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Development of a physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies in rabbits

Journal of pharmacokinetics and pharmacodynamics, 2020-12, Vol.47 (6), p.597-612

2020

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Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Journal of pharmacokinetics and pharmacodynamics, 2012-02, Vol.39 (1), p.67-86

2012

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Pharmacokinetics of protein and peptide conjugates

Drug metabolism and pharmacokinetics, 2019-02, Vol.34 (1), p.42-54

2019

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Translational physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies

Journal of pharmacokinetics and pharmacodynamics, 2023-08

2023

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Evaluation of Quantitative Relationship Between Target Expression and Antibody-Drug Conjugate Exposure Inside Cancer Cells

Drug metabolism and disposition, 2020-05, Vol.48 (5), p.368-377

2020

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Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models

Advanced drug delivery reviews, 2021-03, Vol.170, p.214-237

2021

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Quantitative characterization of in vitro bystander effect of antibody-drug conjugates

Journal of pharmacokinetics and pharmacodynamics, 2016-12, Vol.43 (6), p.567-582

2016

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Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates Administered via Subcutaneous and Intratumoral Routes

Pharmaceutics, 2023-04, Vol.15 (4), p.1132

2023

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Effect of Size on Solid Tumor Disposition of Protein Therapeutics

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1136-1145

2019

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Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics

Journal of pharmacokinetics and pharmacodynamics, 2015-10, Vol.42 (5), p.553-571

Shah, Dhaval K.

2015

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Antibody pharmacokinetics in rat brain determined using microdialysis

mAbs, 2018-08, Vol.10 (6), p.843-853

2018

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A translational platform PBPK model for antibody disposition in the brain

Journal of pharmacokinetics and pharmacodynamics, 2019-08, Vol.46 (4), p.319-338

2019

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Pulmonary Pharmacokinetics of Antibody and Antibody Fragments Following Systemic and Local Administration in Mice

Pharmaceutics, 2024-09, Vol.16 (10), p.1259

2024

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Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies

mAbs, 2021-01, Vol.13 (1), p.1993769-1993769

2021

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Algorithmic multiscale analysis for the FcRn mediated regulation of antibody PK in human

Scientific reports, 2022-04, Vol.12 (1), p.6208-6208, Article 6208

2022

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Antibody-drug conjugates: an emerging modality for the treatment of cancer

Annals of the New York Academy of Sciences, 2014-08, Vol.1321 (1), p.41-54

2014

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Target‐Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy

CPT: pharmacometrics and systems pharmacology, 2019-03, Vol.8 (3), p.177-187

2019

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Two-pore physiologically based pharmacokinetic model validation using whole-body biodistribution of trastuzumab and different-size fragments in mice

Journal of pharmacokinetics and pharmacodynamics, 2021-10, Vol.48 (5), p.743-762

2021

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Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles

Advanced drug delivery reviews, 2023-03, Vol.194, p.114708, Article 114708

2023

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Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis

mAbs, 2021-01, Vol.13 (1), p.1874121

2021

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PK/TD modeling for prediction of the effects of 8C2, an anti-topotecan mAb, on topotecan-induced toxicity in mice

International journal of pharmaceutics, 2014-04, Vol.465 (1-2), p.228-238

2014

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Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

eLife, 2022-02, Vol.11

2022

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Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1)

The AAPS journal, 2016-07, Vol.18 (4), p.861-875

2016

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Inter-Antibody Variability in the Clinical Pharmacokinetics of Monoclonal Antibodies Characterized Using Population Physiologically Based Pharmacokinetic Modeling

Antibodies (Basel), 2024-07, Vol.13 (3), p.54

2024

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Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics

Drug metabolism and disposition, 2022-06, Vol.50 (6), p.867-878

2022

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Development of a physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies in rabbits

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Pharmacokinetics of protein and peptide conjugates

Translational physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies

Evaluation of Quantitative Relationship Between Target Expression and Antibody-Drug Conjugate Exposure Inside Cancer Cells

Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models

Quantitative characterization of in vitro bystander effect of antibody-drug conjugates

Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates Administered via Subcutaneous and Intratumoral Routes

Effect of Size on Solid Tumor Disposition of Protein Therapeutics

Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics

Antibody pharmacokinetics in rat brain determined using microdialysis

A translational platform PBPK model for antibody disposition in the brain

Pulmonary Pharmacokinetics of Antibody and Antibody Fragments Following Systemic and Local Administration in Mice

Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies

Algorithmic multiscale analysis for the FcRn mediated regulation of antibody PK in human

Antibody-drug conjugates: an emerging modality for the treatment of cancer

Target‐Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy

Two-pore physiologically based pharmacokinetic model validation using whole-body biodistribution of trastuzumab and different-size fragments in mice

Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles

Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis

PK/TD modeling for prediction of the effects of 8C2, an anti-topotecan mAb, on topotecan-induced toxicity in mice

Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1)

Inter-Antibody Variability in the Clinical Pharmacokinetics of Monoclonal Antibodies Characterized Using Population Physiologically Based Pharmacokinetic Modeling

Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics

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