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Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond

Analytical chemistry (Washington), 2019-08, Vol.91 (15), p.9472-9480

2019

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Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

Science translational medicine, 2018-12, Vol.10 (472)

2018

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Steady-State Kinetic and Inhibition Studies of the Mammalian Target of Rapamycin (mTOR) Kinase Domain and mTOR Complexes

Biochemistry (Easton), 2010-10, Vol.49 (39), p.8488-8498

2010

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Next generation Fc scaffold for multispecific antibodies

iScience, 2021-12, Vol.24 (12), p.103447-103447, Article 103447

2021

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Phosphopeptide/Phosphoprotein Mapping by Electron Capture Dissociation Mass Spectrometry

Analytical chemistry (Washington), 2001-01, Vol.73 (1), p.19-22

2001

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External Accumulation of Ions for Enhanced Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Journal of the American Society for Mass Spectrometry, 1997-09, Vol.8 (9), p.970-976

1997

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High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein

mAbs, 2017-07, Vol.9 (5), p.812-819

2017

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Quantitative Phosphoproteomic Analysis of the STAT3/IL-6/HIF1α Signaling Network: An Initial Study in GSC11 Glioblastoma Stem Cells

Journal of proteome research, 2010-01, Vol.9 (1), p.430-443

2010

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Supercritical Fluid Chromatography Reduction of Hydrogen/Deuterium Back Exchange in Solution-Phase Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis

Analytical chemistry (Washington), 2006-10, Vol.78 (19), p.7058-7060

2006

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Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells

mAbs, 2018-11, Vol.10 (8), p.1291-1300

2018

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Application of Micro-Electrospray Liquid Chromatography Techniques to FT-ICR MS to Enable High-Sensitivity Biological Analysis

Journal of the American Society for Mass Spectrometry, 1998-04, Vol.9 (4), p.333-340

1998

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Discovery of a Novel B-Raf Fusion Protein Related to c-Met Drug Resistance

Journal of proteome research, 2011-11, Vol.10 (11), p.5084-5094

2011

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Scaling MS plateaus with high-resolution FT-ICRMS

Analytical chemistry (Washington), 2002-05, Vol.74 (9), p.252A-259A

2002

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Identification, Composition, and Asymmetric Formation Mechanism of Glycidyl Methacrylate/Butyl Methacrylate Copolymers up to 7000 Da from Electrospray Ionization Ultrahigh-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Analytical chemistry (Washington), 1998-08, Vol.70 (15), p.3220-3226

1998

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Structural validation of saccharomicins by high resolution and high mass accuracy fourier transform-ion cyclotron resonance-mass spectrometry and infrared multiphoton dissociation tandem mass spectrometry

Journal of the American Society for Mass Spectrometry, 1999-12, Vol.10 (12), p.1285-1290

1999

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Protein–inhibitor complexes analyzed by alkaline capillary LC–MS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-10, Vol.825 (2), p.176-185

2005

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Tool command language automation of the modular ion cyclotron data acquisition system (MIDAS) for data-dependent tandem Fourier transform ion cyclotron resonance mass spectrometry

Rapid communications in mass spectrometry, 2003-01, Vol.17 (4), p.363-370

2003

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Counting Individual Sulfur Atoms in a Protein by Ultrahigh-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Experimental Resolution of Isotopic Fine Structure in Proteins

Proceedings of the National Academy of Sciences - PNAS, 1998-09, Vol.95 (20), p.11532-11537

1998

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Fourier transform ion cyclotron resonance mass spectrometry in a high homogeneity 25 tesla resistive magnet

Journal of the American Society for Mass Spectrometry, 1999-03, Vol.10 (3), p.265-268

1999

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Gas-Phase RNA and DNA Ions. 1. H/D Exchange of the [M − H]- Anions of Nucleoside 5‘-Monophosphates (GMP, dGMP, AMP, dAMP, CMP, dCMP, UMP, dTMP), Ribose 5-Monophosphate, and 2-Deoxyribose 5-Monophosphate with D2O and D2S

Journal of the American Chemical Society, 1998-10, Vol.120 (39), p.10187-10193

1998

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Abstract 2474: Antitumoral efficacy of ASKG812, a Smartkine® based bifunctional PD-1-eIL-2 molecule, through enhancing T effector cis agonism

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.2474-2474

2024

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O-Glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins: Attachment of glycosaminoglycans and other intermediates with phosphorylation at the xylose sugar subunit

mAbs, 2014-07, Vol.6 (4), p.904-914

2014

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Digital Quadrature Heterodyne Detection for High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Analytical chemistry (Washington), 1999-10, Vol.71 (20), p.4758-4763

1999

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Counting individual sulfur atoms in a protein by ultrahighresolution Fourier transform ion cyclotron resonance mass spectrometry: Experimental resolution of isotopic fine structure in proteins

Proceedings of the National Academy of Sciences - PNAS, 1998-09, Vol.95 (20), p.11532-11537

1998

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Protected hinge in the immunoglobulin G2‐A 2 disulfide isoform

Protein science, 2014-12, Vol.23 (12), p.1753-1764

2014

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Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

Steady-State Kinetic and Inhibition Studies of the Mammalian Target of Rapamycin (mTOR) Kinase Domain and mTOR Complexes

Next generation Fc scaffold for multispecific antibodies

Phosphopeptide/Phosphoprotein Mapping by Electron Capture Dissociation Mass Spectrometry

External Accumulation of Ions for Enhanced Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein

Quantitative Phosphoproteomic Analysis of the STAT3/IL-6/HIF1α Signaling Network: An Initial Study in GSC11 Glioblastoma Stem Cells

Supercritical Fluid Chromatography Reduction of Hydrogen/Deuterium Back Exchange in Solution-Phase Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis

Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells

Application of Micro-Electrospray Liquid Chromatography Techniques to FT-ICR MS to Enable High-Sensitivity Biological Analysis

Discovery of a Novel B-Raf Fusion Protein Related to c-Met Drug Resistance

Scaling MS plateaus with high-resolution FT-ICRMS

Identification, Composition, and Asymmetric Formation Mechanism of Glycidyl Methacrylate/Butyl Methacrylate Copolymers up to 7000 Da from Electrospray Ionization Ultrahigh-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Structural validation of saccharomicins by high resolution and high mass accuracy fourier transform-ion cyclotron resonance-mass spectrometry and infrared multiphoton dissociation tandem mass spectrometry

Protein–inhibitor complexes analyzed by alkaline capillary LC–MS

Tool command language automation of the modular ion cyclotron data acquisition system (MIDAS) for data-dependent tandem Fourier transform ion cyclotron resonance mass spectrometry

Counting Individual Sulfur Atoms in a Protein by Ultrahigh-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Experimental Resolution of Isotopic Fine Structure in Proteins

Fourier transform ion cyclotron resonance mass spectrometry in a high homogeneity 25 tesla resistive magnet

Gas-Phase RNA and DNA Ions. 1. H/D Exchange of the [M − H]- Anions of Nucleoside 5‘-Monophosphates (GMP, dGMP, AMP, dAMP, CMP, dCMP, UMP, dTMP), Ribose 5-Monophosphate, and 2-Deoxyribose 5-Monophosphate with D2O and D2S

Abstract 2474: Antitumoral efficacy of ASKG812, a Smartkine® based bifunctional PD-1-eIL-2 molecule, through enhancing T effector cis agonism

O-Glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins: Attachment of glycosaminoglycans and other intermediates with phosphorylation at the xylose sugar subunit

Digital Quadrature Heterodyne Detection for High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Counting individual sulfur atoms in a protein by ultrahighresolution Fourier transform ion cyclotron resonance mass spectrometry: Experimental resolution of isotopic fine structure in proteins

Protected hinge in the immunoglobulin G2‐A 2 disulfide isoform

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