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Diphosphoinositol Polyphosphates: Metabolic Messengers?

Molecular pharmacology, 2009-08, Vol.76 (2), p.236-252

Shears, Stephen B

2009

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Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues

Molecules (Basel, Switzerland), 2020-10, Vol.25 (19), p.4515

2020

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Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

Nature communications, 2020-11, Vol.11 (1), p.6035-12, Article 6035

2020

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Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold

Advances in biological regulation, 2019-01, Vol.71, p.118-127

2019

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Towards pharmacological intervention in inositol pyrophosphate signalling

Biochemical Society transactions, 2016-02, Vol.44 (1), p.191-196

Shears, Stephen B

2016

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Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling

Journal of cellular physiology, 2018-03, Vol.233 (3), p.1897-1912

Shears, Stephen B.

2018

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IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family

Nature communications, 2014-06, Vol.5 (1), p.4178-4178, Article 4178

2014

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Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation

Angewandte Chemie (International ed.), 2014-09, Vol.53 (36), p.9508-9511

International ed. in English, 2014

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Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (10), p.1

2021

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Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse

PLoS genetics, 2018-03, Vol.14 (3), p.e1007297

2018

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Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

Cell reports (Cambridge), 2024-06, Vol.43 (6), p.114316-114316, Article 114316

2024

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Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress

Frontiers in physiology, 2019-03, Vol.10, p.222-222

2019

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Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels

PloS one, 2016-10, Vol.11 (10), p.e0165286

2016

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A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Nature communications, 2022-04, Vol.13 (1), p.2231-2231, Article 2231

2022

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A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

Cell reports (Cambridge), 2014-02, Vol.6 (4), p.646-656

2014

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Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP

Nature communications, 2014-08, Vol.5 (1), p.4628-4628, Article 4628

2014

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A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging

BMC research notes, 2018-12, Vol.11 (1), p.884-7, Article 884

2018

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Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Biomolecules (Basel, Switzerland), 2023-05, Vol.13 (6), p.885

2023

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Inositol pyrophosphates: Why so many phosphates?

Advances in biological regulation, 2015-01, Vol.57, p.203-216

Shears, Stephen B.

2015

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Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain

Biochemical journal, 2011-03, Vol.434 (3), p.415-426

2011

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Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

Biomolecules (Basel, Switzerland), 2023-01, Vol.13 (1), p.153

2023

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The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

Bioscience reports, 2013-02, Vol.33 (2), p.e00022

2013

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Structural and catalytic analyses of the InsP6 kinase activities of higher plant ITPKs

The FASEB journal, 2022-07, Vol.36 (7), p.e22380-n/a

2022

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Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response

PLoS pathogens, 2014-02, Vol.10 (2), p.e1003981

2014

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Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress

The Journal of biological chemistry, 2007-10, Vol.282 (42), p.30763-30775

2007

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Diphosphoinositol Polyphosphates: Metabolic Messengers?

Metabolism and Functions of Inositol Pyrophosphates: Insights Gained from the Application of Synthetic Analogues

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold

Towards pharmacological intervention in inositol pyrophosphate signalling

Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling

IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family

Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP

A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Inositol pyrophosphates: Why so many phosphates?

Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

Structural and catalytic analyses of the InsP6 kinase activities of higher plant ITPKs

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response

Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress

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