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Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-β/ALK5 inhibitor

Scientific reports, 2022-09, Vol.12 (1), p.16104-16104, Article 16104

2022

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EW‐7203, a novel small molecule inhibitor of transforming growth factor‐β (TGF‐β) type I receptor/activin receptor‐like kinase‐5, blocks TGF‐β1‐mediated epithelial‐to‐mesenchymal transition in mammary epithelial cells

Cancer science, 2011-10, Vol.102 (10), p.1889-1896

2011

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The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles

Toxicology letters, 2009-09, Vol.189 (3), p.177-183

2009

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TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling

Scientific reports, 2015-11, Vol.5 (1), p.16492-16492, Article 16492

2015

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EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis

Molecular cancer therapeutics, 2014-07, Vol.13 (7), p.1704-1716

2014

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TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition

Cellular physiology and biochemistry, 2016-01, Vol.38 (2), p.571-588

2016

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Comprehensive analysis of differential gene expression profiles on carbon tetrachloride-induced rat liver injury and regeneration

Toxicology and applied pharmacology, 2005-08, Vol.206 (1), p.27-42

2005

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Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy

Biomolecules & Therapeutics, 2013, 21(5), , pp.323-331

2013

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Novel oral transforming growth factor‐β signaling inhibitor EW‐7197 eradicates CML‐initiating cells

Cancer science, 2016-02, Vol.107 (2), p.140-148

2016

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EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung

European journal of cancer (1990), 2011-11, Vol.47 (17), p.2642-2653

2011

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Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5- a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (20), p.6049-6053

2011

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Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors

European journal of medicinal chemistry, 2012-11, Vol.57, p.74-84

2012

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Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic & medicinal chemistry, 2011-04, Vol.19 (8), p.2633-2640

2011

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Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

European journal of medicinal chemistry, 2011-09, Vol.46 (9), p.3917-3925

2011

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Synthesis and biological evaluation of 4(5)-(6-methylpyridin-2-yl)imidazoles and -pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (12), p.4459-4467

2010

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Quantitative assessment of estrogenic activity in the water environment of Korea by the E-SCREEN assay

The Science of the total environment, 2000-12, Vol.263 (1), p.161-169

2000

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My Opinion on the Report of ILSI Korea on ‘System of Function Claims for the General Food’

Food Supplements and Biomaterials for Health, 2021-12, Vol.1 (4)

Sheen, Yhun Yhong

2021

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EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling

Cellular and molecular life sciences : CMLS, 2015-05, Vol.72 (10), p.2023-2039

2015

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Melphalan Modulates the Expression of E7-Specific Biomarkers in E7-Tg Mice

Anticancer research, 2010-07, Vol.30 (7), p.2773-2783

2010

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Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer

Biomolecules & therapeutics, 2012-05, Vol.20 (3), p.313-319

2012

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Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer

Biomolecules & Therapeutics, 2012, 20(3), , pp.313-319

2012

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Discovery of N‑((4-([1,2,4]Triazolo[1,5‑a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)‑1H‑imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF‑β Type I Receptor Kinase as Cancer Immunotherapeutic/Antifibrotic Agent

Journal of medicinal chemistry, 2014-05, Vol.57 (10), p.4213-4238

2014

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Identification of EBP50 as a Specific Biomarker for Carcinogens Via the Analysis of Mouse Lymphoma Cellular Proteome

Molecules and Cells, 2012, 33(3), , pp.309-316

2012

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Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer

Biomolecules & therapeutics, 2012-01, Vol.20 (1), p.81-88

2012

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Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer

Biomolecules & Therapeutics, 2012, 20(1), , pp.81-88

2012

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Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-β/ALK5 inhibitor

EW‐7203, a novel small molecule inhibitor of transforming growth factor‐β (TGF‐β) type I receptor/activin receptor‐like kinase‐5, blocks TGF‐β1‐mediated epithelial‐to‐mesenchymal transition in mammary epithelial cells

The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles

TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling

EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis

TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition

Comprehensive analysis of differential gene expression profiles on carbon tetrachloride-induced rat liver injury and regeneration

Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy

Novel oral transforming growth factor‐β signaling inhibitor EW‐7197 eradicates CML‐initiating cells

EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung

Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5- a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Synthesis and biological evaluation of 4(5)-(6-methylpyridin-2-yl)imidazoles and -pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Quantitative assessment of estrogenic activity in the water environment of Korea by the E-SCREEN assay

My Opinion on the Report of ILSI Korea on ‘System of Function Claims for the General Food’

EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling

Melphalan Modulates the Expression of E7-Specific Biomarkers in E7-Tg Mice

Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer

Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer

Discovery of N‑((4-([1,2,4]Triazolo[1,5‑a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)‑1H‑imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF‑β Type I Receptor Kinase as Cancer Immunotherapeutic/Antifibrotic Agent

Identification of EBP50 as a Specific Biomarker for Carcinogens Via the Analysis of Mouse Lymphoma Cellular Proteome

Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer

Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer

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