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Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

Nature medicine, 2022-01, Vol.28 (1), p.104-116

2022

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FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

Nature communications, 2017-03, Vol.8 (1), p.14741-11, Article 14741

2017

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Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

Neuron (Cambridge, Mass.), 2014-12, Vol.84 (6), p.1213-1225

2014

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ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

Nature communications, 2016-02, Vol.7 (1), p.10465-14, Article 10465

2016

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Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS

Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (51), p.E8316-E8325

2016

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Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS

Cell reports (Cambridge), 2019-01, Vol.26 (2), p.364-373.e4

2019

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The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

eLife, 2016-09, Vol.5

2016

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FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA

Cell reports (Cambridge), 2012-10, Vol.2 (4), p.799-806

2012

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The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span

The Journal of clinical investigation, 2011-10, Vol.121 (10), p.4118-4126

2011

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Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

eLife, 2018-03, Vol.7

2018

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Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging

Nature communications, 2016-10, Vol.7 (1), p.13283-13283, Article 13283

2016

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A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons

Molecular neurobiology, 2018-10, Vol.55 (10), p.7635-7651

2018

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A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS

Genome research, 2019-05, Vol.29 (5), p.809-818

2019

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Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

eLife, 2018-07, Vol.7

2018

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Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells

Journal of comparative neurology (1911), 2016-06, Vol.524 (9), p.1892-1919

2016

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Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS

Stem cell research, 2018-03, Vol.27, p.172-179

2018

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Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival

Neural development, 2009-12, Vol.4 (1), p.42-42

2009

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ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

Genes & development, 2020-06, Vol.34 (11-12), p.785-805

2020

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Stasimon/Tmem41b is required for cell proliferation and adult mouse survival

Biochemical and biophysical research communications, 2024-06, Vol.712-713, p.149923, Article 149923

2024

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Science (American Association for the Advancement of Science), 2015-03, Vol.347 (6229), p.1436-1441

2015

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Standardized Reporter Systems for Purification and Imaging of Human Pluripotent Stem Cell-derived Motor Neurons and Other Cholinergic Cells

Neuroscience, 2020-12, Vol.450, p.48-56

2020

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Formation of RNA G-wires by G4C2 repeats associated with ALS and FTD

Biochemical and biophysical research communications, 2022-06, Vol.610, p.113-118

2022

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Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4

Nature (London), 2022-06, Vol.606 (7916), p.945-952

2022

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Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target

Genetics (Austin), 2020-07, Vol.215 (3), p.747-766

2020

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Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS

Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA

The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span

Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging

A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons

A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells

Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS

Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival

ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

Stasimon/Tmem41b is required for cell proliferation and adult mouse survival

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Standardized Reporter Systems for Purification and Imaging of Human Pluripotent Stem Cell-derived Motor Neurons and Other Cholinergic Cells

Formation of RNA G-wires by G4C2 repeats associated with ALS and FTD

Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4

Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target

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