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Emerging strategies for cancer therapy by ATR inhibitors

Cancer science, 2023-07, Vol.114 (7), p.2709-2721

2023

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Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Molecular cell, 2009-03, Vol.33 (5), p.547-558

2009

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Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

Cell, 2018-10, Vol.175 (2), p.558-570.e11

2018

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ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

Molecular cell, 2011-07, Vol.43 (2), p.192-202

2011

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An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress

Nature communications, 2023-08, Vol.14 (1), p.4991-4991, Article 4991

2023

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Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

Cell reports (Cambridge), 2013-05, Vol.3 (5), p.1651-1662

2013

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The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response

Molecular cell, 2010-07, Vol.39 (2), p.259-268

2010

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Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor

Carcinogenesis (New York), 2013-11, Vol.34 (11), p.2486-2497

2013

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Chk1 and Claspin potentiate PCNA ubiquitination

Genes & development, 2008-05, Vol.22 (9), p.1147-1152

2008

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Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (8), p.2760-2765

2012

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DSE‐FRET: A new anticancer drug screening assay for DNA binding proteins

Cancer science, 2014-07, Vol.105 (7), p.870-874

2014

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Frequent amplification of receptor tyrosine kinase genes in well-differentiated/ dedifferentiated liposarcoma

Oncotarget, 2017-02, Vol.8 (8), p.12941-12952

2017

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CBP-93872 Inhibits NBS1-Mediated ATR Activation, Abrogating Maintenance of the DNA Double-Strand Break-Specific G2 Checkpoint

Cancer research (Chicago, Ill.), 2014-07, Vol.74 (14), p.3880-3889

2014

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A human cell extract-based assay for the activation of ATM and ATR checkpoint kinases

Methods in molecular biology (Clifton, N.J.), 2011-01, Vol.782, p.181

2011

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UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation

Molecular and cellular biology, 2016-02, Vol.36 (3), p.394-406

2016

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ATR signaling at a glance

Journal of cell science, 2009-02, Vol.122 (3), p.301-304

2009

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Tolerance of Oncogene-Induced Replication Stress: A Fuel for Genomic Instability

Cancers, 2024-10, Vol.16 (20), p.3507

2024

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p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis

Biochimica et biophysica acta. Molecular cell research, 2023-08, Vol.1870 (6), p.119484-119484, Article 119484

2023

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PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA

The Journal of biological chemistry, 2021-07, Vol.297 (1), p.100882-100882, Article 100882

2021

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Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor

Carcinogenesis (New York), 2013-11, Vol.34 (11), p.2486-2497

2013

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Involvement of the ATR- and ATM-Dependent Checkpoint Responses in Cell Cycle Arrest Evoked by Pierisin-1

Molecular cancer research, 2006-02, Vol.4 (2), p.125-133

2006

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Involvement of nucleotide excision repair (NER) system in repair of mono ADP-ribosylated dG adducts produced by pierisin-1, a cytotoxic protein from cabbage butterfly

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2005-05, Vol.572 (1), p.150-155

2005

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Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma

Oncotarget, 2017-02, Vol.8 (8), p.12941-12952

2017

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SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

NAR cancer, 2020-06, Vol.2 (2)

2020

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Developmental stage-specific expression and tissue distribution of pierisin-1, a guanine-specific ADP-ribosylating toxin, in Pieris rapae

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2004-10, Vol.139 (2), p.125-131

2004

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Emerging strategies for cancer therapy by ATR inhibitors

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress

Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response

Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor

Chk1 and Claspin potentiate PCNA ubiquitination

Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses

DSE‐FRET: A new anticancer drug screening assay for DNA binding proteins

Frequent amplification of receptor tyrosine kinase genes in well-differentiated/ dedifferentiated liposarcoma

CBP-93872 Inhibits NBS1-Mediated ATR Activation, Abrogating Maintenance of the DNA Double-Strand Break-Specific G2 Checkpoint

A human cell extract-based assay for the activation of ATM and ATR checkpoint kinases

UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation

ATR signaling at a glance

Tolerance of Oncogene-Induced Replication Stress: A Fuel for Genomic Instability

p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis

PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA

Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor

Involvement of the ATR- and ATM-Dependent Checkpoint Responses in Cell Cycle Arrest Evoked by Pierisin-1

Involvement of nucleotide excision repair (NER) system in repair of mono ADP-ribosylated dG adducts produced by pierisin-1, a cytotoxic protein from cabbage butterfly

Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma

SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

Developmental stage-specific expression and tissue distribution of pierisin-1, a guanine-specific ADP-ribosylating toxin, in Pieris rapae

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