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Gene Amplification and the Extrachromosomal Circular DNA

Genes, 2021-09, Vol.12 (10), p.1533

Shimizu, Noriaki

2021

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Repeat induces not only gene silencing, but also gene activation in mammalian cells

PloS one, 2020-06, Vol.15 (6), p.e0235127-e0235127

2020

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Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells

Scientific reports, 2017-08, Vol.7 (1), p.8097-12, Article 8097

2017

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Epigenetic Repeat-Induced Gene Silencing in the Chromosomal and Extrachromosomal Contexts in Human Cells

PloS one, 2016-08, Vol.11 (8), p.e0161288-e0161288

2016

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Targeted amplification of a sequence of interest in artificial chromosome in mammalian cells

Nucleic acids research, 2019-06, Vol.47 (11), p.5998-6006

2019

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Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures

Scientific reports, 2023-07, Vol.13 (1), p.11765-11765, Article 11765

2023

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Emergence of micronuclei and their effects on the fate of cells under replication stress

PloS one, 2010-04, Vol.5 (4), p.e10089

2010

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SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing

The Journal of biological chemistry, 2021-01, Vol.296, p.100356-100356, Article 100356

2021

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Dissection of the beta-globin replication-initiation region reveals specific requirements for replicator elements during gene amplification

PloS one, 2013-10, Vol.8 (10), p.e77350

2013

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Amplification of a transgene within a long array of replication origins favors higher gene expression in animal cells

PloS one, 2017-04, Vol.12 (4), p.e0175585-e0175585

2017

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LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation

Nucleic acids research, 2018-06, Vol.46 (11), p.5441-5454

2018

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An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells

Scientific reports, 2019-11, Vol.9 (1), p.16954-13, Article 16954

2019

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Efficient recombinant production in mammalian cells using a novel IR/MAR gene amplification method

PloS one, 2012-07, Vol.7 (7), p.e41787-e41787

2012

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Generation of micronuclei during interphase by coupling between cytoplasmic membrane blebbing and nuclear budding

PloS one, 2011-11, Vol.6 (11), p.e27233-e27233

2011

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Fusion of the Dhfr/Mtx and IR/MAR gene amplification methods produces a rapid and efficient method for stable recombinant protein production

PloS one, 2012-12, Vol.7 (12), p.e52990

2012

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Double‐strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation

Genes chromosomes & cancer, 2020-03, Vol.59 (3), p.133-143

2020

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Cloning and Characterization of a Human Genomic Sequence that Alleviates Repeat-Induced Gene Silencing

PloS one, 2016-04, Vol.11 (4), p.e0153338-e0153338

2016

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The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

Scientific reports, 2017-01, Vol.7 (1), p.39752, Article 39752

2017

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Pressure overload inhibits glucocorticoid receptor transcriptional activity in cardiomyocytes and promotes pathological cardiac hypertrophy

Journal of molecular and cellular cardiology, 2019-05, Vol.130, p.122-130

2019

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How a replication origin and matrix attachment region accelerate gene amplification under replication stress in mammalian cells

PloS one, 2014-07, Vol.9 (7), p.e103439

2014

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Amplification of a plasmid bearing a mammalian replication initiation region in chromosomal and extrachromosomal contexts

Nucleic acids research, 2011-02, Vol.39 (3), p.958-969

2011

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Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice

Biochemical and biophysical research communications, 2014-10, Vol.453 (3), p.600-605

2014

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Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis

The Journal of clinical investigation, 2009-06, Vol.119 (6), p.1477-1488

2009

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When, where and how the bridge breaks: anaphase bridge breakage plays a crucial role in gene amplification and HSR generation

Experimental cell research, 2005-01, Vol.302 (2), p.233-243

2005

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Nonselective DNA damage induced by a replication inhibitor results in the selective elimination of extrachromosomal double minutes from human cancer cells

Genes chromosomes & cancer, 2007-10, Vol.46 (10), p.865-874

2007

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Gene Amplification and the Extrachromosomal Circular DNA

Repeat induces not only gene silencing, but also gene activation in mammalian cells

Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells

Epigenetic Repeat-Induced Gene Silencing in the Chromosomal and Extrachromosomal Contexts in Human Cells

Targeted amplification of a sequence of interest in artificial chromosome in mammalian cells

Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures

Emergence of micronuclei and their effects on the fate of cells under replication stress

SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing

Dissection of the beta-globin replication-initiation region reveals specific requirements for replicator elements during gene amplification

Amplification of a transgene within a long array of replication origins favors higher gene expression in animal cells

LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation

An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells

Efficient recombinant production in mammalian cells using a novel IR/MAR gene amplification method

Generation of micronuclei during interphase by coupling between cytoplasmic membrane blebbing and nuclear budding

Fusion of the Dhfr/Mtx and IR/MAR gene amplification methods produces a rapid and efficient method for stable recombinant protein production

Double‐strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation

Cloning and Characterization of a Human Genomic Sequence that Alleviates Repeat-Induced Gene Silencing

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

Pressure overload inhibits glucocorticoid receptor transcriptional activity in cardiomyocytes and promotes pathological cardiac hypertrophy

How a replication origin and matrix attachment region accelerate gene amplification under replication stress in mammalian cells

Amplification of a plasmid bearing a mammalian replication initiation region in chromosomal and extrachromosomal contexts

Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice

Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis

When, where and how the bridge breaks: anaphase bridge breakage plays a crucial role in gene amplification and HSR generation

Nonselective DNA damage induced by a replication inhibitor results in the selective elimination of extrachromosomal double minutes from human cancer cells

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