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Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies

PLoS pathogens, 2022-01, Vol.18 (1), p.e1010169

2022

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Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917

PLoS pathogens, 2022-09, Vol.18 (9), p.e1010713-e1010713

2022

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Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex

Science (American Association for the Advancement of Science), 2012-02, Vol.335 (6071), p.977-981

2012

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Bacterial cell surface characterization by phage display coupled to high-throughput sequencing

Nature communications, 2024-08, Vol.15 (1), p.7502-19, Article 7502

2024

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Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies

Scientific reports, 2023-09, Vol.13 (1), p.14632-14632, Article 14632

2023

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Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies

PloS one, 2023-11, Vol.18 (11), p.e0291937-e0291937

2023

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Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin

Nature communications, 2017-09, Vol.8 (1), p.423-13, Article 423

2017

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Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Nature communications, 2023-04, Vol.14 (1), p.2338-14, Article 2338

2023

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The Degradation of Botulinum Neurotoxin Light Chains Using PROTACs

International journal of molecular sciences, 2024-07, Vol.25 (13), p.7472

2024

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A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2

Infection and Immunity, 2013-12, Vol.81 (12), p.4592-4603

2013

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Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

Scientific reports, 2022-07, Vol.12 (1), p.11664-11664, Article 11664

2022

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Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins

Cell reports (Cambridge), 2020-02, Vol.30 (8), p.2526-2539.e6

2020

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Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host

PLoS pathogens, 2010-06, Vol.6 (6), p.e1000932-e1000932

2010

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Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins

PLoS neglected tropical diseases, 2017-01, Vol.11 (1), p.e0005306-e0005306

2017

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Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells

Toxins, 2020-09, Vol.12 (10), p.616

2020

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Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein

PloS one, 2014-08, Vol.9 (8), p.e106422

2014

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A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model

PloS one, 2012-01, Vol.7 (1), p.e29941

2012

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Accelerated neuronal cell recovery from Botulinum neurotoxin intoxication by targeted ubiquitination

PloS one, 2011-05, Vol.6 (5), p.e20352

2011

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Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (38), p.16554-16559

2010

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A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding

Scientific reports, 2017-08, Vol.7 (1), p.7438-12, Article 7438

2017

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Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm

Protein engineering, design and selection, 2010-06, Vol.23 (6), p.489-498

2010

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Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

Toxins, 2020-09, Vol.12 (10), p.611

2020

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Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism

Science translational medicine, 2021-01, Vol.13 (575)

2021

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Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB)

PloS one, 2014-06, Vol.9 (6), p.e99788

2014

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Anti-schistosomal immunity to core xylose/fucose in N-glycans

Frontiers in molecular biosciences, 2023-04, Vol.10, p.1142620-1142620

2023

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Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917

Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex

Bacterial cell surface characterization by phage display coupled to high-throughput sequencing

Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies

Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies

Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

The Degradation of Botulinum Neurotoxin Light Chains Using PROTACs

A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2

Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins

Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host

Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins

Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells

Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein

A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model

Accelerated neuronal cell recovery from Botulinum neurotoxin intoxication by targeted ubiquitination

Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding

Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism

Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB)

Anti-schistosomal immunity to core xylose/fucose in N-glycans

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