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Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance–Associated Protein 2 and Breast Cancer Resistance Protein

Journal of pharmaceutical sciences, 2016-01, Vol.105 (1), p.343-349

2016

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Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats

Journal of pharmaceutical sciences, 2010-04, Vol.99 (4), p.2185-2195

2010

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Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats

Biomedical chromatography, 2016-10, Vol.30 (10), p.1641-1647

2016

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Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, and clinical activity of OBI-3424 in patients with advanced or metastatic solid tumors

British journal of cancer, 2023-08, Vol.129 (2), p.266-274

2023

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Suppression on metastasis by rhubarb through modulation on MMP-2 and uPA in human A549 lung adenocarcinoma: An ex vivo approach

Journal of ethnopharmacology, 2011-01, Vol.133 (2), p.426-433

2011

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Metabolism and Pharmacokinetics of San-Huang-Xie-Xin-Tang, a Polyphenol-Rich Chinese Medicine Formula, in Rats and Ex-Vivo Antioxidant Activity

Evidence-based complementary and alternative medicine, 2011-01, Vol.2011 (2011), p.1-9

2011

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OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL

Clinical cancer research, 2019-07, Vol.25 (14), p.4493-4503

2019

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Interaction of rhubarb and methotrexate in rats: in vivo and ex vivo approaches

The American journal of Chinese medicine (1979), 2013, Vol.41 (6), p.1427-1438

2013

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Preclinical Studies of OBI-999: A Novel Globo H-Targeting Antibody-Drug Conjugate

Molecular cancer therapeutics, 2021-06, Vol.20 (6), p.1121-1132

2021

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Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats

Evidence-based complementary and alternative medicine, 2012-01, Vol.2012 (2012), p.1-8

2012

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Noni increased the systemic exposure of methotrexate in rats through inhibition on multi-drug resistance protein 2 (MRP 2) and breast cancer resistance protein (BCRP)

Journal of functional foods, 2013-07, Vol.5 (3), p.1414-1420

2013

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Metabolism and Pharmacokinetics of 3,3′,4′,7-Tetrahydroxyflavone (Fisetin), 5-Hydroxyflavone, and 7-Hydroxyflavone and Antihemolysis Effects of Fisetin and Its Serum Metabolites

Journal of agricultural and food chemistry, 2009-01, Vol.57 (1), p.83-89

2009

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Potential Risk of Mulberry–Drug Interaction: Modulation on P‑Glycoprotein and Cytochrome P450 3A

Journal of agricultural and food chemistry, 2013-05, Vol.61 (18), p.4464-4469

2013

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Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats

Journal of ethnopharmacology, 2011-10, Vol.137 (3), p.1388-1394

2011

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Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A

Xenobiotica, 2016-08, Vol.46 (8), p.677-682

2016

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Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity

Planta medica, 2009-10, Vol.75 (13), p.1386-1392

2009

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Potential ex vivo immunomodulatory effects of San-Huang-Xie-Xin-Tang and its component herbs on mice and humans

Journal of ethnopharmacology, 2010-02, Vol.127 (2), p.292-298

2010

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Abstract 1220: Selective and broad anti-tumor activity of AKR1C3-activated prodrug AST-3424/OBI-3424

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1220-1220

2021

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Abstract 4814: Specificity, biodistribution, tumor targeting, and pharmacokinetics of a novel humanized anti-Globo H antibody, OBI-888, for cancer immunotherapy

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.4814-4814

2019

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Abstract 955: Preclinical characterization of a novel SSEA-4-targeting antibody drug conjugate, OBI-998

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.955-955

2021

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Abstract 4815: Novel Globo H targeting antibody-drug conjugate with binding specificity and anti-tumor efficacy in multiple cancer types

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.4815-4815

2019

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First-in-Human Study of OBI-999, a Globo H-Targeting Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors

JCO precision oncology, 2023-01, Vol.7 (7), p.e2200496

2023

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Abstract 7179: OBI-992, a novel TROP2 targeting antibody drug conjugate demonstrates superior in vivo PK/PD properties and a favorable safety profile

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.7179-7179

2024

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Abstract 3149: Development of a novel site-specific ADC glycan platform with potential for improved in vivo efficacy and stability of the ADC in animal studies

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.3149-3149

2024

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A novel selective AKR1C3-activated prodrug AST-3424/OBI-3424 exhibits broad anti-tumor activity

American journal of cancer research, 2023-11, Vol.13 (11), p.5750-5750

2023

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Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance–Associated Protein 2 and Breast Cancer Resistance Protein

Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats

Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats

Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, and clinical activity of OBI-3424 in patients with advanced or metastatic solid tumors

Suppression on metastasis by rhubarb through modulation on MMP-2 and uPA in human A549 lung adenocarcinoma: An ex vivo approach

Metabolism and Pharmacokinetics of San-Huang-Xie-Xin-Tang, a Polyphenol-Rich Chinese Medicine Formula, in Rats and Ex-Vivo Antioxidant Activity

OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL

Interaction of rhubarb and methotrexate in rats: in vivo and ex vivo approaches

Preclinical Studies of OBI-999: A Novel Globo H-Targeting Antibody-Drug Conjugate

Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats

Noni increased the systemic exposure of methotrexate in rats through inhibition on multi-drug resistance protein 2 (MRP 2) and breast cancer resistance protein (BCRP)

Metabolism and Pharmacokinetics of 3,3′,4′,7-Tetrahydroxyflavone (Fisetin), 5-Hydroxyflavone, and 7-Hydroxyflavone and Antihemolysis Effects of Fisetin and Its Serum Metabolites

Potential Risk of Mulberry–Drug Interaction: Modulation on P‑Glycoprotein and Cytochrome P450 3A

Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats

Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A

Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity

Potential ex vivo immunomodulatory effects of San-Huang-Xie-Xin-Tang and its component herbs on mice and humans

Abstract 1220: Selective and broad anti-tumor activity of AKR1C3-activated prodrug AST-3424/OBI-3424

Abstract 4814: Specificity, biodistribution, tumor targeting, and pharmacokinetics of a novel humanized anti-Globo H antibody, OBI-888, for cancer immunotherapy

Abstract 955: Preclinical characterization of a novel SSEA-4-targeting antibody drug conjugate, OBI-998

Abstract 4815: Novel Globo H targeting antibody-drug conjugate with binding specificity and anti-tumor efficacy in multiple cancer types

First-in-Human Study of OBI-999, a Globo H-Targeting Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors

Abstract 7179: OBI-992, a novel TROP2 targeting antibody drug conjugate demonstrates superior in vivo PK/PD properties and a favorable safety profile

Abstract 3149: Development of a novel site-specific ADC glycan platform with potential for improved in vivo efficacy and stability of the ADC in animal studies

A novel selective AKR1C3-activated prodrug AST-3424/OBI-3424 exhibits broad anti-tumor activity

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