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2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia

Science (American Association for the Advancement of Science), 1990-02, Vol.247 (4942), p.571-574

1990

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Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

Journal of medicinal chemistry, 1992-06, Vol.35 (12), p.2274-2283

1992

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Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation

Diabetes (New York, N.Y.), 1998-04, Vol.47 (4), p.612-620

1998

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Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice

Schizophrenia research, 2000-05, Vol.42 (3), p.249-259

2000

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N-Substituted Adenosines as Novel Neuroprotective A1 Agonists with Diminished Hypotensive Effects

Journal of medicinal chemistry, 1999-09, Vol.42 (18), p.3463-3477

1999

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Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.901

1999

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Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells

Biochemical pharmacology, 2001-08, Vol.62 (4), p.431-438

2001

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The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance

Schizophrenia research, 2001-04, Vol.49 (1), p.193-201

2001

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Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice

European journal of pharmacology, 2000-08, Vol.402 (3), p.241-246

2000

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Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

European journal of pharmacology, 1998-09, Vol.356 (2), p.109-119

1998

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The triggering of spreading depression in the chick retina by nicotinic receptor agonists

European journal of pharmacology, 1997-10, Vol.337 (2), p.209-212

Sheardown, Malcolm J

1997

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Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4378-4384

1998

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1,2,5-Thiadiazole Analogues of Aceclidine as Potent m1 Muscarinic Agonists

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.379-392

1998

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Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex

Neuroreport, 1992-10, Vol.3 (10), p.916-918

Sheardown, Malcolm J

1992

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Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats

Neuroreport, 1998-10, Vol.9 (15), p.3481-3486

1998

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Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells22Abbreviations: 5-HT, 5-hydroxytryptamine; CHO, Chinese hamster ovary; PI, phosphoinositide; FLIPR, fluorimetric imaging plate reader; mCPP, m-chlorophenylpiperazine; DOI, 2,5-dimethoxy-4-iodoamphetamine hydrobromide, GPCR, G-protein-coupled receptor; and PCR, polymerase chain reaction

Biochemical pharmacology, 2001-08, Vol.62 (4), p.431-438

2001

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Chlormethiazole inhibits epileptiform activity by potentiating GABAA receptor function

Brain research, 2000-11, Vol.884 (1-2), p.31-34

2000

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Modulation of γ-aminobutyric acid responses in the rat optic nerve

European journal of pharmacology, 2000-08, Vol.401 (3), p.339-342

2000

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1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.02,6]heptanes as New Potent Muscarinic M1 Agonists: Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

Journal of medicinal chemistry, 1999-06, Vol.42 (11), p.1999-2006

1999

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Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic

The Journal of pharmacology and experimental therapeutics, 1997-05, Vol.281 (2), p.876

1997

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Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Journal of medicinal chemistry, 1997-02, Vol.40 (4), p.538-546

1997

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Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity

The Journal of pharmacology and experimental therapeutics, 1997-05, Vol.281 (2), p.884

1997

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Conformationally Constrained Analogues of the Muscarinic Agonist 3-(4-(Methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine. Synthesis, Receptor Affinity, and Antinociceptive Activity

Journal of medicinal chemistry, 1998-01, Vol.41 (1), p.109-116

1998

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Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2897-2902

1998

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Xanomeline, an M 1/M 4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice

Schizophrenia research, 2000-05, Vol.42 (3), p.249-259

2000

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2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation

Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice

N-Substituted Adenosines as Novel Neuroprotective A1 Agonists with Diminished Hypotensive Effects

Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells

The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance

Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

The triggering of spreading depression in the chick retina by nicotinic receptor agonists

Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity

1,2,5-Thiadiazole Analogues of Aceclidine as Potent m1 Muscarinic Agonists

Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex

Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats

Chlormethiazole inhibits epileptiform activity by potentiating GABAA receptor function

Modulation of γ-aminobutyric acid responses in the rat optic nerve

1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.02,6]heptanes as New Potent Muscarinic M1 Agonists: Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic

Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity

Conformationally Constrained Analogues of the Muscarinic Agonist 3-(4-(Methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine. Synthesis, Receptor Affinity, and Antinociceptive Activity

Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation

Xanomeline, an M 1/M 4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice

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