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Observing a DNA Polymerase Choose Right from Wrong

Cell, 2013-07, Vol.154 (1), p.157-168

2013

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Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Nature (London), 2015-01, Vol.517 (7536), p.635-639

2015

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Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints

Nature communications, 2022-06, Vol.13 (1), p.3193-12, Article 3193

2022

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Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

The Journal of biological chemistry, 2010-12, Vol.285 (52), p.40479-40488

2010

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Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

Nature communications, 2017-08, Vol.8 (1), p.253-11, Article 253

2017

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Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Nature communications, 2021-08, Vol.12 (1), p.5055-11, Article 5055

2021

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Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

Nature communications, 2021-04, Vol.12 (1), p.2059-12, Article 2059

2021

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A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

Nucleic acids research, 2019-04, Vol.47 (6), p.3197

2019

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Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

Structure (London), 2006-04, Vol.14 (4), p.757-766

2006

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Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (1), p.113-118

2012

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Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate

ACS omega, 2020-06, Vol.5 (25), p.15317-15324

2020

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Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity

The Journal of biological chemistry, 2002-12, Vol.277 (49), p.47393-47398

2002

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Steady-state, pre-steady-state, and single-turnover kinetic measurement for DNA glycosylase activity

Journal of visualized experiments, 2013-08 (78), p.e50695

2013

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Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15693-15698

2010

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Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

Nature chemical biology, 2017-10, Vol.13 (10), p.1074

2017

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Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β

The Journal of biological chemistry, 2019-05, Vol.294 (18), p.7194-7201

2019

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DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

The Journal of biological chemistry, 2020-01, Vol.295 (2), p.529-538

2020

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Substrate-induced DNA Polymerase β Activation

The Journal of biological chemistry, 2014-11, Vol.289 (45), p.31411-31422

2014

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Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

Molecular cell, 2008-05, Vol.30 (3), p.315-324

2008

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Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

Journal of the American Chemical Society, 2013-05, Vol.135 (21), p.8078-8088

2013

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Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/Apyrimidinic Endonuclease 1 and DNA Polymerase β

The Journal of biological chemistry, 2007-05, Vol.282 (18), p.13532-13541

2007

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Structure of DNA Polymerase β with a Benzo[c]phenanthrene Diol Epoxide-Adducted Template Exhibits Mutagenic Features

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17231-17236

2006

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DNA Polymerase λ Mediates a Back-up Base Excision Repair Activity in Extracts of Mouse Embryonic Fibroblasts

The Journal of biological chemistry, 2005-05, Vol.280 (18), p.18469-18475

2005

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Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation

Biochemistry (Easton), 2014-04, Vol.53 (14), p.2413-2422

2014

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DNA Polymerase β and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair

The Journal of biological chemistry, 2005-02, Vol.280 (5), p.3665-3674

2005

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Observing a DNA Polymerase Choose Right from Wrong

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints

Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion

Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate

Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity

Steady-state, pre-steady-state, and single-turnover kinetic measurement for DNA glycosylase activity

Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β

DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

Substrate-induced DNA Polymerase β Activation

Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/Apyrimidinic Endonuclease 1 and DNA Polymerase β

Structure of DNA Polymerase β with a Benzo[c]phenanthrene Diol Epoxide-Adducted Template Exhibits Mutagenic Features

DNA Polymerase λ Mediates a Back-up Base Excision Repair Activity in Extracts of Mouse Embryonic Fibroblasts

Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation

DNA Polymerase β and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair

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