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Learning versus confirming in clinical drug development

Clinical pharmacology and therapeutics, 1997-03, Vol.61 (3), p.275-291

Sheiner, Lewis B.

1997

Volltextzugriff (PDF)

Pharmacokinetic/pharmacodynamic modeling in drug development

Annual review of pharmacology and toxicology, 2000-01, Vol.40 (1), p.67-95

2000

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Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check

Journal of pharmacokinetics and pharmacodynamics, 2001-04, Vol.28 (2), p.171-192

2001

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Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer

Journal of clinical oncology, 1998-01, Vol.16 (1), p.187-196

1998

Volltextzugriff (PDF)

The importance of modeling interoccasion variability in population pharmacokinetic analyses

Journal of pharmacokinetics and biopharmaceutics, 1993-12, Vol.21 (6), p.735-750

1993

Volltextzugriff (PDF)

Intention-to-treat analysis and the goals of clinical trials

Clinical pharmacology and therapeutics, 1995-01, Vol.57 (1), p.6-15

1995

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A new approach to the analysis of analgesic drug trials, illustrated with bromfenac data

Clinical pharmacology and therapeutics, 1994-09, Vol.56 (3), p.309-322

Sheiner, Lewis B

1994

Volltextzugriff (PDF)

Quantitative characterization of therapeutic index: Application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships

Clinical pharmacology and therapeutics, 1999-06, Vol.65 (6), p.672-684

1999

Volltextzugriff (PDF)

Characterizing patterns of drug-taking behavior with a multiple drug regimen in an AIDS clinical trial

AIDS (London), 1998-12, Vol.12 (17), p.2295-2303

1998

Volltextzugriff (PDF)

Population Pharmacokinetics of Nevirapine, Zidovudine, and Didanosine in Human Immunodeficiency Virus-Infected Patients

Antimicrobial Agents and Chemotherapy, 1999-01, Vol.43 (1), p.121-128

1999

Volltextzugriff (PDF)

A Markov mixed effect regression model for drug compliance

Statistics in medicine, 1998-10, Vol.17 (20), p.2313-2333

1998

Volltextzugriff (PDF)

A population pharmacokinetic-pharmacodynamic analysis of repeated measures time-to-event pharmacodynamic responses : The antiemetic effect of ondansetron

Journal of pharmacokinetics and biopharmaceutics, 1999-12, Vol.27 (6), p.625-644

1999

Volltextzugriff (PDF)

The intellectual health of clinical drug evaluation

Clinical pharmacology and therapeutics, 1991-07, Vol.50 (1), p.4-9

Sheiner, Lewis B

1991

Volltextzugriff (PDF)

Population Pharmacokinetics and Pharmacodynamics of Efavirenz, Nelfinavir, and Indinavir: Adult AIDS Clinical Trial Group Study 398

Antimicrobial Agents and Chemotherapy, 2003-01, Vol.47 (1), p.130-137

2003

Volltextzugriff (PDF)

The need for mixed-effects modeling with population dichotomous data

Journal of pharmacokinetics and pharmacodynamics, 2001-08, Vol.28 (4), p.389-412

2001

Volltextzugriff (PDF)

Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy

Antimicrobial Agents and Chemotherapy, 1997-11, Vol.41 (11), p.2433-2438

1997

Volltextzugriff (PDF)

Pharmacodynamic model of tolerance: application to nicotine

The Journal of pharmacology and experimental therapeutics, 1988-01, Vol.244 (1), p.231

1988

Volltextzugriff (PDF)

A simulation study comparing designs for dose ranging

Statistics in medicine, 1991-03, Vol.10 (3), p.303-321

1991

Volltextzugriff (PDF)

Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects

Clinical pharmacology and therapeutics, 1993-01, Vol.53 (1), p.6-14

1993

Volltextzugriff (PDF)

Pharmacokinetics of saquinavir, zidovudine, and zalcitabine in combination therapy

Antimicrobial Agents and Chemotherapy, 1997-11, Vol.41 (11), p.2428-2432

1997

Volltextzugriff (PDF)

Comparison of twitch depression of the adductor pollicis and the respiratory muscles : pharmacodynamic modeling without plasma concentrations

Anesthesiology (Philadelphia), 1994-02, Vol.80 (2), p.310-319

1994

Volltextzugriff (PDF)

A pharmacodynamic model of erythropoietin therapy for uremic anemia

Clinical pharmacology and therapeutics, 1992-01, Vol.51 (1), p.76-89

1992

Volltextzugriff (PDF)

Selecting reliable pharmacokinetic data for explanatory analyses of clinical trials in the presence of possible noncompliance

Journal of pharmacokinetics and pharmacodynamics, 2001-08, Vol.28 (4), p.343-362

2001

Volltextzugriff (PDF)

Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide

American journal of physiology: endocrinology and metabolism, 1996-10, Vol.271 (4), p.E775-E787

1996

Volltextzugriff (PDF)

Study designs for dose-ranging

Clinical pharmacology and therapeutics, 1989-07, Vol.46 (1), p.63-77

1989

Volltextzugriff (PDF)

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Learning versus confirming in clinical drug development

Pharmacokinetic/pharmacodynamic modeling in drug development

Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check

Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer

The importance of modeling interoccasion variability in population pharmacokinetic analyses

Intention-to-treat analysis and the goals of clinical trials

A new approach to the analysis of analgesic drug trials, illustrated with bromfenac data

Quantitative characterization of therapeutic index: Application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships

Characterizing patterns of drug-taking behavior with a multiple drug regimen in an AIDS clinical trial

Population Pharmacokinetics of Nevirapine, Zidovudine, and Didanosine in Human Immunodeficiency Virus-Infected Patients

A Markov mixed effect regression model for drug compliance

A population pharmacokinetic-pharmacodynamic analysis of repeated measures time-to-event pharmacodynamic responses : The antiemetic effect of ondansetron

The intellectual health of clinical drug evaluation

Population Pharmacokinetics and Pharmacodynamics of Efavirenz, Nelfinavir, and Indinavir: Adult AIDS Clinical Trial Group Study 398

The need for mixed-effects modeling with population dichotomous data

Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy

Pharmacodynamic model of tolerance: application to nicotine

A simulation study comparing designs for dose ranging

Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects

Pharmacokinetics of saquinavir, zidovudine, and zalcitabine in combination therapy

Comparison of twitch depression of the adductor pollicis and the respiratory muscles : pharmacodynamic modeling without plasma concentrations

A pharmacodynamic model of erythropoietin therapy for uremic anemia

Selecting reliable pharmacokinetic data for explanatory analyses of clinical trials in the presence of possible noncompliance

Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide

Study designs for dose-ranging

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