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CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

Journal of experimental & clinical cancer research, 2022-02, Vol.41 (1), p.49-17, Article 49

2022

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GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

Drug delivery, 2022-12, Vol.29 (1), p.1384-1397

2022

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Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

Biomedicine & pharmacotherapy, 2023-08, Vol.164, p.114976-114976, Article 114976

2023

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An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

Journal of hematology and oncology, 2020-04, Vol.13 (1), p.36-19, Article 36

2020

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An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials

International journal of molecular sciences, 2022-04, Vol.23 (9), p.4958

2022

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Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria

Human molecular genetics, 2018-11, Vol.27 (21), p.3688-3696

2018

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Artificial Inclusion Bodies for Clinical Development

Advanced science, 2020-02, Vol.7 (3), p.1902420-n/a

2020

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A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice

Biomedicine & pharmacotherapy, 2022-06, Vol.150, p.112940-112940, Article 112940

2022

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Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials

Pharmaceutics, 2022-01, Vol.14 (1), p.192

2022

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The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles

Pharmaceutics, 2022-11, Vol.14 (12), p.2644

2022

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T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

Pharmaceutics, 2023-02, Vol.15 (3), p.727

2023

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Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors

Acta pharmaceutica Sinica. B, 2022-05, Vol.12 (5), p.2578-2591

2022

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The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies

Pharmaceutics, 2022-03, Vol.14 (3), p.602

2022

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Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Pharmaceutics, 2020-10, Vol.12 (11), p.1004

2020

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Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4

Pharmaceutics, 2021-11, Vol.13 (11), p.1922

2021

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Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation

Pharmaceutics, 2023-11, Vol.15 (11), p.2632

2023

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Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4+ Cancers

Cancers, 2021-06, Vol.13 (12), p.2929

2021

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A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

Pharmaceutics, 2022-04, Vol.14 (4), p.887

2022

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In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics

Pharmaceutics, 2020-12, Vol.12 (12), p.1217

2020

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Nanostructured antimicrobial peptides: The last push towards clinics

Biotechnology advances, 2020-11, Vol.44, p.107603-13, Article 107603

2020

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Protein-Based Therapeutic Killing for Cancer Therapies

Trends in biotechnology (Regular ed.), 2018-03, Vol.36 (3), p.318-335

2018

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Endosomal escape for cell-targeted proteins. Going out after going in

Biotechnology advances, 2023-03, Vol.63, p.108103-108103, Article 108103

2023

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Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

Journal of controlled release, 2020-04, Vol.320, p.96-104

2020

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Protein scaffolds in human clinics

Biotechnology advances, 2022-12, Vol.61, p.108032, Article 108032

2022

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High-precision targeting and destruction of cancer-associated PDGFR-β+ stromal fibroblasts through self-assembling, protein-only nanoparticles

Acta biomaterialia, 2023-10, Vol.170, p.543-555

2023

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CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma

GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases

Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials

Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria

Artificial Inclusion Bodies for Clinical Development

A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice

Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials

The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles

T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors

The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4

Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation

Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4+ Cancers

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics

Nanostructured antimicrobial peptides: The last push towards clinics

Protein-Based Therapeutic Killing for Cancer Therapies

Endosomal escape for cell-targeted proteins. Going out after going in

Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

Protein scaffolds in human clinics

High-precision targeting and destruction of cancer-associated PDGFR-β+ stromal fibroblasts through self-assembling, protein-only nanoparticles

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