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Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Nature (London), 2000-06, Vol.405 (6787), p.689-694

2000

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Presenilin 1 Is Linked with γ -Secretase Activity in the Detergent Solubilized State

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (11), p.6138-6143

2000

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An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey

Circulation (New York, N.Y.), 1995-06, Vol.91 (12), p.2961-2971

1995

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Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III

The Journal of biological chemistry, 1994-01, Vol.269 (2), p.1301-1305

1994

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L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor

Bioorganic & medicinal chemistry letters, 1998-04, Vol.8 (7), p.817-822

1998

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A kinetic model for the alpha-thrombin-catalyzed conversion of plasma levels of fibrinogen to fibrin in the presence of antithrombin III

The Journal of biological chemistry, 1991-07, Vol.266 (20), p.13003-13010

1991

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Outcome of hematopoietic stem cell transplant as salvage therapy for Hodgkin's lymphoma in adolescents and young adults at a single institution

Leukemia & lymphoma, 2010-04, Vol.51 (4), p.664-670

2010

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The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen

The Journal of biological chemistry, 1990-08, Vol.265 (23), p.13484-13489

1990

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Functional characterization of promoter elements involved in regulation of human B beta-fibrinogen expression. Evidence for binding of novel activator and repressor proteins

The Journal of biological chemistry, 1993-10, Vol.268 (30), p.22650-22655

1993

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Phosphorylation of Highly Purified Growth Hormone Receptors by a Growth Hormone Receptor-associated Tyrosine Kinase

The Journal of biological chemistry, 1989-11, Vol.264 (31), p.18654-18661

1989

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Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates

Biochemistry (Easton), 1994-01, Vol.33 (1), p.98-105

1994

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The Pro Domain of β-Secretase Does Not Confer Strict Zymogen-like Properties but Does Assist Proper Folding of the Protease Domain

The Journal of biological chemistry, 2001-03, Vol.276 (13), p.10366-10373

2001

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Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin

The Journal of biological chemistry, 1985-06, Vol.260 (11), p.7131-7136

1985

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Interactions of factor XIII with fibrin as substrate and cofactor

Biochemistry (Easton), 1992-01, Vol.31 (2), p.423-429

1992

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Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Journal of medicinal chemistry, 1998-11, Vol.41 (23), p.4466-4474

1998

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Inhibition of HIV-1 reverse transcriptase by pyridinone derivatives. Potency, binding characteristics, and effect of template sequence

The Journal of biological chemistry, 1993-01, Vol.268 (1), p.276-281

1993

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Sensitivity of HIV-1 Reverse Transcriptase and Its Mutants to Inhibition by Azidothymidine Triphosphate

Biochemistry (Easton), 1994-03, Vol.33 (8), p.2113-2120

1994

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Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans

The Journal of biological chemistry, 1999-12, Vol.274 (49), p.35046

1999

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Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin

The Journal of biological chemistry, 1983-08, Vol.258 (15), p.9276-9282

1983

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Purification of active herpes simplex virus-1 protease expressed in Escherichia coli

The Journal of biological chemistry, 1994-07, Vol.269 (29), p.18708-18711

1994

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Alterations in catalytic activity and virus maturation produced by mutation of the conserved histidine residues of herpes simplex virus type 1 protease

Journal of Virology, 1997-11, Vol.71 (11), p.8572-8581

1997

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Role of calcium ion in the generation of factor XIII activity

Biochemistry (Easton), 1991-06, Vol.30 (25), p.6175-6182

1991

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Characterization of the kinetic pathway for liberation of fibrinopeptides during assembly of fibrin

The Journal of biological chemistry, 1985-08, Vol.260 (18), p.10192-10199

1985

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Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

Biochemistry (Easton), 1986-09, Vol.25 (19), p.5595-5601

1986

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Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases

The Journal of biological chemistry, 1994-10, Vol.269 (42), p.26344-26348

1994

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Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Presenilin 1 Is Linked with γ -Secretase Activity in the Detergent Solubilized State

An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey

Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor

A kinetic model for the alpha-thrombin-catalyzed conversion of plasma levels of fibrinogen to fibrin in the presence of antithrombin III

Outcome of hematopoietic stem cell transplant as salvage therapy for Hodgkin's lymphoma in adolescents and young adults at a single institution

The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen

Functional characterization of promoter elements involved in regulation of human B beta-fibrinogen expression. Evidence for binding of novel activator and repressor proteins

Phosphorylation of Highly Purified Growth Hormone Receptors by a Growth Hormone Receptor-associated Tyrosine Kinase

Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates

The Pro Domain of β-Secretase Does Not Confer Strict Zymogen-like Properties but Does Assist Proper Folding of the Protease Domain

Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin

Interactions of factor XIII with fibrin as substrate and cofactor

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Inhibition of HIV-1 reverse transcriptase by pyridinone derivatives. Potency, binding characteristics, and effect of template sequence

Sensitivity of HIV-1 Reverse Transcriptase and Its Mutants to Inhibition by Azidothymidine Triphosphate

Characterization of plasmin-mediated activation of plasma procarboxypeptidase B. Modulation by glycosaminoglycans

Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin

Purification of active herpes simplex virus-1 protease expressed in Escherichia coli

Alterations in catalytic activity and virus maturation produced by mutation of the conserved histidine residues of herpes simplex virus type 1 protease

Role of calcium ion in the generation of factor XIII activity

Characterization of the kinetic pathway for liberation of fibrinopeptides during assembly of fibrin

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases

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