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The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors

Medicinal research reviews, 2000-07, Vol.20 (4), p.231-293

2000

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In Vitro Antibacterial Potency and Spectrum of ABT-492, a New Fluoroquinolone

Antimicrobial Agents and Chemotherapy, 2003-10, Vol.47 (10), p.3260-3269

2003

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DNA Sequence Specificity for Topoisomerase II Poisoning by the Quinoxaline Anticancer Drugs XK469 and CQS

Molecular pharmacology, 2003-06, Vol.63 (6), p.1382-1388

2003

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Novel Antibacterial Class

Antimicrobial Agents and Chemotherapy, 2003-12, Vol.47 (12), p.3831-3839

2003

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Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNA

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1890-1897

2005

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Synthesis and Antimicrobial Activity of 4H-4-Oxoquinolizine Derivatives: Consequences of Structural Modification at the C-8 Position

Journal of medicinal chemistry, 1999-10, Vol.42 (20), p.4202-4213

1999

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Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model

Biochemistry (Easton), 1989-05, Vol.28 (9), p.3886-3894

1989

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DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones

Antimicrobial Agents and Chemotherapy, 1999-07, Vol.43 (7), p.1574-1577

1999

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Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA

Biochemistry (Easton), 1989-05, Vol.28 (9), p.3879-3885

1989

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Quinobenoxazines: A Class of Novel Antitumor Quinolones and Potent Mammalian DNA Topoisomerase II Catalytic Inhibitors

Biochemistry (Easton), 1994-09, Vol.33 (37), p.11333-11339

1994

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Topoisomerase II Poisoning by ICRF-193

The Journal of biological chemistry, 2001-11, Vol.276 (48), p.44488-44494

2001

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Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIα/β poison

Cancer research (Chicago, Ill.), 2000-11, Vol.60 (21), p.5937-5940

2000

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Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents

Journal of medicinal chemistry, 1996-08, Vol.39 (16), p.3070-3088

1996

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Quinolones, 2-Pyridones and Resistant Type II DNA Topoisomerases

Current pharmaceutical design, 1997-04, Vol.3 (2), p.169-176

1997

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Mechanism of differential activities of ofloxacin enantiomers

Antimicrobial Agents and Chemotherapy, 1996-08, Vol.40 (8), p.1775-1784

1996

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ABT‐279 is a potent and selective inhibitor of DPPIV

The FASEB journal, 2006-03, Vol.20 (5), p.LB54-LB54

2006

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Mass-length ratio of fibrin fibers from gel permeation and light scattering

Biopolymers, 1977-01, Vol.16 (1), p.1-15

1977

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Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2-trans-phenylcyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Journal of medicinal chemistry, 1986-10, Vol.29 (10), p.2044-2047

1986

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Mechanism of Inhibition of DNA Gyrase by Analogues of Nalidixic Acid: The Target of the Drugs is DNA

Proceedings of the National Academy of Sciences - PNAS, 1985-01, Vol.82 (2), p.307-311

1985

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Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4,4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid

Journal of medicinal chemistry, 1984-03, Vol.27 (3), p.306-310

1984

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Molecular Mechanisms of DNA Gyrase Inhibition by Quinolone Antibacterials

Advances in Pharmacology, 1994, Vol.29, p.285-304

Shen, Linus L.

1994

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Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents

Bioorganic & medicinal chemistry letters, 1998-08, Vol.8 (15), p.1953-1958

1998

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Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)

Journal of medicinal chemistry, 1987-12, Vol.30 (12), p.2283-2286

1987

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The 2-pyridone antibacterial agents: 8-position modifications

Current pharmaceutical design, 1999-07, Vol.5 (7), p.515-543

1999

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Kinetics of conformation change of sperm-whale myoglobin. III. Folding and unfolding of apomyoglobin and the suggested overall mechanism

Biochemistry (Easton), 1972-05, Vol.11 (10), p.1845-1849

1972

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The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors

In Vitro Antibacterial Potency and Spectrum of ABT-492, a New Fluoroquinolone

DNA Sequence Specificity for Topoisomerase II Poisoning by the Quinoxaline Anticancer Drugs XK469 and CQS

Novel Antibacterial Class

Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNA

Synthesis and Antimicrobial Activity of 4H-4-Oxoquinolizine Derivatives: Consequences of Structural Modification at the C-8 Position

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model

DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA

Quinobenoxazines: A Class of Novel Antitumor Quinolones and Potent Mammalian DNA Topoisomerase II Catalytic Inhibitors

Topoisomerase II Poisoning by ICRF-193

Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIα/β poison

Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents

Quinolones, 2-Pyridones and Resistant Type II DNA Topoisomerases

Mechanism of differential activities of ofloxacin enantiomers

ABT‐279 is a potent and selective inhibitor of DPPIV

Mass-length ratio of fibrin fibers from gel permeation and light scattering

Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2-trans-phenylcyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Mechanism of Inhibition of DNA Gyrase by Analogues of Nalidixic Acid: The Target of the Drugs is DNA

Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4,4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid

Molecular Mechanisms of DNA Gyrase Inhibition by Quinolone Antibacterials

Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents

Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)

The 2-pyridone antibacterial agents: 8-position modifications

Kinetics of conformation change of sperm-whale myoglobin. III. Folding and unfolding of apomyoglobin and the suggested overall mechanism

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