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Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

Journal of industrial microbiology & biotechnology, 2014-02, Vol.41 (2), p.233-250

2014

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Reconstitution of a Type II Polyketide Synthase that Catalyzes Polyene Formation

Angewandte Chemie International Edition, 2018-02, Vol.57 (7), p.1954-1957

International ed. in English, 2018

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Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis

Angewandte Chemie International Edition, 2023-07, Vol.62 (29), p.e202305155-n/a

International ed. in English, 2023

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Bacterial Avenalumic Acid Biosynthesis Includes Substitution of an Aromatic Amino Group for Hydride by Nitrous Acid Dependent Diazotization

Angewandte Chemie International Edition, 2022-11, Vol.61 (45), p.e202211728-n/a

International ed. in English, 2022

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Identification of the Cirratiomycin Biosynthesis Gene Cluster in Streptomyces Cirratus: Elucidation of the Biosynthetic Pathways for 2,3‐Diaminobutyric Acid and Hydroxymethylserine

Chemistry : a European journal, 2024-05, Vol.30 (28), p.e202400271-n/a

2024

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In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq‐Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont

Angewandte Chemie International Edition, 2024-03, Vol.63 (10), p.e202317805-n/a

International ed. in English, 2024

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Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics

Journal of antibiotics, 2021-10, Vol.74 (10), p.617-628

2021

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FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

Molecular and Cellular Biology, 2008-06, Vol.28 (12), p.4116-4128

2008

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Structural and Functional Analyses of the Tridomain‐Nonribosomal Peptide Synthetase FmoA3 for 4‐Methyloxazoline Ring Formation

Angewandte Chemie International Edition, 2021-06, Vol.60 (26), p.14554-14562

International ed. in English, 2021

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Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

Nature communications, 2020-09, Vol.11 (1), p.4660-4660, Article 4660

2020

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Acyltransferase Domain Exchange between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics

Chembiochem : a European journal of chemical biology, 2023-03, Vol.24 (6), p.e202200670-n/a

2023

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Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6‐Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6‐Methyltransferase

Angewandte Chemie International Edition, 2022-01, Vol.61 (1), p.e202111217-n/a

International ed. in English, 2022

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An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces

Angewandte Chemie International Edition, 2019-09, Vol.58 (38), p.13349-13353

International ed. in English, 2019

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Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma

Cancer science, 2021-03, Vol.112 (3), p.1225-1234

2021

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Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi

Angewandte Chemie International Edition, 2016-07, Vol.55 (28), p.8072-8075

International ed. in English, 2016

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Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

The EMBO journal, 2013-05, Vol.32 (10), p.1425-1439

2013

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Neothioviridamide, a Polythioamide Compound Produced by Heterologous Expression of a Streptomyces sp. Cryptic RiPP Biosynthetic Gene Cluster

Journal of natural products (Washington, D.C.), 2018-02, Vol.81 (2), p.264-269

2018

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In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

Nature communications, 2020-08, Vol.11 (1), p.4022-4022, Article 4022

2020

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Terpene synthases are widely distributed in bacteria

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (3), p.857-862

2015

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Structural Basis for the Prenylation Reaction of Carbazole‐Containing Natural Products Catalyzed by Squalene Synthase‐Like Enzymes

Angewandte Chemie International Edition, 2022-05, Vol.61 (20), p.e202117430-n/a

International ed. in English, 2022

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An Atypical Arginine Dihydrolase Involved in the Biosynthesis of Cyclic Hexapeptide Longicatenamides

Chemistry, an Asian journal, 2021-06, Vol.16 (11), p.1382-1387

2021

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Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908

Journal of antibiotics, 2020-03, Vol.73 (3), p.171-174

2020

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Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin

Journal of antibiotics, 2020-09, Vol.73 (9), p.650-654

2020

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Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08

Chembiochem : a European journal of chemical biology, 2016-08, Vol.17 (15), p.1464-1471

2016

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A novel oxazole-containing tetraene compound, JBIR-159, produced by heterologous expression of the cryptic trans-AT type polyketide synthase biosynthetic gene cluster

Journal of antibiotics, 2021-05, Vol.74 (5), p.354-358

2021

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Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

Reconstitution of a Type II Polyketide Synthase that Catalyzes Polyene Formation

Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis

Bacterial Avenalumic Acid Biosynthesis Includes Substitution of an Aromatic Amino Group for Hydride by Nitrous Acid Dependent Diazotization

Identification of the Cirratiomycin Biosynthesis Gene Cluster in Streptomyces Cirratus: Elucidation of the Biosynthetic Pathways for 2,3‐Diaminobutyric Acid and Hydroxymethylserine

In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq‐Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont

Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

Structural and Functional Analyses of the Tridomain‐Nonribosomal Peptide Synthetase FmoA3 for 4‐Methyloxazoline Ring Formation

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

Acyltransferase Domain Exchange between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics

Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6‐Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6‐Methyltransferase

An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces

Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma

Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

Neothioviridamide, a Polythioamide Compound Produced by Heterologous Expression of a Streptomyces sp. Cryptic RiPP Biosynthetic Gene Cluster

In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

Terpene synthases are widely distributed in bacteria

Structural Basis for the Prenylation Reaction of Carbazole‐Containing Natural Products Catalyzed by Squalene Synthase‐Like Enzymes

An Atypical Arginine Dihydrolase Involved in the Biosynthesis of Cyclic Hexapeptide Longicatenamides

Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908

Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin

Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08

A novel oxazole-containing tetraene compound, JBIR-159, produced by heterologous expression of the cryptic trans-AT type polyketide synthase biosynthetic gene cluster

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