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Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors

Molecules (Basel, Switzerland), 2014-10, Vol.19 (10), p.16543-16572

2014

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On the reactivity of nitrosoimidazoles with acids (the Cusmano–Ruccia reaction): a continuous source of new ring-into-ring interconversion

Tetrahedron letters, 2014-02, Vol.55 (8), p.1488-1490

2014

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P2X7 antagonists for CNS indications: recent patent disclosures

Pharmaceutical patent analyst, 2017-03, Vol.6 (2), p.61-76

2017

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Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling

European journal of medicinal chemistry, 2014-08, Vol.83, p.45-56

2014

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Allosteric modulators of human A2B adenosine receptor

Biochimica et biophysica acta, 2014-03, Vol.1840 (3), p.1194-1203

2014

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Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3340-3352

2016

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Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives

European journal of medicinal chemistry, 2013-11, Vol.69, p.331-337

2013

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Selective and Practical Oxidation of Sulfides to Diastereopure Sulfoxides: A Combined Experimental and Computational Investigation

Advanced synthesis & catalysis, 2013-01, Vol.355 (1), p.191-202

2013

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Synthesis and L-type calcium channel blocking activity of new chiral oxadiazolothiazinones

European journal of medicinal chemistry, 2015-03, Vol.92, p.481-489

2015

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Inhibition of MDR1 Activity in Vitro by a Novel Class of Diltiazem Analogues: Toward New Candidates

Journal of medicinal chemistry, 2009-01, Vol.52 (2), p.259-266

2009

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Nitrobutadienes from ß-nitrothiophenes: valuable building-blocks in the overall ring-opening / ring-closure protocol to homo- or hetero-cycles

ARKIVOC, 2006-01, Vol.2006 (7), p.169-185

2006

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ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin-3-one Inhibitors

ACS medicinal chemistry letters, 2013-08, Vol.4 (8), p.694-698

2013

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Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein

European journal of medicinal chemistry, 2011-09, Vol.46 (9), p.4506-4520

2011

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Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects

Organic & biomolecular chemistry, 2012-12, Vol.1 (45), p.8994-93

2012

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Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives

Journal of medicinal chemistry, 2011-08, Vol.54 (15), p.5597-5601

2011

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A new route to thiopyran S, S-dioxide derivatives via an overall ring-enlargement protocol from 3-nitrothiophene

Tetrahedron, 2009-01, Vol.65 (1), p.336-343

2009

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Ring-Opening/Ring-Closing Protocols from Nitrothiophenes: Six-Membered versus Unusual Eight-Membered Sulfur Heterocycles through Michael-Type Addition on Nitrobutadienes

Chemistry : a European journal, 2010-01, Vol.16 (4), p.1312-1318

2010

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ortho-Substituted (Aryl)(3-nitrobenzo[b]thiophen-2-yl)amines: Study of the Electrochemical Behavior

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2009-09, Vol.113 (38), p.10260-10263

2009

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Ca(2+) release-activated Ca(2+) channel inhibitors

Pharmaceutical patent analyst, 2014-03, Vol.3 (2), p.171-182

2014

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Derivatives of Benzimidazol‐2‐ylquinoline and Benzimidazol‐2‐ylisoquinoline as Selective A 1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility

ChemMedChem, 2011-10, Vol.6 (10), p.1909-1918

2011

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From β-nitrothiophenes to ring-fused nitrobenzenes : An overall ring-enlargement process via a facile, aromatization-driven, thermal 6π electrocyclization

Journal of organic chemistry, 2005-10, Vol.70 (22), p.8734-8738

2005

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Butadienic Building Blocks from 2-Nitrothiophene as Precursors of Nitrogen Heterocycles: Intriguing Dichotomic Behavior

Journal of organic chemistry, 2007-11, Vol.72 (24), p.9067-9073

2007

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Ca 2+ release-activated Ca 2+ Channel Inhibitors

Pharmaceutical patent analyst, 2014-03, Vol.3 (2), p.171-182

2014

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A new route to thiopyran 5,5-dioxide derivatives via an overall ring-enlargement protocol from 3-nitrothiophene

Tetrahedron, 2009, Vol.65 (1)

2009

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Derivatives of Benzimidazol-2-ylquinoline and Benzimidazol-2-ylisoquinoline as Selective A1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility

ChemMedChem, 2011-10, Vol.6 (10), p.1909-1918

2011

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Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors

On the reactivity of nitrosoimidazoles with acids (the Cusmano–Ruccia reaction): a continuous source of new ring-into-ring interconversion

P2X7 antagonists for CNS indications: recent patent disclosures

Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling

Allosteric modulators of human A2B adenosine receptor

Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism

Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives

Selective and Practical Oxidation of Sulfides to Diastereopure Sulfoxides: A Combined Experimental and Computational Investigation

Synthesis and L-type calcium channel blocking activity of new chiral oxadiazolothiazinones

Inhibition of MDR1 Activity in Vitro by a Novel Class of Diltiazem Analogues: Toward New Candidates

Nitrobutadienes from ß-nitrothiophenes: valuable building-blocks in the overall ring-opening / ring-closure protocol to homo- or hetero-cycles

ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin-3-one Inhibitors

Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein

Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects

Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives

A new route to thiopyran S, S-dioxide derivatives via an overall ring-enlargement protocol from 3-nitrothiophene

Ring-Opening/Ring-Closing Protocols from Nitrothiophenes: Six-Membered versus Unusual Eight-Membered Sulfur Heterocycles through Michael-Type Addition on Nitrobutadienes

ortho-Substituted (Aryl)(3-nitrobenzo[b]thiophen-2-yl)amines: Study of the Electrochemical Behavior

Ca(2+) release-activated Ca(2+) channel inhibitors

Derivatives of Benzimidazol‐2‐ylquinoline and Benzimidazol‐2‐ylisoquinoline as Selective A 1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility

From β-nitrothiophenes to ring-fused nitrobenzenes : An overall ring-enlargement process via a facile, aromatization-driven, thermal 6π electrocyclization

Butadienic Building Blocks from 2-Nitrothiophene as Precursors of Nitrogen Heterocycles: Intriguing Dichotomic Behavior

Ca 2+ release-activated Ca 2+ Channel Inhibitors

A new route to thiopyran 5,5-dioxide derivatives via an overall ring-enlargement protocol from 3-nitrothiophene

Derivatives of Benzimidazol-2-ylquinoline and Benzimidazol-2-ylisoquinoline as Selective A1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility

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