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A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Nature communications, 2019-01, Vol.10 (1), p.374-374, Article 374

2019

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Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (19), p.E2467-E2476

2015

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Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

Nature communications, 2019-01, Vol.10 (1), p.373-373, Article 373

2019

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DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

Cell reports (Cambridge), 2024-01, Vol.43 (1), p.113655-113655, Article 113655

2024

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A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability

PLoS genetics, 2013-10, Vol.9 (10), p.e1003899

2013

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Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae

G3 : genes - genomes - genetics, 2018-03, Vol.8 (3), p.1019-1029

2018

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DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA

PLoS genetics, 2015-03, Vol.11 (3), p.e1005110

2015

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Role of DNA Polymerases in Repeat-Mediated Genome Instability

Cell reports (Cambridge), 2012-11, Vol.2 (5), p.1088-1095

2012

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cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instability

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (1), p.157-162

2010

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Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy

DNA repair, 2017-08, Vol.56, p.16-25

2017

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A Common Cancer-Associated DNA Polymerase ε Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

Cancer research (Chicago, Ill.), 2014-04, Vol.74 (7), p.1895-1901

2014

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DNA polymerase δ proofreads errors made by DNA polymerase ε

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (11), p.6035-6041

2020

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Translesion synthesis DNA polymerases and control of genome stability

Frontiers in bioscience, 2006-09, Vol.11, p.2496

2006

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DNA polymerases at the eukaryotic fork—20 years later

Mutation research, 2010-03, Vol.685 (1), p.45-53

2010

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Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28

Genetics (Austin), 2021-06, Vol.218 (2)

2021

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Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae

Genetics (Austin), 2010-01, Vol.184 (1), p.27-42

2010

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DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures

Nucleic acids research, 2014-01, Vol.42 (1), p.290

2014

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Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

Nucleic acids research, 2017-02, Vol.45 (3), p.1200

2017

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The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Polζ/Rev1-dependent Translesion DNA Synthesis

The Journal of biological chemistry, 2011-09, Vol.286 (38), p.33557-33566

2011

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Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors

Clinical and translational gastroenterology, 2020-03, Vol.11 (3), p.e00149-e00149

2020

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Differential ATP Binding and Intrinsic ATP Hydrolysis by Amino-terminal Domains of the Yeast Mlh1 and Pms1 Proteins

The Journal of biological chemistry, 2002-02, Vol.277 (5), p.3673-3679

2002

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Abstract IA014: POLE mutations in endometrial cancer: Consequences and mechanisms

Clinical cancer research, 2021-02, Vol.27 (3_Supplement), p.IA014-IA014

Shcherbakova, Polina V.

2021

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A novel function of DNA polymerase ζ regulated by PCNA

The EMBO journal, 2006-09, Vol.25 (18), p.4316-4325

2006

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Unique Error Signature of the Four-subunit Yeast DNA Polymerase ϵ

The Journal of biological chemistry, 2003-10, Vol.278 (44), p.43770-43780

2003

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In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta

Genetics (Austin), 2001-09, Vol.159 (1), p.47-64

2001

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A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae

DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA

Role of DNA Polymerases in Repeat-Mediated Genome Instability

cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instability

Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy

A Common Cancer-Associated DNA Polymerase ε Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

DNA polymerase δ proofreads errors made by DNA polymerase ε

Translesion synthesis DNA polymerases and control of genome stability

DNA polymerases at the eukaryotic fork—20 years later

Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28

Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Polζ/Rev1-dependent Translesion DNA Synthesis

Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors

Differential ATP Binding and Intrinsic ATP Hydrolysis by Amino-terminal Domains of the Yeast Mlh1 and Pms1 Proteins

Abstract IA014: POLE mutations in endometrial cancer: Consequences and mechanisms

A novel function of DNA polymerase ζ regulated by PCNA

Unique Error Signature of the Four-subunit Yeast DNA Polymerase ϵ

In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta

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