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Molecular understanding of hyperglycemia's adverse effects for diabetic complications

JAMA : the journal of the American Medical Association, 2002-11, Vol.288 (20), p.2579

2002

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Inhibition of PKC β by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes- induced retinal hemodynamic abnormalities in patients

Investigative ophthalmology & visual science, 2006, Vol.47 (1), p.86-92

2006

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Primary Whole-gland Ablation for the Treatment of Clinically Localized Prostate Cancer: A Focal Therapy Society Best Practice Statement

European urology, 2023-12, Vol.84 (6), p.547-560

2023

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Oral protein kinase c β inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the Protein Kinase C β Inhibitor-Diabetic Retinopathy Study and the Protein Kinase C β Inhibitor-Diabetic Retinopathy Study 2

Retina (Philadelphia, Pa.), 2011-11, Vol.31 (10), p.2084-2094

2011

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The effect of the oral PKC β inhibitor ruboxistaurin on vision loss in two phase 3 studies

Investigative ophthalmology & visual science, 2013-03, Vol.54 (3), p.1750-1757

2013

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Community-Based Service Providers’ Experiences With Activities for Persons With Dementia

International journal of aging & human development, 2021-10, Vol.93 (3), p.881-903

2021

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Effect of Ruboxistaurin on Visual Loss in Patients with Diabetic Retinopathy

Ophthalmology (Rochester, Minn.), 2006-12, Vol.113 (12), p.2221-2230

2006

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Ruboxistaurin: PKC-β inhibition for complications of diabetes

Expert opinion on pharmacotherapy, 2009-12, Vol.10 (17), p.2913-2925

2009

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Alcohol Attentional Bias Is Associated With Autonomic Indices of Stress-Primed Alcohol Cue-Reactivity in Alcohol-Dependent Patients

Experimental and clinical psychopharmacology, 2012-06, Vol.20 (3), p.225-235

2012

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Effect of Ruboxistaurin on the Visual Acuity Decline Associated with Long-standing Diabetic Macular Edema

Investigative ophthalmology & visual science, 2009, Vol.50 (1), p.1-4

2009

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Estimated glomerular filtration rate progression in UK primary care patients with type 2 diabetes and diabetic kidney disease: a retrospective cohort study

International journal of clinical practice (Esher), 2015-08, Vol.69 (8), p.871-882

2015

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Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus

Development (Cambridge), 2005-12, Vol.132 (23), p.5329-5339

2005

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The role of protein kinase C in the development of the complications of diabetes

Vitamins and Hormones, 2000, Vol.60, p.149-193

2000

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Effect of ruboxistaurin (RBX) On visual acuity decline over a 6-year period with cessation and reinstitution of therapy: results of an open-label extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2)

Retina (Philadelphia, Pa.), 2011-06, Vol.31 (6), p.1053

2011

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Sustained moderate visual loss as a predictive end point for visual loss in non-proliferative diabetic retinopathy

Eye (London), 2009-01, Vol.23 (1), p.209-214

2009

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Ruboxistaurin: Review of Safety and Efficacy in the Treatment of Diabetic Retinopathy

Clinical Medicine Insights: Therapeutics, 2010-01, Vol.2010 (2), p.625

2010

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End-of-life Care in Children With Advanced Heart Disease

AAP grand rounds, 2012-12, Vol.28 (6), p.69-69

2012

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Abstract 476: A human scFv as a tool to understand the biogenesis of a subset of oncogenic microRNAs

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.476-476

2018

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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Anti-Ferroportin Antibody in Patients with Anemia Due to Chronic Renal Failure

Blood, 2016-12, Vol.128 (22), p.1280-1280

2016

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EFFECT OF RUBOXISTAURIN (RBX) ON VISUAL ACUITY DECLINE OVER A 6-YEAR PERIOD WITH CESSATION AND REINSTITUTION OF THERAPY: Results of an Open-Label Extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2)

Retina (Philadelphia, Pa.), 2011-06, Vol.31 (6), p.1053-1059

2011

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Splenomegaly in dogs: predictors of neoplasia and survival after splenectomy

Journal of veterinary internal medicine, 1989-07, Vol.3 (3), p.160-166

1989

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MDL 29311, a phenolic antioxidant, interferes with the interaction of apoC with VLDL: a possible explanation for its triglyceride-lowering effect

Journal of lipid research, 1995-12, Vol.36 (12), p.2609-2621

Sheetz, M.J.

1995

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Effects of phosphoprotein moieties on the remineralization of human root caries

Caries research, 1991, Vol.25 (3), p.166-173

1991

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Characterization of a glucagon receptor-linked protease from canine hepatic plasma membranes. Partial purification, kinetic analysis, and determination of sites for hormone processing

The Journal of biological chemistry, 1988-12, Vol.263 (35), p.19210-19217

1988

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Receptor-linked proteolysis of membrane-bound glucagon yields a membrane-associated hormone fragment

The Journal of biological chemistry, 1988-06, Vol.263 (17), p.8509-8514

1988

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Molecular understanding of hyperglycemia's adverse effects for diabetic complications

Inhibition of PKC β by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes- induced retinal hemodynamic abnormalities in patients

Primary Whole-gland Ablation for the Treatment of Clinically Localized Prostate Cancer: A Focal Therapy Society Best Practice Statement

Oral protein kinase c β inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the Protein Kinase C β Inhibitor-Diabetic Retinopathy Study and the Protein Kinase C β Inhibitor-Diabetic Retinopathy Study 2

The effect of the oral PKC β inhibitor ruboxistaurin on vision loss in two phase 3 studies

Community-Based Service Providers’ Experiences With Activities for Persons With Dementia

Effect of Ruboxistaurin on Visual Loss in Patients with Diabetic Retinopathy

Ruboxistaurin: PKC-β inhibition for complications of diabetes

Alcohol Attentional Bias Is Associated With Autonomic Indices of Stress-Primed Alcohol Cue-Reactivity in Alcohol-Dependent Patients

Effect of Ruboxistaurin on the Visual Acuity Decline Associated with Long-standing Diabetic Macular Edema

Estimated glomerular filtration rate progression in UK primary care patients with type 2 diabetes and diabetic kidney disease: a retrospective cohort study

Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus

The role of protein kinase C in the development of the complications of diabetes

Effect of ruboxistaurin (RBX) On visual acuity decline over a 6-year period with cessation and reinstitution of therapy: results of an open-label extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2)

Sustained moderate visual loss as a predictive end point for visual loss in non-proliferative diabetic retinopathy

Ruboxistaurin: Review of Safety and Efficacy in the Treatment of Diabetic Retinopathy

End-of-life Care in Children With Advanced Heart Disease

Abstract 476: A human scFv as a tool to understand the biogenesis of a subset of oncogenic microRNAs

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Anti-Ferroportin Antibody in Patients with Anemia Due to Chronic Renal Failure

EFFECT OF RUBOXISTAURIN (RBX) ON VISUAL ACUITY DECLINE OVER A 6-YEAR PERIOD WITH CESSATION AND REINSTITUTION OF THERAPY: Results of an Open-Label Extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2)

Splenomegaly in dogs: predictors of neoplasia and survival after splenectomy

MDL 29311, a phenolic antioxidant, interferes with the interaction of apoC with VLDL: a possible explanation for its triglyceride-lowering effect

Effects of phosphoprotein moieties on the remineralization of human root caries

Characterization of a glucagon receptor-linked protease from canine hepatic plasma membranes. Partial purification, kinetic analysis, and determination of sites for hormone processing

Receptor-linked proteolysis of membrane-bound glucagon yields a membrane-associated hormone fragment

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