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Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity

Journal of lipid research, 2011-04, Vol.52 (4), p.646-656

2011

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Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase

Journal of medicinal chemistry, 2014-11, Vol.57 (21), p.8817-8826

2014

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Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (9), p.2590-2594

2013

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Substituted piperidines as HDM2 inhibitors

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (4), p.1026-1030

2014

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MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.761-767

2018

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Discovery of novel imidazo[1,2- a]pyrazin-8-amines as Brk/PTK6 inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5870-5875

2011

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Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1)

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.791-796

2013

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Structure–activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53–hDM2 inhibitors

Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (11), p.2735-2738

2016

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Discovery and optimization of antibacterial AccC inhibitors

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6507-6514

2009

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Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (8), p.1983-1986

2014

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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain

Biochemistry (Easton), 2010-09, Vol.49 (38), p.8350-8358

2010

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Application of affinity selection-mass spectrometry assays to purification and affinity-based screening of the chemokine receptor CXCR4

Combinatorial chemistry & high throughput screening, 2012-07, Vol.15 (6), p.473

2012

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Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.199-203

2014

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Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode

ACS medicinal chemistry letters, 2012-02, Vol.3 (2), p.123-128

2012

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Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3405-3409

2009

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Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.324-329

2016

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Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

ACS medicinal chemistry letters, 2014-05, Vol.5 (5), p.572-575

2014

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Inhibitors of the lipid phosphatase SHIP2 discovered by high-throughput affinity selection-mass spectrometry screening of combinatorial libraries

Combinatorial chemistry & high throughput screening, 2009-09, Vol.12 (8), p.760

2009

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Pyrazolo[1,5- a]pyrimidine-based inhibitors of HCV polymerase

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6331-6336

2009

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Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro- N-(( S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2119-2124

2010

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Method for Quantitative Protein−Ligand Affinity Measurements in Compound Mixtures

Analytical chemistry (Washington), 2007-06, Vol.79 (12), p.4538-4542

2007

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Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

ACS chemical biology, 2011-06, Vol.6 (6), p.636-647

2011

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Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors

ACS medicinal chemistry letters, 2011-08, Vol.2 (8), p.632-637

2011

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Direct synthesis of Cbz-protected (2-amino)-6-(2-aminoethyl)pyridines

Tetrahedron, 2010-03, Vol.66 (11), p.1973-1979

2010

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Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5363-5367

2009

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Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity

Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase

Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors

Substituted piperidines as HDM2 inhibitors

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology

Discovery of novel imidazo[1,2- a]pyrazin-8-amines as Brk/PTK6 inhibitors

Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1)

Structure–activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53–hDM2 inhibitors

Discovery and optimization of antibacterial AccC inhibitors

Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction

Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain

Application of affinity selection-mass spectrometry assays to purification and affinity-based screening of the chemokine receptor CXCR4

Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor

Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode

Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors

Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

Inhibitors of the lipid phosphatase SHIP2 discovered by high-throughput affinity selection-mass spectrometry screening of combinatorial libraries

Pyrazolo[1,5- a]pyrimidine-based inhibitors of HCV polymerase

Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro- N-(( S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides

Method for Quantitative Protein−Ligand Affinity Measurements in Compound Mixtures

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors

Direct synthesis of Cbz-protected (2-amino)-6-(2-aminoethyl)pyridines

Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase

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