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New Antitumor Substances, FR901463, FR901464 and FR901465: II. Activities against Experimental Tumors in Mice and Mechanism of Action

The Journal of Antibiotics, 1996/12/25, Vol.49(12), pp.1204-1211

1996

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FR901228, A NOVEL ANTITUMOR BICYCLIC DEPSIPEPTIDE PRODUCED BY Chromobacterium violaceum No. 968: III. ANTITUMOR ACTIVITIES ON EXPERIMENTAL TUMORS IN MICE

The Journal of Antibiotics, 1994/03/25, Vol.47(3), pp.315-323

1994

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Combined blockade of 5-HT3- and 5-HT4-serotonin receptors inhibits colonic functions in conscious rats and mice

The Journal of pharmacology and experimental therapeutics, 1997-04, Vol.281 (1), p.284

1997

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Difference between Normal and WHHL Rabbits in Susceptibility to the Adrenal Toxicity of an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, FR145237

Toxicology and applied pharmacology, 1996-10, Vol.140 (2), p.387-392

1996

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Anti‐cachectic Effect of FK317, a Novel Anti‐cancer Agent, in Colon26 and LX‐1 Models in Mice

Cancer science, 1998-12, Vol.89 (12), p.1318-1325

1998

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FK317, a Novel Substituted Dihydrobenzoxazine, Exhibits Potent Antitumor Activity against Human Tumor Xenografts in Nude Mice

Cancer science, 1998-12, Vol.89 (12), p.1306-1317

1998

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Different Effects of FK317 on Multidrug‐resistant Tumor in vivo and in vitro

Cancer science, 1998-10, Vol.89 (10), p.1047-1054

1998

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Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall

Biochimica et biophysica acta, 1995-12, Vol.1259 (3), p.254-260

1995

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Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-L-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain

Applied and Environmental Microbiology, 1997-02, Vol.63 (2), p.454-460

1997

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Immunosuppressive activity of a microbial product

Folia Pharmacologica Japonica, 1997, Vol.110(supplement), pp.69-74

1997

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High‐level Production, Chemical Modification and Site‐directed Mutagenesis of a Cephalosporin C Acylase from Pseudomonas Strain N176

European journal of biochemistry, 1995-06, Vol.230 (2), p.773-778

1995

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Cholesterol-lowering effect of an acyl-coenzyme A: Cholesterol acyltransferase inhibitor, FR145237, in hypercholesterolemic rabbits fed a high-cholesterol diet and a cholesterol-free casein diet

Drug development research, 1995-12, Vol.36 (4), p.186-192

1995

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A NEW ANTITUMOR ANTIBIOTIC, FR-900482: IV. HEMATOLOGICAL TOXICITY IN MICE

The Journal of Antibiotics, 1987/05/25, Vol.40(5), pp.607-611

1987

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A NEW ANTITUMOR ANTIBIOTIC, FR-900482: V. INTERSTRAND DNA-DNA CROSS-LINKS IN L1210 CELLS

The Journal of Antibiotics, 1988/10/25, Vol.41(10), pp.1497-1499

1988

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A New Aromatase Inhibitor, FR901537: II. Pharmacological and Antitumor Effects

The Journal of Antibiotics, 1995/08/25, Vol.48(8), pp.763-767

1995

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The Induction of Interleukin-6 (IL-6) and Colony-Stimulating Factors (CSFs) by FK565 and Its Thrombopoietic Activity Following in Vivo Administration

Biological and Pharmaceutical Bulletin, 1994/02/15, Vol.17(2), pp.173-179

1994

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Bromine Residue at Hydrophilic Region Influences Biological Activity of Aplysiatoxin, a Tumor Promoter

Science (American Association for the Advancement of Science), 1983-12, Vol.222 (4629), p.1242-1244

1983

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Recombinant insulin-like growth factor I normalizes expression of renal glucose transporters in diabetic rats

American journal of physiology. Renal physiology, 1997-07, Vol.273 (1), p.27-F37

1997

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A NEW ANTITUMOR ANTIBIOTIC, FR900840: III. ANTITUMOR ACTIVITY AGAINST EXPERIMENTAL TUMORS

The Journal of Antibiotics, 1989/04/25, Vol.42(4), pp.553-557

1989

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FK317 : a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome

Cancer chemotherapy and pharmacology, 1998, Vol.42 (1), p.31-36

1998

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Effects of a novel orally-active antiallergic drug, quinotolast (FK021), on airway clearance

Folia Pharmacologica Japonica, 1994, Vol.104(4), pp.347-355

1994

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Specific Metabolic Activation of FK973, a New Antitumor Antibiotic, in L1210 Leukemia Cells

The Japanese Journal of Pharmacology, 1990, Vol.53(4), pp.463-472

1990

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Analgesic Effect of Morphine Glucuronides

The Tohoku Journal of Experimental Medicine, 1971, Vol.105(1), pp.45-52

1971

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Implication of Sensory Neurons in the Diverse Mechanisms of Adaptive Cytoprotection in the Rat Stomach

The Japanese Journal of Pharmacology, 1996, Vol.70(4), pp.347-350

1996

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Cytotoxic Mechanisms of FK317, a New Class of Bioreductive Agent with Potent Antitumor Activity

Cancer science, 1998-06, Vol.89 (6), p.666-672

1998

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New Antitumor Substances, FR901463, FR901464 and FR901465: II. Activities against Experimental Tumors in Mice and Mechanism of Action

FR901228, A NOVEL ANTITUMOR BICYCLIC DEPSIPEPTIDE PRODUCED BY Chromobacterium violaceum No. 968: III. ANTITUMOR ACTIVITIES ON EXPERIMENTAL TUMORS IN MICE

Combined blockade of 5-HT3- and 5-HT4-serotonin receptors inhibits colonic functions in conscious rats and mice

Difference between Normal and WHHL Rabbits in Susceptibility to the Adrenal Toxicity of an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, FR145237

Anti‐cachectic Effect of FK317, a Novel Anti‐cancer Agent, in Colon26 and LX‐1 Models in Mice

FK317, a Novel Substituted Dihydrobenzoxazine, Exhibits Potent Antitumor Activity against Human Tumor Xenografts in Nude Mice

Different Effects of FK317 on Multidrug‐resistant Tumor in vivo and in vitro

Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall

Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-L-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain

Immunosuppressive activity of a microbial product

High‐level Production, Chemical Modification and Site‐directed Mutagenesis of a Cephalosporin C Acylase from Pseudomonas Strain N176

Cholesterol-lowering effect of an acyl-coenzyme A: Cholesterol acyltransferase inhibitor, FR145237, in hypercholesterolemic rabbits fed a high-cholesterol diet and a cholesterol-free casein diet

A NEW ANTITUMOR ANTIBIOTIC, FR-900482: IV. HEMATOLOGICAL TOXICITY IN MICE

A NEW ANTITUMOR ANTIBIOTIC, FR-900482: V. INTERSTRAND DNA-DNA CROSS-LINKS IN L1210 CELLS

A New Aromatase Inhibitor, FR901537: II. Pharmacological and Antitumor Effects

The Induction of Interleukin-6 (IL-6) and Colony-Stimulating Factors (CSFs) by FK565 and Its Thrombopoietic Activity Following in Vivo Administration

Bromine Residue at Hydrophilic Region Influences Biological Activity of Aplysiatoxin, a Tumor Promoter

Recombinant insulin-like growth factor I normalizes expression of renal glucose transporters in diabetic rats

A NEW ANTITUMOR ANTIBIOTIC, FR900840: III. ANTITUMOR ACTIVITY AGAINST EXPERIMENTAL TUMORS

FK317 : a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome

Effects of a novel orally-active antiallergic drug, quinotolast (FK021), on airway clearance

Specific Metabolic Activation of FK973, a New Antitumor Antibiotic, in L1210 Leukemia Cells

Analgesic Effect of Morphine Glucuronides

Implication of Sensory Neurons in the Diverse Mechanisms of Adaptive Cytoprotection in the Rat Stomach

Cytotoxic Mechanisms of FK317, a New Class of Bioreductive Agent with Potent Antitumor Activity

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