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Silicon switches of marketed drugs

Mini reviews in medicinal chemistry, 2006-10, Vol.6 (10), p.1169

2006

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Chemistry challenges in lead optimization: silicon isosteres in drug discovery

Drug Discovery Today, 2003-06, Vol.8 (12), p.551-556

2003

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Sila-venlafaxine, a Sila-Analogue of the Serotonin/Noradrenaline Reuptake Inhibitor Venlafaxine: Synthesis, Crystal Structure Analysis, and Pharmacological Characterization

Organometallics, 2006-02, Vol.25 (5), p.1188-1198

2006

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Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2690-2697

1990

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4-Hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines : Selective h5-HT1D agonists for the treatment of migraine

Bioorganic & medicinal chemistry letters, 1999-12, Vol.9 (23), p.3369-3374

1999

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Tetrahydropyridyloxadiazoles : semirigid muscarinic ligands

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.1086-1094

1991

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Carbamate Oxime Reduction: A New Route to C3-Amino-1,4-benzodiazepines

Synthesis (Stuttgart), 1994, Vol.1994 (5), p.505-508

1994

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High-Affinity and Potent, Water-Soluble 5-Amino-1,4-benzodiazepine CCKB/Gastrin Receptor Antagonists Containing a Cationic Solubilizing Group

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.719-721

1994

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L-687,306 : a functionally selective and potent muscarinic M1 receptor agonist

European journal of pharmacology, 1992-04, Vol.215 (1), p.135-136

1992

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Exploitation of silicon medicinal chemistry in drug discovery

Expert opinion on investigational drugs, 2004-09, Vol.13 (9), p.1149-1157

2004

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Selective thyromimetics. Cardiac-sparing thyroid hormone analogs containing 3'-arylmethyl substituents

Journal of medicinal chemistry, 1989-02, Vol.32 (2), p.320-336

1989

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Synthesis and antihypertensive activity of 6,7-disubstituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols

Journal of medicinal chemistry, 1984-09, Vol.27 (9), p.1127-1131

1984

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2-Methyl-1,3-dioxaazaspiro[4.5]decanes as novel muscarinic cholinergic agonists

Journal of medicinal chemistry, 1988-02, Vol.31 (2), p.486-491

1988

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Approaches to rational drug development in Alzheimer's disease

Drug design and discovery, 1993, Vol.9 (3-4), p.251

1993

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Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene

Organometallics, 2005-06, Vol.24 (13), p.3192-3199

2005

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Design strategies for building drug-like chemical libraries

Current opinion in drug discovery & development, 2001-05, Vol.4 (3), p.314

2001

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( R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2555-2558

2006

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Thyroid hormone analogs. Synthesis of 3'-substituted 3,5-diiodo-L-thyronines and quantitative structure-activity studies of in vitro and in vivo thyromimetic activities in rat liver and heart

Journal of medicinal chemistry, 1988-01, Vol.31 (1), p.37-54

1988

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The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3)

Journal of peptide science, 2005-03, Vol.11 (3), p.136-141

2005

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Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor

Bioorganic & medicinal chemistry, 1998-10, Vol.6 (10), p.1731-1743

1998

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Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors

Bioorganic & medicinal chemistry, 1998-01, Vol.6 (1), p.1-8

1998

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Binding of 2,4-disubstituted morpholines at human D 4 dopamine receptors

Bioorganic & medicinal chemistry, 1998, Vol.6 (1), p.1-8

1998

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Substituted pyrazoles as novel selective ligands for the human dopamine D 4 receptor

Bioorganic & medicinal chemistry, 1998-10, Vol.6 (10), p.1731-1743

1998

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Ester bio-isosteres: synthesis of oxadiazolyl-1-azabicyclo[2.2.1]heptanes as muscarinic agonists

Journal of the Chemical Society. Chemical communications, 1988 (24), p.1618-1619

1988

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Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane

Journal of medicinal chemistry, 1992-03, Vol.35 (5), p.911-916

1992

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Silicon switches of marketed drugs

Chemistry challenges in lead optimization: silicon isosteres in drug discovery

Sila-venlafaxine, a Sila-Analogue of the Serotonin/Noradrenaline Reuptake Inhibitor Venlafaxine: Synthesis, Crystal Structure Analysis, and Pharmacological Characterization

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors

4-Hydroxy-1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidines : Selective h5-HT1D agonists for the treatment of migraine

Tetrahydropyridyloxadiazoles : semirigid muscarinic ligands

Carbamate Oxime Reduction: A New Route to C3-Amino-1,4-benzodiazepines

High-Affinity and Potent, Water-Soluble 5-Amino-1,4-benzodiazepine CCKB/Gastrin Receptor Antagonists Containing a Cationic Solubilizing Group

L-687,306 : a functionally selective and potent muscarinic M1 receptor agonist

Exploitation of silicon medicinal chemistry in drug discovery

Selective thyromimetics. Cardiac-sparing thyroid hormone analogs containing 3'-arylmethyl substituents

Synthesis and antihypertensive activity of 6,7-disubstituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols

2-Methyl-1,3-dioxaazaspiro[4.5]decanes as novel muscarinic cholinergic agonists

Approaches to rational drug development in Alzheimer's disease

Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene

Design strategies for building drug-like chemical libraries

( R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis

Thyroid hormone analogs. Synthesis of 3'-substituted 3,5-diiodo-L-thyronines and quantitative structure-activity studies of in vitro and in vivo thyromimetic activities in rat liver and heart

The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3)

Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor

Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors

Binding of 2,4-disubstituted morpholines at human D 4 dopamine receptors

Substituted pyrazoles as novel selective ligands for the human dopamine D 4 receptor

Ester bio-isosteres: synthesis of oxadiazolyl-1-azabicyclo[2.2.1]heptanes as muscarinic agonists

Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane

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