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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects

The Journal of pharmacology and experimental therapeutics, 2015-03, Vol.352 (3), p.590

2015

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Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

Frontiers in neuroscience, 2014-02, Vol.8, p.28-28

2014

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Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

Translational psychiatry, 2020-09, Vol.10 (1), p.308-308, Article 308

2020

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Direct Catalytic Asymmetric Aldol Additions of Methyl Ynones. Spontaneous Reversal in the Sense of Enantioinduction

Journal of the American Chemical Society, 2004-03, Vol.126 (9), p.2660-2661

2004

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Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

Frontiers in behavioral neuroscience, 2017-05, Vol.11, p.83-83

2017

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Copper-mediated synthesis of drug-like bicyclopentanes

Nature (London), 2020-04, Vol.580 (7802), p.220-226

2020

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Dinuclear Asymmetric Zn Aldol Additions: Formal Asymmetric Synthesis of Fostriecin

Journal of the American Chemical Society, 2005-03, Vol.127 (11), p.3666-3667

2005

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Selective orexin receptor antagonists

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.4761-4769

2013

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Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D)

Bioorganic & medicinal chemistry letters, 2023-11, Vol.96, p.129492-129492, Article 129492

2023

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Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions

ACS medicinal chemistry letters, 2024-04, Vol.15 (4), p.486-492

2024

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Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate

Journal of medicinal chemistry, 2015-07, Vol.58 (14), p.5620-5636

2015

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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793

ACS medicinal chemistry letters, 2020-10, Vol.11 (10), p.2002-2009

2020

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Substituted 5,6-(Dihydropyrido[3,4‑d]pyrimidin-7(8H)‑yl)-methanones as P2X7 Antagonists

ACS chemical neuroscience, 2016-04, Vol.7 (4), p.498-504

2016

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Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex

Frontiers in neuroscience, 2014-05, Vol.8, p.107-107

2014

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A Practical Synthesis of Regioisomeric 6- and 7-Methoxytetrahydro-3-benzazepines

Organic process research & development, 2010-03, Vol.14 (2), p.380-385

2010

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2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists

Bioorganic & medicinal chemistry letters, 2008-03, Vol.18 (6), p.2103-2108

2008

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Rapid syntheses of either enantiomer of important carbocyclic nucleoside precursors

Tetrahedron letters, 2000-12, Vol.41 (49), p.9537-9540

2000

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Synthesis of Enantiomerically and Diastereomerically Pure 2(S)-Amino-6(R)-hydroxy-1,7-heptanedioic Acid Dimethyl Ester Hydrochloride from Cycloheptadiene

Journal of organic chemistry, 2001-07, Vol.66 (14), p.4809-4813

2001

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Conformational Study and Enantioselective, Regiospecific Syntheses of Novel Aminoxy trans-Proline Analogues Derived from an Acylnitroso Diels−Alder Cycloaddition

Journal of organic chemistry, 2001-09, Vol.66 (18), p.6046-6056

2001

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Identification of small-molecule protein-protein interaction inhibitors for NKG2D

Proceedings of the National Academy of Sciences - PNAS, 2023-05, Vol.120 (18), p.e2216342120-e2216342120

2023

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ChemInform Abstract: Selective Orexin Receptor Antagonists

ChemInform, 2013-10, Vol.44 (42), p.no-no

2013

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Corrigendum to “2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists” [Bioorg. Med. Chem. Lett. 18 (2008) 2103–2108]

Bioorganic & medicinal chemistry letters, 2008-07, Vol.18 (14), p.4253

2008

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2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT 2A antagonists

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (6), p.2103-2108

2008

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Corrigendum to “2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT 2A antagonists” [Bioorg. Med. Chem. Lett. 18 (2008) 2103–2108]

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (14), p.4253-4253

2008

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DIC-Mediated Coupling of Carboxylic Acids to (4R, 5S)-4-Methyl-5-Phenyl-2-Oxazolidinone

Synthetic communications, 2000-04, Vol.30 (7), p.1221-1226

2000

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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

Direct Catalytic Asymmetric Aldol Additions of Methyl Ynones. Spontaneous Reversal in the Sense of Enantioinduction

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

Copper-mediated synthesis of drug-like bicyclopentanes

Dinuclear Asymmetric Zn Aldol Additions: Formal Asymmetric Synthesis of Fostriecin

Selective orexin receptor antagonists

Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D)

Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions

Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate

Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793

Substituted 5,6-(Dihydropyrido[3,4‑d]pyrimidin-7(8H)‑yl)-methanones as P2X7 Antagonists

Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex

A Practical Synthesis of Regioisomeric 6- and 7-Methoxytetrahydro-3-benzazepines

2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists

Rapid syntheses of either enantiomer of important carbocyclic nucleoside precursors

Synthesis of Enantiomerically and Diastereomerically Pure 2(S)-Amino-6(R)-hydroxy-1,7-heptanedioic Acid Dimethyl Ester Hydrochloride from Cycloheptadiene

Conformational Study and Enantioselective, Regiospecific Syntheses of Novel Aminoxy trans-Proline Analogues Derived from an Acylnitroso Diels−Alder Cycloaddition

Identification of small-molecule protein-protein interaction inhibitors for NKG2D

ChemInform Abstract: Selective Orexin Receptor Antagonists

Corrigendum to “2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists” [Bioorg. Med. Chem. Lett. 18 (2008) 2103–2108]

2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT 2A antagonists

Corrigendum to “2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT 2A antagonists” [Bioorg. Med. Chem. Lett. 18 (2008) 2103–2108]

DIC-Mediated Coupling of Carboxylic Acids to (4R, 5S)-4-Methyl-5-Phenyl-2-Oxazolidinone

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