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Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2413-2426

2003

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Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.7-15

2011

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Pathophysiological Roles of Endothelin-1 in Dahl Salt-Sensitive Hypertension

Hypertension (Dallas, Tex. 1979), 1999-09, Vol.34 (3), p.514-519

1999

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Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2919-2922

1991

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Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles

Journal of medicinal chemistry, 1993-12, Vol.36 (26), p.4230-4238

1993

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(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3738-3742

1993

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Renin inhibitors containing C-termini derived from mercaptoheterocycles

Journal of medicinal chemistry, 1992-05, Vol.35 (11), p.2103-2112

1992

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Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes

Journal of medicinal chemistry, 1994-12, Vol.37 (26), p.4464-4478

1994

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Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes

Journal of medicinal chemistry, 1995-09, Vol.38 (19), p.3741-3758

1995

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Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2692-2701

1991

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Nuclear Imaging in Drug Discovery, Development, and Approval

1, 1993

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Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides

Journal of medicinal chemistry, 1993-12, Vol.36 (26), p.4239-4249

1993

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Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.887-900

1991

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Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids

Journal of medicinal chemistry, 1992-07, Vol.35 (15), p.2772-2781

1992

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New preclinical guidelines on drug effects on ventricular repolarization: Safety pharmacology comes of age

Journal of pharmacological and toxicological methods, 2004-05, Vol.49 (3), p.153-158

2004

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BRL 34915 (Cromakalim) Activates ATP-Sensitive K+ Current in Cardiac Muscle

Proceedings of the National Academy of Sciences - PNAS, 1988-11, Vol.85 (21), p.8360-8364

1988

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Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides. [Erratum to document cited in CA120(5):45190z]

Journal of medicinal chemistry, 1994-04, Vol.37 (7), p.1034-1034

1994

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Effects of a specific bradycardic agent (AQ-A39) and verapamil on beta-adrenergic responses in isolated guinea pig atria

Canadian journal of physiology and pharmacology, 1987-02, Vol.65 (2), p.146-151

1987

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Overview of Cardiac Inotropic Mechanisms

Journal of cardiovascular pharmacology, 1986, Vol.8 Suppl 9, p.S1-10

Siegl, Peter K. S

1986

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Influence of AQ-A39, a Bradycardic Agent, on Cardiovascular Responses to Isoproterenol in the Anesthetized Dog

Journal of cardiovascular pharmacology, 1987-02, Vol.9 (2), p.246-253

1987

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Positive inotropic responses in cardiac muscles: influence of stimulation frequency and species

Canadian journal of physiology and pharmacology, 1982-01, Vol.60 (1), p.33-40

1982

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Antagonism with dibenamine, D-600, and Ro 3-7894 to estimate dissociation constants and receptor reserves for cardiac adrenoceptors in isolated rabbit papillary muscles

Canadian journal of physiology and pharmacology, 1982-08, Vol.60 (8), p.1131-1137

1982

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Chronotropic Stimulation: A Primary Effector for Release of Atrial Natriuretic Factor

Circulation research, 1989-04, Vol.64 (4), p.799-805

1989

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Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors: Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society

Pathophysiological Roles of Endothelin-1 in Dahl Salt-Sensitive Hypertension

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles

(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists

Renin inhibitors containing C-termini derived from mercaptoheterocycles

Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes

Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

Nuclear Imaging in Drug Discovery, Development, and Approval

Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids

New preclinical guidelines on drug effects on ventricular repolarization: Safety pharmacology comes of age

BRL 34915 (Cromakalim) Activates ATP-Sensitive K+ Current in Cardiac Muscle

Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides. [Erratum to document cited in CA120(5):45190z]

Effects of a specific bradycardic agent (AQ-A39) and verapamil on beta-adrenergic responses in isolated guinea pig atria

Overview of Cardiac Inotropic Mechanisms

Influence of AQ-A39, a Bradycardic Agent, on Cardiovascular Responses to Isoproterenol in the Anesthetized Dog

Positive inotropic responses in cardiac muscles: influence of stimulation frequency and species

Antagonism with dibenamine, D-600, and Ro 3-7894 to estimate dissociation constants and receptor reserves for cardiac adrenoceptors in isolated rabbit papillary muscles

Chronotropic Stimulation: A Primary Effector for Release of Atrial Natriuretic Factor

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