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K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells

Cancer research (Chicago, Ill.), 2009-05, Vol.69 (9), p.3901-3909

2009

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(E)-1,3-Dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists

Journal of medicinal chemistry, 1992-06, Vol.35 (12), p.2342-2345

1992

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Stimulating action of KW‐5139 (Leu13‐motilin) on gastrointestinal motility in the rabbit

British journal of pharmacology, 1994-01, Vol.111 (1), p.288-294

1994

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Actions of adenosine A 2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

Psychopharmacology, 1999-11, Vol.147 (1), p.90-95

1999

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New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones

Journal of medicinal chemistry, 1992-12, Vol.35 (26), p.4866-4874

1992

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Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-[(R)-phenylisopropyl]adenosine-induced cognitive disturbance

Journal of medicinal chemistry, 1993-08, Vol.36 (17), p.2508-2518

1993

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Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility. 1

Journal of medicinal chemistry, 1993-03, Vol.36 (5), p.572-579

1993

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New antiinflammatory agents. 2. 5-Phenyl-3H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones: a new class of nonsteroidal antiinflammatory agents with potent activity like glucocorticoids

Journal of medicinal chemistry, 1992-07, Vol.35 (15), p.2863-2870

1992

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5-HT3 receptor antagonists. 1. New quinoline derivatives

Journal of medicinal chemistry, 1992-12, Vol.35 (26), p.4893-4902

1992

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Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

Psychopharmacologia, 1999-11, Vol.147 (1), p.90-95

1999

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Effect of oxatomide, an antiallergic agent, on QT interval in dogs

Arzneimittel-Forschung, 2001-01, Vol.51 (12), p.971-976

2001

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5-HT3 receptor antagonists. 2. 4-Hydroxy-3-quinolinecarboxylic acid derivatives

Journal of medicinal chemistry, 1993-03, Vol.36 (5), p.617

1993

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New bronchodilators. 1. 1,5-Substituted 1H-imidazo[4,5-c]quinolin-4(5H)-ones

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4045-4053

1992

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Enhancement by KW-5092, a Novel Gastroprokinetic Agent, of the Gastrointestinal Motor Activity in Dogs

Japanese Journal of Pharmacology, 1994, Vol.65 (2), p.131-142

1994

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Pharmacological Properties of KF18259, a Novel 5-HT3-Receptor Antagonist, in Rats: Inhibition of the Distal Colonic Function

The Japanese Journal of Pharmacology, 1993, Vol.63(4), pp.495-502

1993

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Enhancement by KW-5092, a Novel Gastroprokinetic Agent, of the Gastrointestinal Motor Activity in Dogs

The Japanese Journal of Pharmacology, 1994, Vol.65(2), pp.131-142

1994

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5-HT3 Receptor antagonists. 3. Quinoline derivatives which may be effective in the therapy of irritable bowel syndrome

Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3286-3292

1993

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7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist

Journal of medicinal chemistry, 1992-09, Vol.35 (19), p.3578-3581

1992

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Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility

Journal of medicinal chemistry, 1993-03, Vol.36 (5), p.572-579

1993

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Synthesis and in vitro gastrointestinal motility enhancing activity of 3-aryl-2-imidazolidinylidene propanedinitrile derivatives

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (4), p.615-618

1994

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Effect of olopatadine hydrochloride, a novel antiallergic agent, on the QT interval in dogs

Folia Pharmacologica Japonica, 2001, Vol.117(6), pp.401-409

2001

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Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility—III

Bioorganic & medicinal chemistry, 1995-03, Vol.3 (3), p.279-287

1995

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Synthesis of 2-imidazolidinylidene propanedenitrile derivatives as stimulators of gastrointestinal motility—II

Bioorganic & medicinal chemistry, 1994, Vol.2 (10), p.1107-1117

1994

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5-HT3 Receptor antagonists. 2. 4-Hydroxy-4-quinolinecarboxylic acid derivatives

Journal of medicinal chemistry, 1993-03, Vol.36 (5), p.617-626

1993

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高齢者に使用される医薬品の臨床評価法に関するガイドライン

ファルマシア, 1994/12/01, Vol.30(12), pp.1408-1410

市川, 俊治

1994

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K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells

(E)-1,3-Dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists

Stimulating action of KW‐5139 (Leu13‐motilin) on gastrointestinal motility in the rabbit

Actions of adenosine A 2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones

Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-[(R)-phenylisopropyl]adenosine-induced cognitive disturbance

Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility. 1

New antiinflammatory agents. 2. 5-Phenyl-3H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones: a new class of nonsteroidal antiinflammatory agents with potent activity like glucocorticoids

5-HT3 receptor antagonists. 1. New quinoline derivatives

Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

Effect of oxatomide, an antiallergic agent, on QT interval in dogs

5-HT3 receptor antagonists. 2. 4-Hydroxy-3-quinolinecarboxylic acid derivatives

New bronchodilators. 1. 1,5-Substituted 1H-imidazo[4,5-c]quinolin-4(5H)-ones

Enhancement by KW-5092, a Novel Gastroprokinetic Agent, of the Gastrointestinal Motor Activity in Dogs

Pharmacological Properties of KF18259, a Novel 5-HT3-Receptor Antagonist, in Rats: Inhibition of the Distal Colonic Function

Enhancement by KW-5092, a Novel Gastroprokinetic Agent, of the Gastrointestinal Motor Activity in Dogs

5-HT3 Receptor antagonists. 3. Quinoline derivatives which may be effective in the therapy of irritable bowel syndrome

7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist

Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility

Synthesis and in vitro gastrointestinal motility enhancing activity of 3-aryl-2-imidazolidinylidene propanedinitrile derivatives

Effect of olopatadine hydrochloride, a novel antiallergic agent, on the QT interval in dogs

Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility—III

Synthesis of 2-imidazolidinylidene propanedenitrile derivatives as stimulators of gastrointestinal motility—II

5-HT3 Receptor antagonists. 2. 4-Hydroxy-4-quinolinecarboxylic acid derivatives

高齢者に使用される医薬品の臨床評価法に関するガイドライン

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