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High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (20), p.7266-7271

Seyedsayamdost, Mohammad R.

2014

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Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI‐MS‐Guided High‐Throughput Elicitor Screening

Angewandte Chemie International Edition, 2020-12, Vol.59 (51), p.23005-23009

International ed. in English, 2020

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Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

Nature chemistry, 2015-05, Vol.7 (5), p.431-437

2015

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Synergy and Target Promiscuity Drive Structural Divergence in Bacterial Alkylquinolone Biosynthesis

Cell chemical biology, 2017-12, Vol.24 (12), p.1437-1444.e3

2017

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Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered Using Bioactivity‐Coupled HiTES

Angewandte Chemie International Edition, 2019-04, Vol.58 (18), p.5973-5977

International ed. in English, 2019

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The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis

Nature chemistry, 2011-04, Vol.3 (4), p.331-335

2011

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Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens

Journal of the American Chemical Society, 2017-07, Vol.139 (27), p.9203-9212

2017

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Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis

Journal of the American Chemical Society, 2019-07, Vol.141 (27), p.10610-10615

2019

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Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif

Journal of the American Chemical Society, 2018-12, Vol.140 (50), p.17674-17684

2018

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A genetics-free method for high-throughput discovery of cryptic microbial metabolites

Nature chemical biology, 2019-02, Vol.15 (2), p.161-168

2019

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In Vitro Reconstitution of OxyC Activity Enables Total Chemoenzymatic Syntheses of Vancomycin Aglycone Variants

Angewandte Chemie International Edition, 2018-07, Vol.57 (27), p.8048-8052

International ed. in English, 2018

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MetEx, a Metabolomics Explorer Application for Natural Product Discovery

ACS chemical biology, 2021-12, Vol.16 (12), p.2825-2833

2021

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CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from Streptomyces canus

ACS chemical biology, 2020-04, Vol.15 (4), p.890-894

2020

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Interspecies modulation of bacterial development through iron competition and siderophore piracy

Molecular microbiology, 2012-11, Vol.86 (3), p.628-644

2012

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Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (6), p.1630-1635

2016

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Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition

Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (39), p.10420-10425

2017

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Total Synthesis and Stereochemical Assignment of Streptide

Journal of the American Chemical Society, 2019-10, Vol.141 (43), p.17361-17369

2019

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Catecholate siderophores protect bacteria from pyochelin toxicity

PloS one, 2012-10, Vol.7 (10), p.e46754

2012

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Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening

ACS chemical biology, 2023-08, Vol.18 (8), p.1854-1862

2023

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Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa

PLoS pathogens, 2020-09, Vol.16 (9), p.e1008867-e1008867

2020

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Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound

mBio, 2021-03, Vol.12 (2)

2021

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Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis

ACS chemical biology, 2016-08, Vol.11 (8), p.2124-2130

2016

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Toward a global picture of bacterial secondary metabolism

Journal of industrial microbiology & biotechnology, 2019-03, Vol.46 (3-4), p.301-311

Seyedsayamdost, Mohammad R.

2019

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Genomes and virulence factors of novel bacterial pathogens causing bleaching disease in the marine red alga Delisea pulchra

PloS one, 2011-12, Vol.6 (12), p.e27387-e27387

2011

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Structure and Biosynthesis of Amychelin, an Unusual Mixed-Ligand Siderophore from Amycolatopsis sp. AA4

Journal of the American Chemical Society, 2011-08, Vol.133 (30), p.11434-11437

2011

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High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI‐MS‐Guided High‐Throughput Elicitor Screening

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

Synergy and Target Promiscuity Drive Structural Divergence in Bacterial Alkylquinolone Biosynthesis

Cebulantin, a Cryptic Lanthipeptide Antibiotic Uncovered Using Bioactivity‐Coupled HiTES

The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis

Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens

Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis

Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif

A genetics-free method for high-throughput discovery of cryptic microbial metabolites

In Vitro Reconstitution of OxyC Activity Enables Total Chemoenzymatic Syntheses of Vancomycin Aglycone Variants

MetEx, a Metabolomics Explorer Application for Natural Product Discovery

CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from Streptomyces canus

Interspecies modulation of bacterial development through iron competition and siderophore piracy

Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink

Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition

Total Synthesis and Stereochemical Assignment of Streptide

Catecholate siderophores protect bacteria from pyochelin toxicity

Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening

Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa

Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound

Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis

Toward a global picture of bacterial secondary metabolism

Genomes and virulence factors of novel bacterial pathogens causing bleaching disease in the marine red alga Delisea pulchra

Structure and Biosynthesis of Amychelin, an Unusual Mixed-Ligand Siderophore from Amycolatopsis sp. AA4

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