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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

PloS one, 2020-07, Vol.15 (7), p.e0234103-e0234103

2020

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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

Molecular cancer therapeutics, 2009-07, Vol.8 (7), p.1725-1738

2009

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Optimization of Imidazo[4,5‑b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8721-8734

2012

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Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10045-10065

2013

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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling

PloS one, 2012-01, Vol.7 (1), p.e28568

2012

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Facile Generation of a Library of 5-Aryl-2-arylsulfonyl-1,3-thiazoles

Synlett, 2006-02, Vol.2006 (3), p.0460-0462

2006

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Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors

Bioorganic & medicinal chemistry, 2011-11, Vol.19 (22), p.6949-6965

2011

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Conformation Analyses, Dynamic Behavior and Amide Bond Distortions of Medium-sized Heterocycles. 1. Partially and Fully Reduced 1-Benzazepines

Journal of organic chemistry, 2005-03, Vol.70 (5), p.1545-1551

2005

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Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography

Bioorganic & medicinal chemistry, 2012-11, Vol.20 (22), p.6630-6639

2012

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The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1017-1022

2007

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Conformation Analyses, Dynamic Behavior, and Amide Bond Distortions of Medium-sized Heterocycles. 2. Partially and Fully Reduced 1-Benzazocines, Benzazonines, and Benzazecines

Journal of organic chemistry, 2005-03, Vol.70 (5), p.1552-1557

2005

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Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single‐Molecule Spectroscopy

Angewandte Chemie International Edition, 2017-09, Vol.56 (38), p.11409-11414

2017

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Fadraciclib

PloS one, 2020-07, Vol.15 (7), p.e0234103

2020

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Dynamic Equilibrium of the AuroraA Kinase Activation Loop Revealed by Single-Molecule Spectroscopy

Angewandte Chemie International Edition, 2017-09, Vol.56 (38), p.11409

International ed. in English, 2017

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Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10045-10065

2013

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Dynamic Equilibrium of the AuroraA Kinase Activation Loop Revealed by Single-Molecule Spectroscopy

Angewandte Chemie, 2017-09, Vol.129 (38), p.11567

2017

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Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single‐Molecule Spectroscopy

Angewandte Chemie, 2017-09, Vol.129 (38), p.11567-11572

2017

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Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and proteinaligand crystallography

Bioorganic & medicinal chemistry, 2012-11, Vol.20 (22), p.6630-6639

2012

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Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (2), p.836-851

2011

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Abstract 3242: CCT271850, a novel, selective, highly potent and orally bioavailable Mps1 kinase inhibitor

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3242-3242

2013

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Synthesis of resorcinylic macrocycles related to radicicol via ring-closing metathesis

Tetrahedron letters, 2006-03, Vol.47 (13), p.2241-2243

2006

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Preparation of 5-Hydroxy-2-iodopyridine: A Refutation of Earlier Reports

Journal of organic chemistry, 1997-05, Vol.62 (9), p.3008-3009

1997

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Synthesis of SB-214857 using Copper Catalysed Amination of Arylbromides with l-Aspartic Acid

Synlett, 2001, Vol.2001 (9), p.1423-1427

2001

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Abstract 1817: Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.1817-1817

2012

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Development of synthetic routes to macrocyclic compounds based on the HSP90 inhibitor radicicol

Tetrahedron letters, 2006-03, Vol.47 (13), p.2237-2240

2006

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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

Optimization of Imidazo[4,5‑b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling

Facile Generation of a Library of 5-Aryl-2-arylsulfonyl-1,3-thiazoles

Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors

Conformation Analyses, Dynamic Behavior and Amide Bond Distortions of Medium-sized Heterocycles. 1. Partially and Fully Reduced 1-Benzazepines

Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography

The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium

Conformation Analyses, Dynamic Behavior, and Amide Bond Distortions of Medium-sized Heterocycles. 2. Partially and Fully Reduced 1-Benzazocines, Benzazonines, and Benzazecines

Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single‐Molecule Spectroscopy

Fadraciclib

Dynamic Equilibrium of the AuroraA Kinase Activation Loop Revealed by Single-Molecule Spectroscopy

Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Dynamic Equilibrium of the AuroraA Kinase Activation Loop Revealed by Single-Molecule Spectroscopy

Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single‐Molecule Spectroscopy

Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and proteinaligand crystallography

Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements

Abstract 3242: CCT271850, a novel, selective, highly potent and orally bioavailable Mps1 kinase inhibitor

Synthesis of resorcinylic macrocycles related to radicicol via ring-closing metathesis

Preparation of 5-Hydroxy-2-iodopyridine: A Refutation of Earlier Reports

Synthesis of SB-214857 using Copper Catalysed Amination of Arylbromides with l-Aspartic Acid

Abstract 1817: Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor

Development of synthetic routes to macrocyclic compounds based on the HSP90 inhibitor radicicol

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