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Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes

The Journal of biological chemistry, 2020-10, Vol.295 (44), p.15158-15171

2020

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Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission

Scientific reports, 2023-10, Vol.13 (1), p.17067-17067, Article 17067

2023

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Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo

ACS chemical biology, 2018-06, Vol.13 (6), p.1551-1559

2018

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Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases

The Prostate, 2011-05, Vol.71 (6), p.615-625

2011

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Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor

Viruses, 2022-09, Vol.14 (9), p.2025

2022

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midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice

The FASEB journal, 2010-06, Vol.24 (6), p.1947-1957

2010

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Characterization of bone resorption in novel in vitro and in vivo models of oral squamous cell carcinoma

Oral oncology, 2012-06, Vol.48 (6), p.491-499

2012

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HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.5163-5174

2020

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PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication

Cell chemical biology, 2024-04, Vol.31 (4), p.658-668.e14

2024

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Development of a brain metastatic canine prostate cancer cell line

The Prostate, 2011-09, Vol.71 (12), p.1251-1263

2011

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Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation

The Journal of biological chemistry, 2017-02, Vol.292 (7), p.2670-2678

2017

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Nef defect attenuates HIV viremia and immune dysregulation in the bone marrow-liver-thymus-spleen (BLTS) humanized mouse model

Virology (New York, N.Y.), 2024-10, Vol.598, p.110192, Article 110192

2024

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Visualization of Host Cell Kinase Activation by Viral Proteins Using GFP Fluorescence Complementation and Immunofluorescence Microscopy

Bio-protocol, 2021-07, Vol.11 (13), p.e4068-e4068

2021

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Parathyroid hormone-related protein promotes bone loss in T-cell leukemia as well as in solid tumors

Leukemia & lymphoma, 2020-01, Vol.61 (2), p.409-419

2020

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Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (5), p.1480-1484

2016

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Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation

Retrovirology, 2008-06, Vol.5 (1), p.46-46, Article 46

2008

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Function and Regulatory Mechanisms of the Candidate Tumor Suppressor Receptor Protein Tyrosine Phosphatase Gamma (PTPRG) in Breast Cancer Cells

Anticancer research, 2010-06, Vol.30 (6), p.1937-1946

2010

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Osteolytic bone resorption in adult T-cell leukemia/lymphoma

Leukemia & lymphoma, 2010-04, Vol.51 (4), p.702-714

2010

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Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity

Chemistry & biology, 2013-01, Vol.20 (1), p.82-91

2013

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A Novel Bioluminescent Mouse Model and Effective Therapy for Adult T-Cell Leukemia/Lymphoma

Cancer research (Chicago, Ill.), 2007-12, Vol.67 (24), p.11859-11866

2007

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Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro

Leukemia & lymphoma, 2012-04, Vol.53 (4), p.688-698

2012

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HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

BMC chemical biology, 2012-03, Vol.12 (1), p.1-1, Article 1

2012

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Dickkopf-I (DKK-I) Stimulated Prostate Cancer Growth and Metastasis and Inhibited Bone Formation in Osteoblastic Bone Metastases

The Prostate, 2011, Vol.71 (6), p.615-625

2011

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Pathogenesis and treatments of humoral hypercalcemia of malignancy in adult T -cell leukemia /lymphoma induced by human T -lymphotropic virus type 1

Shu, Sherry T

2009

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Mechanisms of Humoral Hypercalcemia of Malignancy in Leukemia/Lymphoma

Shu, Sherry T

2011

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Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes

Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission

Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo

Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases

Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor

midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice

Characterization of bone resorption in novel in vitro and in vivo models of oral squamous cell carcinoma

HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane

PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication

Development of a brain metastatic canine prostate cancer cell line

Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation

Nef defect attenuates HIV viremia and immune dysregulation in the bone marrow-liver-thymus-spleen (BLTS) humanized mouse model

Visualization of Host Cell Kinase Activation by Viral Proteins Using GFP Fluorescence Complementation and Immunofluorescence Microscopy

Parathyroid hormone-related protein promotes bone loss in T-cell leukemia as well as in solid tumors

Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists

Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation

Function and Regulatory Mechanisms of the Candidate Tumor Suppressor Receptor Protein Tyrosine Phosphatase Gamma (PTPRG) in Breast Cancer Cells

Osteolytic bone resorption in adult T-cell leukemia/lymphoma

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity

A Novel Bioluminescent Mouse Model and Effective Therapy for Adult T-Cell Leukemia/Lymphoma

Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

Dickkopf-I (DKK-I) Stimulated Prostate Cancer Growth and Metastasis and Inhibited Bone Formation in Osteoblastic Bone Metastases

Pathogenesis and treatments of humoral hypercalcemia of malignancy in adult T -cell leukemia /lymphoma induced by human T -lymphotropic virus type 1

Mechanisms of Humoral Hypercalcemia of Malignancy in Leukemia/Lymphoma

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