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Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models

British journal of cancer, 2022-03, Vol.126 (5), p.744-753

2022

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Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing

PloS one, 2011-04, Vol.6 (4), p.e18410-e18410

2011

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Periostin Is Expressed in Pericryptal Fibroblasts and Cancer-associated Fibroblasts in the Colon

The journal of histochemistry and cytochemistry, 2008-08, Vol.56 (8), p.753-764

2008

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Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos–overexpressing bone lesions

Human pathology, 2009-02, Vol.40 (2), p.226-237

2009

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Clinical activity of ASP8273 in Asian patients with non‐small‐cell lung cancer with EGFR activating and T790M mutations

Cancer science, 2018-09, Vol.109 (9), p.2852-2862

2018

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Periostin associates with Notch1 precursor to maintain Notch1 expression under a stress condition in mouse cells

PloS one, 2010-08, Vol.5 (8), p.e12234-e12234

2010

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Virtual clinical trial simulations for a novel KRASG12C inhibitor (ASP2453) in non‐small cell lung cancer

CPT: pharmacometrics and systems pharmacology, 2021-08, Vol.10 (8), p.864-877

2021

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GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen

Genesis (New York, N.Y. : 2000), 2007-02, Vol.45 (2), p.90-100

2007

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Periostin is essential for cardiac healing after acute myocardial infarction

The Journal of experimental medicine, 2008-02, Vol.205 (2), p.295-303

2008

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Impaired capsule formation of tumors in periostin-null mice

Biochemical and biophysical research communications, 2008-03, Vol.367 (4), p.736-742

2008

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Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity

Bioorganic & medicinal chemistry, 2022-10, Vol.71, p.116949-116949, Article 116949

2022

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Abstract A173: ASP2074, a novel tetraspanin 8 x CD3 bispecific antibody, demonstrates selectivity and antitumor activity in preclinical cancer models

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.A173-A173

2023

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Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors

Bioorganic & medicinal chemistry, 2024-01, Vol.98, p.117581-117581, Article 117581

2024

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Periostin is essential for cardiac healingafter acute myocardial infarction

The Journal of experimental medicine, 2008-02, Vol.205 (2), p.295-303

2008

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Abstract 2962: ASP2138, a novel 2+1 format, claudin 18.2 x CD3 bispecific antibody, demonstrates selectivity and activity in preclinical cancer models

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2962-2962

2023

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Abstract LB246: Enfortumab vedotin, a nectin-4-directed antibody-drug conjugate, demonstrates compelling antitumor activity in non-muscle invasive bladder cancer models which predicts minimal systemic exposure when administered by intravesical instillation in patients

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB246-LB246

2023

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Virtual clinical trial simulations for a novel KRAS G12C inhibitor (ASP2453) in non-small cell lung cancer

CPT: pharmacometrics and systems pharmacology, 2021-08, Vol.10 (8), p.864-877

2021

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Clinical activity of ASP 8273 in Asian patients with non‐small‐cell lung cancer with EGFR activating and T790M mutations

Cancer science, 2018-09, Vol.109 (9), p.2852-2862

2018

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Abstract 1140: Enfortumab vedotin, a Nectin-4 directed ADC, demonstrates compelling tolerability and anti-tumor activity with intravesical instillation in preclinical models of non-muscle invasive bladder cancer

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.1140-1140

2022

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Periostin, acting in regeneration of periodontal ligament, contributes to cardiac healing and tumor capsule formation

Fukuoka igaku zasshi = Hukuoka acta medica, 2009-03, Vol.100 (3), p.67-74

2009

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Periostin is essential for cardiac healing after acute myocardial infarction

The Journal of cell biology, 2008-01, Vol.180 (2), p.i7-i7

2008

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歯根膜再生に機能するペリオスチンの心筋梗塞修復, 癌被膜形成への寄与

福岡医学雑誌, 2009-03, Vol.100 (3), p.67-74

2009

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Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease

World journal of hepatology, 2015-11, Vol.7 (27), p.2749-2756

2015

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Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C

World journal of gastroenterology : WJG, 2014-02, Vol.20 (5), p.1289-1297

2014

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Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

World journal of gastroenterology : WJG, 2015-09, Vol.21 (35), p.10215-10223

2015

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Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models

Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing

Periostin Is Expressed in Pericryptal Fibroblasts and Cancer-associated Fibroblasts in the Colon

Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos–overexpressing bone lesions

Clinical activity of ASP8273 in Asian patients with non‐small‐cell lung cancer with EGFR activating and T790M mutations

Periostin associates with Notch1 precursor to maintain Notch1 expression under a stress condition in mouse cells

Virtual clinical trial simulations for a novel KRASG12C inhibitor (ASP2453) in non‐small cell lung cancer

GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen

Periostin is essential for cardiac healing after acute myocardial infarction

Impaired capsule formation of tumors in periostin-null mice

Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity

Abstract A173: ASP2074, a novel tetraspanin 8 x CD3 bispecific antibody, demonstrates selectivity and antitumor activity in preclinical cancer models

Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors

Periostin is essential for cardiac healingafter acute myocardial infarction

Abstract 2962: ASP2138, a novel 2+1 format, claudin 18.2 x CD3 bispecific antibody, demonstrates selectivity and activity in preclinical cancer models

Abstract LB246: Enfortumab vedotin, a nectin-4-directed antibody-drug conjugate, demonstrates compelling antitumor activity in non-muscle invasive bladder cancer models which predicts minimal systemic exposure when administered by intravesical instillation in patients

Virtual clinical trial simulations for a novel KRAS G12C inhibitor (ASP2453) in non-small cell lung cancer

Clinical activity of ASP 8273 in Asian patients with non‐small‐cell lung cancer with EGFR activating and T790M mutations

Abstract 1140: Enfortumab vedotin, a Nectin-4 directed ADC, demonstrates compelling tolerability and anti-tumor activity with intravesical instillation in preclinical models of non-muscle invasive bladder cancer

Periostin, acting in regeneration of periodontal ligament, contributes to cardiac healing and tumor capsule formation

Periostin is essential for cardiac healing after acute myocardial infarction

歯根膜再生に機能するペリオスチンの心筋梗塞修復, 癌被膜形成への寄与

Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease

Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C

Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

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