

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Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes

Journal of medicinal chemistry, 1995-09, Vol.38 (19), p.3741-3758

1995

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Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2692-2701

1991

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Selective factor Xa inhibition by recombinant antistasin prevents vascular graft thrombosis in baboons

Arteriosclerosis and thrombosis, 1992-08, Vol.12 (8), p.879-885

1992

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Ventricular Atrial Natriuretic Factor in the Cardiomyopathic Hamster Model of Congestive Heart Failure

Circulation research, 1988-01, Vol.62 (1), p.31-36

1988

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Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles

Journal of medicinal chemistry, 1993-12, Vol.36 (26), p.4230-4238

1993

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Antithrombotic activity of recombinant tick anticoagulant peptide and heparin in a rabbit model of venous thrombosis

Thrombosis research, 1993-08, Vol.71 (4), p.317-324

1993

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New preclinical guidelines on drug effects on ventricular repolarization: Safety pharmacology comes of age

Pathophysiological Roles of Endothelin-1 in Dahl Salt-Sensitive Hypertension

Antihypertensive Effects of a Mixed Endothelin-A- and -B-Receptor Antagonist, J-104132, Were Augmented in the Presence of an AT1-Receptor Antagonist, MK-954

Effects of BQ-123 on renal function and acute cyclosporine-induced renal dysfunction

Safety pharmacology in 2010 and beyond: Survey of significant events of the past 10years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society

Antihypertensive Effects of a Mixed Endothelin-A- and -B-Receptor Antagonist, J-104132, Were Augmented in the Presence of an AT1-Receptor Antagonist, MK-954

Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Pharmacology of losartan, an angiotensin II receptor antagonist, in animal models of hypertension

Isoproterenol Antagonizes Prolongation of Refractory Period by the Class III Antiarrhythmic Agent E-4031 in Guinea Pig Myocytes Mechanism of Action

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Antithrombotic efficacy of recombinant tick anticoagulant peptide : a potent inhibitor of coagulation factor Xa in a primate model of arterial thrombosis

Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts

A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor

Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes

Characterization of recombinant tick anticoagulant peptide. A highly selective inhibitor of blood coagulation factor Xa

Angiotensin II receptor subtypes in renal cortex of rats and rhesus monkeys

Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates

A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist

Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles

Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

Selective factor Xa inhibition by recombinant antistasin prevents vascular graft thrombosis in baboons

Ventricular Atrial Natriuretic Factor in the Cardiomyopathic Hamster Model of Congestive Heart Failure

Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles

Antithrombotic activity of recombinant tick anticoagulant peptide and heparin in a rabbit model of venous thrombosis

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