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Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

The Journal of biological chemistry, 2014-06, Vol.289 (26), p.18008-18021

2014

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Structural basis of CX-4945 binding to human protein kinase CK2

FEBS letters, 2011-01, Vol.585 (1), p.104-110

2011

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Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

PLoS pathogens, 2016-05, Vol.12 (5), p.e1005585-e1005585

2016

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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies

SLAS discovery, 2022-01, Vol.27 (1), p.20-28

2022

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Selective small-molecule inhibition of an RNA structural element

Nature (London), 2015-10, Vol.526 (7575), p.672-677

2015

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Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2

Analytical chemistry (Washington), 2021-04, Vol.93 (15), p.6071-6079

2021

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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain

Biochemistry (Easton), 2010-09, Vol.49 (38), p.8350-8358

2010

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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Science translational medicine, 2016-03, Vol.8 (329), p.329ra32

2016

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Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling

Antimicrobial agents and chemotherapy, 2015-02, Vol.59 (2), p.1052-1060

2015

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Mapping Lipogenic Flux: A Gold LDI–MS Approach for Imaging Neutral Lipid Kinetics

Journal of the American Society for Mass Spectrometry, 2020-12, Vol.31 (12), p.2421-2425

2020

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Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli

Archives of biochemistry and biophysics, 2010-11, Vol.503 (2), p.191-201

2010

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Examining Targeted Protein Degradation from Physiological and Analytical Perspectives: Enabling Translation between Cells and Subjects

ACS chemical biology, 2020-10, Vol.15 (10), p.2623-2635

2020

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Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS

Analytical biochemistry, 2017-02, Vol.518, p.9-15

2017

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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4743-4747

2016

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Fully Activated MEK1 Exhibits Compromised Affinity for Binding of Allosteric Inhibitors U0126 and PD0325901

Biochemistry (Easton), 2011-09, Vol.50 (37), p.7964-7976

2011

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Affinity characterization–mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution

Analytical biochemistry, 2011-11, Vol.418 (1), p.10-18

2011

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SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics

Molecular cancer therapeutics, 2010-11, Vol.9 (11), p.2993-3002

2010

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Thermodynamics of Nucleotide and Inhibitor Binding to Wild-Type and Ispinesib-Resistant Forms of Human Kinesin Spindle Protein

Biochemistry (Easton), 2009-11, Vol.48 (46), p.11045-11055

2009

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Biochemical Basis for the Functional Switch That Regulates Hepatocyte Growth Factor Receptor Tyrosine Kinase Activation

Biochemistry (Easton), 2008-04, Vol.47 (13), p.4028-4038

2008

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Oligomerization-Induced Differential Dephosphorylation of c-Met Receptor Tyrosine Kinase

Biochemistry (Easton), 2005-08, Vol.44 (33), p.10984-10993

2005

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Purification and characterization of truncated human AMPK α2β2γ3 heterotrimer from baculovirus-infected insect cells

Protein expression and purification, 2010-03, Vol.70 (1), p.13-22

2010

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Biochemical Basis for the Functional Switch That Regulates Hepatocyte Growth Factor Receptor Tyrosine Kinase Activation super([dagger])

Biochemistry (Easton), 2008-01, Vol.47 (13), p.4028-4038

2008

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Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells

Protein expression and purification, 2010-03, Vol.70 (1), p.13-22

2010

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A mechanism of activation of c-MET receptor tyrosine kinase

Sheth, Payal R

2006

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Nature structural & molecular biology, 2017-07, Vol.24 (7), p.570

2017

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Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

Structural basis of CX-4945 binding to human protein kinase CK2

Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies

Selective small-molecule inhibition of an RNA structural element

Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2

Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling

Mapping Lipogenic Flux: A Gold LDI–MS Approach for Imaging Neutral Lipid Kinetics

Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli

Examining Targeted Protein Degradation from Physiological and Analytical Perspectives: Enabling Translation between Cells and Subjects

Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus

Fully Activated MEK1 Exhibits Compromised Affinity for Binding of Allosteric Inhibitors U0126 and PD0325901

Affinity characterization–mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution

SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics

Thermodynamics of Nucleotide and Inhibitor Binding to Wild-Type and Ispinesib-Resistant Forms of Human Kinesin Spindle Protein

Biochemical Basis for the Functional Switch That Regulates Hepatocyte Growth Factor Receptor Tyrosine Kinase Activation

Oligomerization-Induced Differential Dephosphorylation of c-Met Receptor Tyrosine Kinase

Purification and characterization of truncated human AMPK α2β2γ3 heterotrimer from baculovirus-infected insect cells

Biochemical Basis for the Functional Switch That Regulates Hepatocyte Growth Factor Receptor Tyrosine Kinase Activation super([dagger])

Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells

A mechanism of activation of c-MET receptor tyrosine kinase

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

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