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Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases

Biological and Pharmaceutical Bulletin, 2024/05/01, Vol.47(5), pp.886-894

Shimizu, Kahori

2024

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Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice

Biological and Pharmaceutical Bulletin, 2021/11/01, Vol.44(11), pp.1759-1766

2021

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Cranberry Attenuates Progression of Non-alcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice

Biological and Pharmaceutical Bulletin, 2019/08/01, Vol.42(8), pp.1295-1302

2019

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Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice

Journal of pharmacological sciences, 2022-11, Vol.150 (3), p.135-145

2022

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Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice

PloS one, 2022-09, Vol.17 (9), p.e0274297-e0274297

2022

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Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose‐stimulated insulin secretion

The FASEB journal, 2024-01, Vol.38 (2), p.e23425-n/a

2024

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Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3′-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver

Biological and Pharmaceutical Bulletin, 2021/10/01, Vol.44(10), pp.1506-1513

2021

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Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

The Journal of immunology (1950), 2021-01, Vol.206 (2), p.410-421

2021

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Dietary calamondin supplementation slows the progression of non-alcoholic fatty liver disease in C57BL/6 mice fed a high-fat diet

International journal of food sciences and nutrition, 2021-05, Vol.72 (3), p.335-347

2021

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ZFAND3 Overexpression in the Mouse Liver Improves Glucose Tolerance and Hepatic Insulin Resistance

Experimental and clinical endocrinology & diabetes, 2022-04, Vol.130 (4), p.254-261

2022

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Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice

BioMed research international, 2015-01, Vol.2015 (2015), p.1-10

2015

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Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis

Biochemistry and biophysics reports, 2017-07, Vol.10 (C), p.192-197

2017

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Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Molecular therapy. Methods & clinical development, 2014-01, Vol.1 (C), p.14035-14035, Article 14035

2014

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Development and Characterization of a Novel Adenovirus Vector Exhibiting MicroRNA-mediated Suppression of the Leaky Expression of Adenovirus Genes

YAKUGAKU ZASSHI, 2015/12/01, Vol.135(12), pp.1349-1356

Shimizu, Kahori

2015

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Further Reduction in Adenovirus Vector-Mediated Liver Transduction without Largely Affecting Transgene Expression in Target Organ by Exploiting MicroRNA-Mediated Regulation and the Cre-loxP Recombination System

Molecular pharmaceutics, 2012-12, Vol.9 (12), p.3452-3463

2012

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Development of Mice Exhibiting Hepatic Microsomal Activity of Human CYP3A4 Comparable to That in Human Liver Microsomes by Intravenous Administration of an Adenovirus Vector Expressing Human CYP3A4

Drug metabolism and pharmacokinetics, 2014, Vol.29 (4), p.296-304

2014

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Development of a Novel Method for the Treatment and Prevention of Diabetes Mellitus

YAKUGAKU ZASSHI, 2019/01/01, Vol.139(1), pp.39-39

2019

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Transplacental delivery of factor IX Fc-fusion protein ameliorates bleeding phenotype of newborn hemophilia B mice

Journal of controlled release, 2024-10, Vol.374, p.415-424

2024

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Development of a Novel Method for the Treatment and Prevention of Diabetes Mellitus

Yakugaku zasshi, 2019-01, Vol.139 (1), p.39-39

2019

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Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

Pharmaceutics, 2011-07, Vol.3 (3), p.338-353

2011

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Development of Mice Exhibiting Hepatic Microsomal Activity of Human CYP3A4 Comparable to That in Human Liver Microsomes by Intravenous Administration of an Adenovirus Vector Expressing Human CYP3A4

DRUG METABOLISM AND PHARMACOKINETICS, 2014-08, Vol.29 (4), p.296-304

2014

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Identification and characterization of functional antioxidant response elements in the promoter of the aldo-keto reductase AKR1B10 gene

Chemico-biological interactions, 2017-10, Vol.276, p.160-166

2017

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Cooperative regulation of mouse aldose reductase (AKR1B3) gene transcription by Nrf2, TonEBP, and c-jun

Chemico-biological interactions, 2019-04, Vol.302, p.36-45

2019

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Vesicular storage and secretion of l‐glutamate from glucagon‐like peptide 1‐secreting clonal intestinal L cells

Journal of neurochemistry, 2006-01, Vol.96 (2), p.550-560

2006

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The Investigation of Genes, Using an Improved Adenovirus Vector, and Food for the Treatment and Prevention of Type 2 Diabetes Mellitus

YAKUGAKU ZASSHI, 2019/01/01, Vol.139(1), pp.47-51

2019

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Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases

Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice

Cranberry Attenuates Progression of Non-alcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice

Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice

Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice

Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose‐stimulated insulin secretion

Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3′-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver

Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

Dietary calamondin supplementation slows the progression of non-alcoholic fatty liver disease in C57BL/6 mice fed a high-fat diet

ZFAND3 Overexpression in the Mouse Liver Improves Glucose Tolerance and Hepatic Insulin Resistance

Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Development and Characterization of a Novel Adenovirus Vector Exhibiting MicroRNA-mediated Suppression of the Leaky Expression of Adenovirus Genes

Further Reduction in Adenovirus Vector-Mediated Liver Transduction without Largely Affecting Transgene Expression in Target Organ by Exploiting MicroRNA-Mediated Regulation and the Cre-loxP Recombination System

Development of Mice Exhibiting Hepatic Microsomal Activity of Human CYP3A4 Comparable to That in Human Liver Microsomes by Intravenous Administration of an Adenovirus Vector Expressing Human CYP3A4

Development of a Novel Method for the Treatment and Prevention of Diabetes Mellitus

Transplacental delivery of factor IX Fc-fusion protein ameliorates bleeding phenotype of newborn hemophilia B mice

Development of a Novel Method for the Treatment and Prevention of Diabetes Mellitus

Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

Development of Mice Exhibiting Hepatic Microsomal Activity of Human CYP3A4 Comparable to That in Human Liver Microsomes by Intravenous Administration of an Adenovirus Vector Expressing Human CYP3A4

Identification and characterization of functional antioxidant response elements in the promoter of the aldo-keto reductase AKR1B10 gene

Cooperative regulation of mouse aldose reductase (AKR1B3) gene transcription by Nrf2, TonEBP, and c-jun

Vesicular storage and secretion of l‐glutamate from glucagon‐like peptide 1‐secreting clonal intestinal L cells

The Investigation of Genes, Using an Improved Adenovirus Vector, and Food for the Treatment and Prevention of Type 2 Diabetes Mellitus

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