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Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations

PloS one, 2016-07, Vol.11 (7), p.e0158352-e0158352

2016

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Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

Pharmaceutics, 2021-12, Vol.14 (1), p.71

2021

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Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis

Pharmaceutics, 2021-09, Vol.13 (10), p.1557

2021

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Prolonging the Action of Protein and Peptide Drugs by a Novel Approach of Reversible Polyethylene Glycol Modification

The Journal of biological chemistry, 2004-09, Vol.279 (37), p.38118-38124

2004

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Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome

Diabetes (New York, N.Y.), 2013-04, Vol.62 (4), p.1121-1130

2013

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Insulin-like effects of vanadium: basic and clinical implications

Journal of inorganic biochemistry, 2000-05, Vol.80 (1), p.21-25

2000

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Reversible PEGylation of peptide YY3-36 prolongs its inhibition of food intake in mice

FEBS letters, 2005-04, Vol.579 (11), p.2439-2444

2005

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Converting bleomycin into a prodrug that undergoes spontaneous reactivation under physiological conditions

Toxicology and applied pharmacology, 2019-12, Vol.384, p.114782, Article 114782

2019

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Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes

Biochemistry (Easton), 1992-09, Vol.31 (34), p.8059-8063

1992

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Insulinlike effects of zinc ion in vitro and in vivo. Preferential effects on desensitized adipocytes and induction of normoglycemia in streptozocin-induced rats

Diabetes (New York, N.Y.), 1992-08, Vol.41 (8), p.982

1992

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A Novel Approach for a Water-Soluble Long-Acting Insulin Prodrug: Design, Preparation, and Analysis of [(2-Sulfo)-9-fluorenylmethoxycarbonyl]3-insulin

Journal of medicinal chemistry, 2000-06, Vol.43 (13), p.2530-2537

2000

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Evidence for the Distinct Vanadyl(+4)-Dependent Activating System for Manifesting Insulin-Like Effects

Biochemistry (Easton), 1996-06, Vol.35 (25), p.8314-8318

1996

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Organic Vanadium Chelators Potentiate Vanadium-Evoked Glucose Metabolism In Vitro and In Vivo: Establishing Criteria for Optimal Chelators

Molecular pharmacology, 2000-10, Vol.58 (4), p.738-746

2000

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Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes

Coordination chemistry reviews, 2003-02, Vol.237 (1), p.3-11

2003

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Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome: Lessons From the Fructose-Fed Rat Model

Diabetes (New York, N.Y.), 2013-04, Vol.62 (4), p.1121-1130

2013

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Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins

The Journal of biological chemistry, 2012-12, Vol.287 (53), p.44676-44683

2012

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Combined Local Blood–Brain Barrier Opening and Systemic Methotrexate for the Treatment of Brain Tumors

Journal of cerebral blood flow and metabolism, 2015-06, Vol.35 (6), p.967-976

2015

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Permolybdate and Pertungstate-Potent Stimulators of Insulin Effects in Rat Adipocytes: Mechanism of Action

Biochemistry (Easton), 1995-05, Vol.34 (18), p.6218-6225

1995

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Turning Low-Molecular-Weight Drugs into Prolonged Acting Prodrugs by Reversible Pegylation: A Study with Gentamicin

Journal of medicinal chemistry, 2008-07, Vol.51 (14), p.4300-4305

2008

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Newly Designed Modifier Prolongs the Action of Short-Lived Peptides and Proteins by Allowing Their Binding to Serum Albumin

Bioconjugate chemistry, 2012-08, Vol.23 (8), p.1577-1586

2012

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Insulin-like effects of vanadium: Mechanisms of action, clinical and basic implications

International journal of peptide research and therapeutics, 1998-10, Vol.5 (5-6), p.319-322

Shechter, Yoram

1998

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Prolonging the Half-Life of Human Interferon-α2 in Circulation: Design, Preparation, and Analysis of (2-Sulfo-9-Fluorenylmethoxycarbonyl)7-Interferon-α2

Proceedings of the National Academy of Sciences - PNAS, 2001-01, Vol.98 (3), p.1212-1217

2001

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A cytosolic protein tyrosine kinase in rat adipocytes

FEBS letters, 1992-03, Vol.300 (1), p.93-96

1992

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Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes

Diabetes (New York, N.Y.), 1990-01, Vol.39 (1), p.1

Shechter, Y

1990

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Reversible PEGylation: A Novel Technology To Release Native Interferon α2 over a Prolonged Time Period

Journal of medicinal chemistry, 2004-09, Vol.47 (20), p.4897-4904

2004

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Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations

Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis

Prolonging the Action of Protein and Peptide Drugs by a Novel Approach of Reversible Polyethylene Glycol Modification

Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome

Insulin-like effects of vanadium: basic and clinical implications

Reversible PEGylation of peptide YY3-36 prolongs its inhibition of food intake in mice

Converting bleomycin into a prodrug that undergoes spontaneous reactivation under physiological conditions

Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes

Insulinlike effects of zinc ion in vitro and in vivo. Preferential effects on desensitized adipocytes and induction of normoglycemia in streptozocin-induced rats

A Novel Approach for a Water-Soluble Long-Acting Insulin Prodrug: Design, Preparation, and Analysis of [(2-Sulfo)-9-fluorenylmethoxycarbonyl]3-insulin

Evidence for the Distinct Vanadyl(+4)-Dependent Activating System for Manifesting Insulin-Like Effects

Organic Vanadium Chelators Potentiate Vanadium-Evoked Glucose Metabolism In Vitro and In Vivo: Establishing Criteria for Optimal Chelators

Historic perspective and recent developments on the insulin-like actions of vanadium; toward developing vanadium-based drugs for diabetes

Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome: Lessons From the Fructose-Fed Rat Model

Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins

Combined Local Blood–Brain Barrier Opening and Systemic Methotrexate for the Treatment of Brain Tumors

Permolybdate and Pertungstate-Potent Stimulators of Insulin Effects in Rat Adipocytes: Mechanism of Action

Turning Low-Molecular-Weight Drugs into Prolonged Acting Prodrugs by Reversible Pegylation: A Study with Gentamicin

Newly Designed Modifier Prolongs the Action of Short-Lived Peptides and Proteins by Allowing Their Binding to Serum Albumin

Insulin-like effects of vanadium: Mechanisms of action, clinical and basic implications

Prolonging the Half-Life of Human Interferon-α2 in Circulation: Design, Preparation, and Analysis of (2-Sulfo-9-Fluorenylmethoxycarbonyl)7-Interferon-α2

A cytosolic protein tyrosine kinase in rat adipocytes

Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes

Reversible PEGylation: A Novel Technology To Release Native Interferon α2 over a Prolonged Time Period

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