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Two Randomized Trials of Linaclotide for Chronic Constipation

The New England journal of medicine, 2011-08, Vol.365 (6), p.527-536

2011

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Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial

PloS one, 2015-07, Vol.10 (7), p.e0134349-e0134349

2015

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Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

The American journal of gastroenterology, 2012-11, Vol.107 (11), p.1702-1712

2012

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A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

The American journal of gastroenterology, 2012-11, Vol.107 (11), p.1714-1724

2012

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Response to Miner et al

The American journal of gastroenterology, 2017-11, Vol.112 (11), p.1750-1751

2017

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Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation

Clinical gastroenterology and hepatology, 2014-04, Vol.12 (4), p.616-623

2014

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A review of the clinical efficacy of linaclotide in irritable bowel syndrome with constipation

Current medical research and opinion, 2013-02, Vol.29 (2), p.149-160

2013

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Tu1070 The Effect of Linaclotide on IBS-QOL Sexual Subscale Scores in Patients With Irritable Bowel Syndrome With Constipation: Results From a Post Hoc Analysis of 2 Phase 3 Trials of Linaclotide

Gastroenterology (New York, N.Y. 1943), 2013-05, Vol.144 (5), p.S-752-S-753

2013

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Sa2008 Efficacy and Safety of Linaclotide in Chronic Idiopathic Constipation Patients With Abdominal Bloating: Phase 3b Trial Results

Gastroenterology (New York, N.Y. 1943), 2014-05, Vol.146 (5), p.S-353-S-353

2014

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Efficacy and Safety of Once Daily Linaclotide in Patients With Irritable Bowel Syndrome With Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial Followed by a 4-Week Randomized Withdrawal Period

Gastroenterology (New York, N.Y. 1943), 2011, Vol.140 (5), p.S-138-S-138

2011

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Tu1401 Factors Contributing to Treatment Satisfaction in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) Treated With Linaclotide vs Placebo

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-822-S-823

2012

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Tu1380 Assessing the Percent of Days Linaclotide Improved Abdominal Symptoms and Stool Frequency in Patients With IBS-C: A Pooled Analysis of Two Phase 3 Trials

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-816-S-817

2012

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Su2033 Determining the Minimum Duration for Initial Treatment With Linaclotide in IBS-C Patients: Results From Pooled Phase 3 Trials

Gastroenterology (New York, N.Y. 1943), 2013-05, Vol.144 (5), p.S-537-S-538

2013

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Mo2054 Assessing Abdominal and Bowel Symptoms Using Adequate Relief Based Thresholds: Results From 2 Phase 3 Trials of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

Gastroenterology (New York, N.Y. 1943), 2013-05, Vol.144 (5), p.S-728-S-729

2013

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Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

Biochemical pharmacology, 1996-07, Vol.52 (2), p.237-245

1996

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Assessment of treatment response in chronic constipation clinical trials

Clinical and experimental gastroenterology, 2014, Vol.7 (default), p.191-198

2014

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Sa1603 OBETICHOLIC ACID TREATMENT OF FIBROSIS DUE TO NONALCOHOLIC STEATOHEPATITIS REDUCES INCIDENCE OF DIARRHEA BUT INCREASES CONSTIPATION: AN ANALYSIS BASED ON ADVERSE EVENTS FROM THE REGENERATE TRIAL

Gastroenterology (New York, N.Y. 1943), 2023-05, Vol.164 (6), p.S-1310-S-1310

2023

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Cyclooxygenase inhibitors: drugs for cancer prevention

Current opinion in pharmacology, 2003-08, Vol.3 (4), p.352-361

2003

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Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention

Oral oncology, 2005-07, Vol.41 (6), p.562-567

2005

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Sa1098 Mediation Analysis Supports a Direct Effect of Linaclotide on Relief of Abdominal Pain Independent of Constipation Improvement

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-215-S-216

2012

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Tu1069 Do Baseline Factors Contribute to Treatment Satisfaction in Patients With Chronic Constipation Treated With Linaclotide vs Placebo?

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-737-S-738

2012

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Mo1856 Linaclotide Significantly Improved Abdominal Pain Compared With Placebo in Patients With Irritable Bowel Syndrome Regardless of Baseline Pain Severity in Two Phase 3 Trials

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-701-S-701

2012

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Tu1423 Effects of Linaclotide on Straining Associated With Bowel Movements in Patients With Irritable Bowel Syndrome With Constipation (IBS-C): A Post Hoc Analysis of Pooled Data From Two Phase 3 Trials

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-828-S-829

2012

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Mo1858 Characterization and Association of Abdominal Pain With Anxiety or Depression in Patients With Irritable Bowel Syndrome With Constipation

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-701-S-702

2012

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Results from a new efficacy and safety analysis of the REGENERATE trial of obeticholic acid for treatment of pre-cirrhotic fibrosis due to non-alcoholic steatohepatitis

Two Randomized Trials of Linaclotide for Chronic Constipation

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

Response to Miner et al

Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation

A review of the clinical efficacy of linaclotide in irritable bowel syndrome with constipation

Tu1070 The Effect of Linaclotide on IBS-QOL Sexual Subscale Scores in Patients With Irritable Bowel Syndrome With Constipation: Results From a Post Hoc Analysis of 2 Phase 3 Trials of Linaclotide

Sa2008 Efficacy and Safety of Linaclotide in Chronic Idiopathic Constipation Patients With Abdominal Bloating: Phase 3b Trial Results

Efficacy and Safety of Once Daily Linaclotide in Patients With Irritable Bowel Syndrome With Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial Followed by a 4-Week Randomized Withdrawal Period

Tu1401 Factors Contributing to Treatment Satisfaction in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) Treated With Linaclotide vs Placebo

Tu1380 Assessing the Percent of Days Linaclotide Improved Abdominal Symptoms and Stool Frequency in Patients With IBS-C: A Pooled Analysis of Two Phase 3 Trials

Su2033 Determining the Minimum Duration for Initial Treatment With Linaclotide in IBS-C Patients: Results From Pooled Phase 3 Trials

Mo2054 Assessing Abdominal and Bowel Symptoms Using Adequate Relief Based Thresholds: Results From 2 Phase 3 Trials of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

Assessment of treatment response in chronic constipation clinical trials

Sa1603 OBETICHOLIC ACID TREATMENT OF FIBROSIS DUE TO NONALCOHOLIC STEATOHEPATITIS REDUCES INCIDENCE OF DIARRHEA BUT INCREASES CONSTIPATION: AN ANALYSIS BASED ON ADVERSE EVENTS FROM THE REGENERATE TRIAL

Cyclooxygenase inhibitors: drugs for cancer prevention

Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention

Sa1098 Mediation Analysis Supports a Direct Effect of Linaclotide on Relief of Abdominal Pain Independent of Constipation Improvement

Tu1069 Do Baseline Factors Contribute to Treatment Satisfaction in Patients With Chronic Constipation Treated With Linaclotide vs Placebo?

Mo1856 Linaclotide Significantly Improved Abdominal Pain Compared With Placebo in Patients With Irritable Bowel Syndrome Regardless of Baseline Pain Severity in Two Phase 3 Trials

Tu1423 Effects of Linaclotide on Straining Associated With Bowel Movements in Patients With Irritable Bowel Syndrome With Constipation (IBS-C): A Post Hoc Analysis of Pooled Data From Two Phase 3 Trials

Mo1858 Characterization and Association of Abdominal Pain With Anxiety or Depression in Patients With Irritable Bowel Syndrome With Constipation

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