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Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics

International journal of cancer, 2006-12, Vol.119 (12), p.2784-2794

2006

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Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.3086-3100

2007

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Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (10), p.3075-3080

2013

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (9), p.2743-2749

2013

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Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4298-4302

2008

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (21), p.6231-6236

2010

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1838-1843

2011

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Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4455-4458

2006

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Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors

Journal of medicinal chemistry, 2006-06, Vol.49 (13), p.3770-3773

2006

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Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.668-672

2007

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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4162-4176

2007

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Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1961-1965

2007

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A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth

Molecular cancer therapeutics, 2005-04, Vol.4 (4), p.562-568

2005

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Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.465-469

2002

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X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease

Bioorganic & medicinal chemistry, 2002-08, Vol.10 (8), p.2803-2806

2002

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Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2293-2298

2006

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Discovery of 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5944-5951

2007

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Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4308-4315

2007

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Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2590-2594

2006

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Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Journal of medicinal chemistry, 2002-04, Vol.45 (8), p.1697-1711

2002

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Novel cinnoline-based inhibitors of LRRK2 kinase activity

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.71-74

2013

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Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancer

Expert opinion on therapeutic patents, 2002-11, Vol.12 (11), p.1663-1702

2002

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Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (24), p.6226-6230

2006

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Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics

Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors

Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents

Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth

Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Discovery of 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Novel cinnoline-based inhibitors of LRRK2 kinase activity

Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancer

Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors

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